Water use and acute diarrhoeal illness in children in a United States metropolitan area.

We examined the association between water exposures and acute diarrhoeal illness (ADI) in children under non-outbreak conditions in a major US metropolitan area. We used a nested case-control study of children seen in an urban/suburban emergency department. Cases were those seen for a complaint of diarrhoea, while controls were age-matched children with a non-gastrointestinal complaint. Parents of subjects completed a validated water-use survey. Stratum-specific adjusted odds ratios (aOR) were calculated for the three main water effects: water source [surface vs. ground (well)], drinking-water type (tap vs. bottled), and use of water filters. Of 2472 subjects, 45% drank mostly or only bottled water. Well-water use was associated with increased odds of ADI compared to surface water [aOR 1·38, 95% confidence interval (CI) 1·01-1·87]. Use of bottled water did not affect the odds of ADI in well-water users, but increased the odds of ADI for surface-water users (aOR 1·27, 95% CI 1·02-1·57). We conclude that well-water use and bottled-water use are associated with increased odds of ADI in children.

A new method for the noninvasive determination of abdominal muscle feedforward activity based on tissue velocity information from tissue Doppler imaging.

Rapid arm movements elicit anticipatory activation of the deep-lying abdominal muscles; this appears modified in back pain, but the invasive technique used for its assessment [fine-wire electromyography (EMG)] has precluded its widespread investigation. We examined whether tissue-velocity changes recorded with ultrasound (M-mode) tissue Doppler imaging (TDI) provided a viable noninvasive alternative. Fourteen healthy subjects rapidly flexed, extended, and abducted the shoulder; recordings were made of medial deltoid (MD) surface EMG and of fine-wire EMG and TDI tissue-velocity changes of the contralateral transversus abdominis, obliquus internus, and obliquus externus. Muscle onsets were determined by blinded visual analysis of EMG and TDI data. TDI could not distinguish between the relative activation of the three muscles, so in subsequent analyses only the onset of the earliest abdominal muscle activity was used. The latter occurred <50 ms after the onset of medial deltoid EMG (i.e., was feedforward) and correlated with the corresponding EMG onsets (r = 0.47, P < 0.0001). The mean difference between methods was 20 ms and was likely explained by electromechanical delay; limits of agreement were wide (-40 to +80 ms) but no greater than those typical of repeated measurements using either technique. The between-day standard error of measurement of the TDI onsets (examined in 16 further subjects) was 16 ms. TDI yielded reliable and valid measures of the earliest onset of feedforward activity within the anterolateral abdominal muscle group. The method can be used to assess muscle dysfunction in large groups of back-pain patients and may also be suitable for the noninvasive analysis of other deep-lying or small/thin muscles.

Effect of ambient temperature on capillary refill in healthy children.

OBJECTIVES: To assess the effect of moderately decreased ambient temperature on capillary refill (CR) time in healthy children, and to measure the reliability of CR measurements between observers. DESIGN: Prospective interventional study with cross-over design. SETTING: Urban pediatric emergency department. PARTICIPANTS: 32 well-hydrated children aged 1 month to 12 years brought to the emergency department for care of minor illness or injury. INTERVENTIONS: Participants were assigned in random order to a 15-minute waiting period in each of two rooms, with and without air-conditioning (cool and warm rooms, respectively). At the end of each waiting period, fingertip CR was measured with a stopwatch, three times by each of one or more three trained observers. RESULTS: Mean CR time was 0.85 +/- 0.45 seconds in the warm room (mean ambient temperature (25.7 degrees C) vs 2.39 +/- 0.76 seconds in the cool room (mean temperature 19.4 degrees C). The mean overall difference in CR time between the two environments was 1.53 seconds (95% confidence interval [CI]: 1.31, 1.75; P < .001); the difference was significant regardless of age or sequence of exposure. 100% of patients were considered to have normal CR (less than 2 seconds) in the warm room, whereas only 31% were considered normal in the cool room. In the 16 patients with CR measured by three observers, interobserver reliability was fair, with an intraclass correlation coefficient of 0.70 (95% CI: 0.56, 0.85), and kappa of 0.54 (95% CI: 0.33, 0.73). CONCLUSIONS: Decreases in ambient temperature within a range found in typical office/emergency department settings may cause significant prolongation of CR time in children with normal circulatory status. There is marked interobserver variability in the measurement of CR even when performed by experienced observers. These findings suggest limitations to the use of CR in the assessment of ill or injured children.

