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Introduction: The prevalence of hepatitis C (HCV) is high among prisoners. If untreated, a substantial number of patients progress to cirrhosis, hepatocarcinoma, or liver failure. World Health Organization aims to reduce the incidence of infection by 90% by 2030. Objective: To describe the prevalence of anti-HCV and sociodemographic and clinical aspects, related to the presence of the antibody, in the population deprived of liberty. Methods: Cross-sectional and epidemiological survey, with exploratory, observational, quantitative-analytical components. A simple random sample of 233 participants, with 95% Confidence Interval (CI) and, a 4% margin of error, was calculated for a population of 1,564 prisoners. The relationship between sociodemographic and clinical variables was evaluated, considering as outcome of the rapid test for anti-HCV results, using the associative measure Prevalence Ratio (PR) with a 95% CI. Results: 240 people participated. The prevalence of anti-HCV was 2%, and the use of injectable drugs (PR 14.75; PRIC95% 2.09-104.28), being born in the decades of 1951 to 1980 (PR 9.28; PRIC95% 1.06-81.57) and be co-infected with hepatitis B virus (PR 10.75; PRIC95% 1.66-69.65) were the aspects that presented a relevant prevalence ratio for the presence of the virus, which could be generalized to the population. Conclusion: This is a population that is difficult to access, the study is relevant because it contributes to preventive measures of public health in the prison system. Moreover, it shows the need to implement measures to prevent and contain the spread of HCV, aiming at the elimination of hepatitis C in this population.
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ABSTRACT Background and aims: Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients and methods: Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included. Results: As previous treatments the distribution was: SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions. Conclusion: The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country.
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Resumo Objetivou-se relatar a experiência no gerenciamento de pesquisa-ação sobre inquérito de hepatite C junto à comunidade carcerária no Triângulo Mineiro, Minas Gerais. A proposta foi desenvolvida entre março de 2019 e março de 2020, alcançando 240 pessoas, com o intuito de conter a disseminação do agravo por meio de inquérito, testagem e acompanhamento dos casos positivos. Adotou-se ação intersetorial, com articulação entre universidades, sociedade médica, hospital de ensino e Secretaria de Estado de Justiça e Segurança Pública. As estratégias para o gerenciamento da pesquisa-ação foram: cenários e atores do estudo, registro e formalização da atividade, aplicação dos testes e manejo dos internos reagentes. Dificuldades foram identificadas quanto à acomodação de rotinas entre equipe de pesquisadores e funcionamento próprio da penitenciária, o que exigiu treinamento ostensivo entre as partes e articulações gerenciais. Considera-se que o relato, quando destaca as estratégias adotadas para a condução da pesquisa, colabora para a organização de investigações futuras que visem acessar essa população ainda invisibilizada.
Abstract We aimed to report the experience in managing action research on hepatitis C investigation in the prison community in the Triângulo Mineiro region, Minas Gerais, Brazil. The proposal was developed from March 2019 to March 2020, reaching 240 people to contain the spread of the disease through a survey, testing, and monitoring of positive cases. We adopted intersectoral action with articulation between Universities, Medical Society, Teaching Hospital, and State Secretariat for Justice and Public Security. Strategies for the management of action research are described: study settings and stakeholders, registration and formalization of the activity, application of tests, and management of reagent inmates. We identified difficulties regarding the accommodation of routines among the research team and the proper functioning of the penitentiary, which required extensive training between the parties and managerial articulations. We consider that the report collaborates with the organization of future research aimed at accessing this still invisible population, the prison community when it highlights the strategies adopted to conduct the research.
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Abstract INTRODUCTION: The prevalence of hepatitis C virus (HCV) infection is affected by demographic, virological, clinical, and lifestyle-related factors and varies in different regions in Brazil or worldwide. The present study aimed to clarify the epidemiological patterns of HCV infection in the interior region of Brazil. METHODS: This study was conducted in the Southern Triangle Macro-region of the state of Minas Gerais, Brazil, according to the guidelines of the National Program for the Prevention and Control of Viral Hepatitis. The participants answered a structured questionnaire on social and epidemiological factors. Immunochromatographic rapid tests were used for the qualitative detection of antibodies against HCV in whole blood (Alere HCV® Code 02FK10) in adult subjects by a free-standing method. RESULTS: Of 24,085 tested individuals, 184 (0.76%) were anti-HCV positive. The majority of anti-HCV-positive individuals were born between 1951 and 1980 (n=146 [79.3%]), with 68 women and 116 men. Identified risk factors included syringe and/or needle sharing (p = 0.003), being in prison (p = 0.004), and having tattoos or piercings (p = 0.005) and were significantly associated with the decade of birth. CONCLUSIONS: The study shows the importance of testing populations at risk for HCV infection, including incarcerated individuals, those with tattoos or piercings, those who share or have shared syringes or needles, and those in high-risk birth cohorts (1950s, 1960s, and 1970s) in the Southern Triangle Macro-region.
