1.
Org Biomol Chem
; 17(17): 4204-4207, 2019 04 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30938397
RESUMO
Arylureido-backbone containing peptoid-like trimers were prepared using the one-bead-one-compound approach. Isobaric molecules were synthesized from isocyanate precursors that contain alkyl halide handles at the ortho and para-positions in the phenyl ring. After chain extension with a primary amine, the piperazine-capped molecules were sequenced using tandem mass spectrometry and successfully identified based on their fragmentation pattern without a need for internal molecular encoding.