Lack of association between neutropenia and the incidence of bacteremia associated with indwelling central venous catheters in febrile pediatric cancer patients.

To assess the incidence of bacteremia in pediatric cancer patients with indwelling central venous catheters with fever, we reviewed the records of all 67 such patients sequentially admitted during a 10-month period at our institution. There were a total of 140 episodes of fever in these 67 patients. In 55 of the episodes (39%) patients were nonneutropenic (absolute neutrophil count, greater than 500/mm3); 85 episodes (61%) were associated with neutropenia. Twenty-four percent of all episodes of fever in nonneutropenic patients were related to bacteremia vs. 9.5% of episodes of fever in the presence of neutropenia (P less than 0.05). When clinical evidence of an exit site infection was absent, the incidence of bacteremia in the neutropenic and nonneutropenic groups was similar (11% in the neutropenic group; 10% in the nonneutropenic group). We conclude that bacteremia is frequently observed in febrile pediatric cancer patients with indwelling venous catheters who are not neutropenic, particularly if there is clinical evidence of an exit site infection. Thus empiric antibiotic therapy is warranted in all pediatric oncology patients with indwelling catheters who develop fever.

Clinical decision rule to identify febrile young girls at risk for urinary tract infection.

OBJECTIVE: To develop a clinical prediction rule to identify febrile young girls needing urine culture for evaluation of urinary tract infection (UTI). DESIGN: Prospective cohort study. SETTING: Urban children's hospital emergency department. PATIENTS: All girls younger than 2 years (N = 1469) presenting to the emergency department with fever (temperature > or =38.3 degrees C) and without an unequivocal source of fever during a 12-month period. MAIN OUTCOME MEASURES: The outcome of interest was UTI, defined as a catheterized urine culture with pure growth of 10(4) colonies/mL or greater. Candidate predictors included demographic, historical, and physical examination variables. Clinical prediction rules were developed using multiple logistic regression after screening variables for univariate association and reliability. RESULTS: The presence of 2 or more of the following 5 variables-less than 12 months old, white race, temperature of 39.0 degrees C or higher, fever for 2 days or more, and absence of another source of fever on examination-predicted UTI with a sensitivity of 0.95 (95% confidence interval, 0.85-0.99) and a specificity of 0.31 (95% confidence interval, 0.28-0.34). In the study population, with an overall prevalence of UTI of 4.3%, the positive predictive value of a score of 2 or more was 6.4% and the negative predictive value of a score of less than 2 was 0.8%. CONCLUSION: Using this clinical decision rule, a strategy of obtaining urine cultures from girls younger than 2 years with a score of 2 or more would lead to identification of 95% of children with UTI and elimination of 30% of unnecessary urine cultures.

Epiglottitis in children, 1979 through 1992. Effects of Haemophilus influenzae type b immunization.