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Humanos , Masculino , Feminino , Adulto , Idoso , Idoso de 80 Anos ou mais , Adulto Jovem , Hepatite C/epidemiologia , Hepacivirus/imunologia , Anticorpos Anti-Hepatite C/sangue , Brasil/epidemiologia , Prevalência , Estudos Transversais , Fatores de Risco , Hepatite C/diagnóstico , Monitoramento Epidemiológico , Pessoa de Meia-IdadeRESUMO
A hepatopatia crônica causada pelo vírus da hepatite C (HCV) é a indicação mais comum de transplante hepático no mundo. A recorrência da hepatite C após o transplante hepático é elevada e em grande parte dos pacientes pode evoluir com cirrose e perda do enxerto de forma acelerada. Relatamos caso de portadora de cirrose por hepatite C genótipo 1a, tratada durante sete semanas com Interferon Peguilado e Ribavirina, em Resposta Viral Sustentada (RVS), mesmo após transplante hepático por hepatocarcinoma.
Chronic liver disease caused by hepatitis C virus (HCV) is the most common indication for liver transplantation in the world. The recurrence of hepatitis C after liver transplantation is high and most patients can develop cirrhosis and graft loss in an accelerated manner. A case of a patient with cirrhosis due to hepatitis C genotype 1a, treated for seven weeks with pegylated interferon and Ribavirin in Sustained Viral Response (SVR), even after liver transplantation for hepatocellular carcinoma.
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Humanos , Feminino , Idoso , Ribavirina , Transplante de Fígado , Interferon-alfa , Carcinoma Hepatocelular , Hepatite C Crônica , Resposta Viral Sustentada , Cirrose HepáticaRESUMO
Objetivo: Avaliar o consumo de recursos relacionado ao tratamento de pacientes cirróticos com o vírus da Hepatite C (HCV) genótipo 1 (G1) e compará-lo ao de pacientes com cirrose não relacionada ao HCV no SUS. Métodos: Foram levantadas no banco de dados do DataSUS as hospitalizações por CID de cirrose entre 2008 e 2012. Dentre estas hospitalizações, foram levantados os pacientes com histórico de tratamento com interferon peguilado, no mesmo período, para identificar pacientescom HCV G1 prévia, como definido pelo Protocolo Clínico e Diretrizes Terapêuticas (PCDT) do SUS. As coortes de pacientes com ou sem HCV prévio (CH+HCV e CH-HCV) foram acompanhadas por 60 meses e comparadas em termos de uso de recursos. Para a avaliação econômica, custos unitários de medicamentos foram analisados a partir do Portal de Compras Governamentais e, para valoração de hospitalizações, a partir do DataSUS. Resultados: Gastos com hospitalização de pacientes cirróticossomaram aproximadamente R$ 108 milhões em 2012, podendo ser observado um aumento de 75% no gasto comparado a 2008. A maioria dos pacientes internados por CH com ou sem HCV estava entre as idades de 45 e 64 anos, sendo a média de idade de 52 anos, e grande parte do gênero masculino. Os gastos médios com hospitalizações por paciente foram de R$ 6.583,00 nos pacientes do grupo CH+HCV versus R$ 3.496,00 nos pacientes do grupo CH-HCV (p < 0,001). Aproximadamente 5% dos pacientes CH-HCV receberam transplante hepático comparado com 7% dospacientes CH+HCV. O custo relacionado ao transplante na população CH+HCV representou 78% do custo total contra 67% dos pacientes CH-HCV, sendo o custo médio atribuído a transplantes nos pacientes CH+HCV 17% superior à população sem HCV. Conclusão: Os custos hospitalares entre os pacientes cirróticos relacionados ou não ao HCV apresentaram uma distribuição diferente entre si e significativa para a perspectiva do SUS.
Objective: Evaluate resource consumption related to the treatment of cirrhotic patients with hepatitis C virus (HCV) genotype 1 (G1) and compare to patients with cirrhosis not related to HCV in the Brazilian public healthcare system (SUS). Methods: Hospitalizations for the diagnosis of cirrhosis were obtained from DatasSUS between 2008 and 2012. Among these hospitalizations, patients with a history of treatment with pegylated interferon in the same period were evaluated, to identify patients with previous HCV G1, as defined by the Clinical Protocol and Therapeutic Guideline (PCDT)from SUS. The cohorts of patients with or without previous HCV (CH+HCV and CH-HCV) were followed for 60 months and compared in terms of resource use. For the economic evaluation, unit costs of medications were analyzed based on the Government Procurement Portal and costs of hospitalization from DataSUS. Results: Hospitalization expenditures of cirrhotic patients totaled approximately R$108 million in 2012, with an increase of 75% in spending compared to 2008. Most patients admitted for CH with or without HCV were between the ages of 45 and 64 years, with a mean age of 52 years and were mostly male. Approximately 5% of patients CH-HCV received liver transplantation compared to 7% of patients CH+HCV. Costs related to transplantation in the CH+HCV populationaccounted for 78% of the total cost compared to 67% among CH-HCV patients, being the average transplantation cost 17% higher in patients CH+HCV when compared to the population without HCV. Conclusion: Hospitalization costs among cirrhotic patients with or without prior treatment of HCV showed a different distribution and differences were significant for the SUS perspective.