OBJECTIVE: To examine secular trends in the epidemiology, bacteriology, and clinical presentation of acute epiglottitis in children in the years surrounding the introduction of vaccine against Haemophilus influenzae type b. DESIGN: Retrospective chart review of patient series. SETTING: Large, urban, tertiary care pediatric hospital. SUBJECTS: One hundred forty-two children with epiglottitis admitted during a 14-year period (1979 through 1992). MAIN RESULTS: The average annual incidence of epiglottitis declined from 10.9 per 10,000 admissions before 1990 to 1.8 per 10,000 admissions from 1990 through 1992. The median age increased from 35.5 months in the earlier period to 80.5 months (P = .007). Overall, H influenzae type b was identified as the causative organism in 76% of patients, but in only 25% of the cases since 1990 (P = .004). Of the eight cases from 1990 through 1992, three had group A beta-hemolytic streptococcus isolated from a surface culture of the epiglottis; three other cases of group A beta-hemolytic streptococcus were identified earlier. These patients were significantly older than those with H influenzae type b disease (117.5 vs 35 months, P = .004). No important differences were found in any of a number of clinical characteristics based on causative organism or year of diagnosis. CONCLUSION: Acute epiglottitis has diminished in frequency since 1990. Patients whose conditions have been diagnosed since then tend to be older and to have disease caused by organisms other than H influenzae type b (particularly group A beta-hemolytic streptococcus). However, the clinical presentation appears to be similar to that seen previously.

Immunologic changes after blood transfusion in patients undergoing vascular surgery.

Immunologic changes after blood transfusions cannot be studied ethically in normal individuals. We therefore studied two comparable groups of patients with atherosclerotic cardiovascular disease who received similar drug treatment and experienced a similar degree of surgical trauma, except that one group received an average of 2.5 units of packed red cells at one time period during surgery. We conducted immunologic tests preoperatively and 5, 10, 45 to 60, 90, 180, and 360 days postoperatively. There was no significant difference in all indices tested preoperatively between the two groups. Five and 10 days postoperatively, the absolute numbers of CD3, CD4, CD8, and B cells decreased in both groups; however, the decrease was significantly greater in the transfused group than in the nontransfused group 5 days postoperatively. There was no significant difference in these parameters between the two groups at other time periods tested. At 5 and 10 days postoperatively, the lymphocyte responses to phytohemagglutinin, concanavalin A, and allogeneic lymphocytes in autologous serum were decreased in both groups. However, at 60 days postoperatively, the responses of the nontransfused group became significantly increased, whereas those of the transfused group remained relatively unchanged. By days 90, 180, and 360, the lymphocyte responses of the nontransfused group had dropped to levels seen at earlier time intervals and were comparable to responses in the transfused group. There were no significant differences between the groups in the number of T-cell colonies formed, the number of immunoglobulin-producing cells obtained, and the lymphokine responses (migration inhibitory factor/migration stimulation factor) at all times tested. The major immunologic perturbations attributed to blood transfusions were an exaggerated decrease in the numbers of circulating lymphocytes, particularly those with markers associated with T-helper cells, and failure to demonstrate a rebound increase in the proliferative response 45 to 90 days later.

Pediatric emergency assessment tool (PEAT): a risk-adjustment measure for pediatric emergency patients.

OBJECTIVE: To develop a multivariable model predicting the level of care required by pediatric patients for use as a risk-adjustment tool in the evaluation of emergency medical services for children. METHODS: A random 10% sample of records of all visits over a 12-month period to a suburban, university-affiliated pediatric emergency department (PED) was selected and abstracted. The outcome variable, level of care received, was categorized in three levels: routine care only (R); diagnostic or therapeutic procedures performed in the ED but patient not admitted (EDT); and admission to hospital (ADM). Predictor variables included information routinely elicited and recorded at the time of triage. Using multinomial logistic regression, a predictive model was derived from a subset of 70% of the selected visits, and was validated in the remaining 30%. RESULTS: The total sample included 2,287 visits. The overall rate of each outcome was R-37%, EDT-53%, and ADM-10%. The final regression model included the following predictors significantly associated with the outcome: age, past medical history, temperature, abnormal respiratory rate or pulse oximetry in triage, chief complaint, and triage level (model likelihood ratio chi-square, 14 df = 332, p < 0.00001, R(2) = 0.14). The number of outcomes was well predicted by the model in both subsamples. Analysis of variance showed a significant association between Pediatric Emergency Assessment Tool (PEAT) score (weighted sum of the predicted probabilities of EDT and ADM) and both ED charges and time spent in the ED (p < 0.001). CONCLUSIONS: A model based on easily and routinely measured variables can accurately predict the level of care rendered in the PED. The predicted probabilities from such a model correlate well with other outcomes of care and may be useful in adjusting for differences in risk when evaluating quality of care.

Urinary tract infection in the pediatric patient.

Little attention has been focused on the identification of urinary tract infection (UTI) in young febrile children in the emergency department, despite recent information that suggests both a high prevalence and significant associated morbidity in this population. Most UTIs that lead to scarring or diminished kidney growth occur in children younger than age 4 years, especially babies in the first year of life. Overall, prevalence rates of UTI in febrile infants in the emergency department are approximately 3% to 5%, with higher rates for white girls, uncircumcised boys, and those without another potential source for fever. Prevalence and risk factors are given so that clinicians may identify those febrile children at particularly high or low risk of UTI for selective management. Culturing methods, urine screening tests, and culture interpretation are reviewed and management strategies based on these results are suggested.

ABO-incompatible living related donor kidney transplantation: report of two cases.

The courses of two recipients of ABO-incompatible HLA-identical living related donor kidney transplants are described, the first an A into O and the second a B into A. Both patients were prepared by a month of preoperative azathioprine and a week of plasmapheresis to reduce isohemagglutinin titers in one to 1:2 and in the other to 0 at the time of transplant. Both had early mild steroid-reversible rejections, and the first patient has had an uneventful subsequent course 20 months postgrafting on low-dose cyclosporine and prednisone. The second patient developed a further immunologic event at 1 month that may have been isohemagglutinin mediated or may have been rejection but subsided with OKT3 therapy and plasmapheresis. She lost her graft at 5 months despite normal function during attempts to repair a ureteric fibrosis. Neither patient had donor-specific transfusion or splenectomy. This approach is feasible and should be considered for those patients having related but ABO-incompatible donors.

Short-duration fatigue alters neuromuscular coordination of trunk musculature: implications for injury.

The aim of this investigation was to determine the effect of muscle fatigue, produced by two different fatigue protocols, on the coordination of trunk and thigh muscles during the performance of a manual-handling task (e.g. a weighted stoop lift). The two fatigue protocols were designed to produce either (a) a non-specific widespread fatigue of trunk and limb muscles (e.g. rowing fatigue protocol), or (b) a specific fatigue of the trunk extensor musculature (e.g. back extension fatigue protocol). Specifically, we wished to determine whether the coordination of trunk muscles during a stoop lift was compromised more, or less, by either of these two fatigue protocols. Ten male subjects (20-24 years) were tested utilising an electromyographic technique which collected electromyograms from trunk flexor and extensor muscles, as well as the Hamstring muscle group, during a pre- and a post-fatigue performance of a weighted stoop lift. The results showed that the back extension fatigue protocol, but not the rowing fatigue protocol, produced significant (p<0.05) changes in the timing of trunk muscle activation during a stoop lift. The longer periods of muscle activation seen only after the back extension fatigue protocol, suggested that fatigue of these muscles had required the CNS to alter their periods of activation to a pattern similar to that previously seen in elderly populations. The results also suggested that intense short-duration motor tasks, which may differentially target the back and its musculature, could leave the spine susceptible to increased risk of injury even though worker perceptions of general fatigue are low. Risk assessment guidelines for manual handling should consider not only the weight and frequency of the lift, but lift duration as well to maintain worker safety.

Development of a German version of the knee outcome survey for daily activities.

INTRODUCTION: The knee outcome survey-activities of daily living scale (KOS-ADLS) is a patient-reported specific measure of knee function. The KOS-ADLS includes items related to both symptoms and functional limitations experienced during ADL. The purpose of this study was to examine the reliability and validity of a cross-culturally adapted German version of the KOS-ADLS. MATERIALS AND METHODS: 108 consecutive knee patients (n = 57 males/51 females) scheduled for outpatient physical therapy at an orthopedic hospital were enrolled in the investigation. For the reliability analysis, 50 patients were asked to complete the questionnaire on two non-consecutive days. To assess the validity of the KOS-ADLS, 58 additional patients answered the questionnaire in addition to performing a series of other related tests: (1) visual analogue scale for knee pain intensity, (2) The Get-up-and Go, and (3) time for ascending/descending stairs. The functional tests were selected because they directly related to specific items in the questionnaire and were thought to reflect the major areas of disability for this patient group. RESULTS: The reliability analysis demonstrated that the German version of the KOS-ADLS had a good reliability (ICC range 0.94-0.97) and internal consistency (alpha 0.89). The functional tests (e.g. Get-up and Go, ascending/descending stairs) showed moderate correlations, whereas the visual analogue pain scale was highly correlated with the subscores and total score of the KOS-ADLS. CONCLUSION: The psychometric characteristics of the German version of the KOS-ADLS produced reliable and valid results, as the original version, in detection of an individual's symptom and function related knee joint impairment.

Mechanomyographic assessment of contractile properties within seven segments of the human deltoid muscle.

The aim of this study was to determine, by a non-invasive whole muscle mechanomyographic technique (wMMG), how muscle segment contractile properties varied within the segments of the multifunctional deltoid muscle, and how such variations in contractile properties may reflect the muscle segment's function and fibre type composition. We hypothesised that muscle segment contractile properties, consistent with slower twitch muscle fibre populations, would be associated with the deltoid's prime mover abductor muscle segment (middle head), rather than the prime mover flexor and extensor muscle segments (anterior and posterior heads). Eighteen healthy and athletic University students (nine males and nine females; mean age 20-24 years) volunteered for this study. Each subject's right upper limb was secured with the forearm flexed to 30 degrees and the shoulder in 45 degrees of abduction. The wMMG laser sensor was positioned perpendicular to the middle of each muscle segment, to record the involuntary lateral displacement of the muscle belly following a maximal, single twitch, percutaneous neuromuscular stimulation (PNS) [180 V (max.); 80 mA (max.); 50 mus]. Ten trials were recorded from each of the seven deltoid segments for a total of 70 trials per subject. From each segment, eight variables were analysed from the recorded wMMG waveforms; maximal displacement (D (max)); delay time (T (d)); contraction time (T (c)); sustain time (T (s)); relaxation time (T (r)) and half relaxation time ((1/2)T (r)), average rate of contraction (ARC) and the average rate of relaxation (ARR). The results indicated that the contractile properties of the seven segments of the deltoid muscle showed significant (P < 0.05) variation in a medial to lateral direction. Medially the strap-like segments of the anterior (S1, S2) and posterior heads (S4-S7), with larger moment arms for shoulder flexion and extension respectively, had the fastest contractile properties. In contrast the multipennate segment 3, with the largest moment arm for shoulder abduction, had the slowest contractile properties (P < 0.05). Muscle segment contractile properties were matched to the biomechanical and architectural characteristics of the individual muscle segments.

Screening tests for urinary tract infection in children: A meta-analysis.

OBJECTIVE: To review systematically and to summarize the existing literature regarding performance of rapid diagnostic tests for urinary tract infection (UTI) in children. DESIGN: Systematic review and meta-analysis. METHODS: Published articles reporting the performance of urine dipstick tests (leukocyte esterase [LE] and/or nitrite), Gram stain, or microscopic analysis of spun or unspun urine in the diagnosis of UTI in children 5 white blood cells/high-power field in a centrifuged urine sample, the TPR was 0.67 and the FPR was 0.21, whereas for >10 white blood cells per mm(3) in uncentrifuged urine, the TPR was 0.77 and the FPR was 0.11. CONCLUSIONS: Both Gram stain and dipstick analysis for nitrite and LE perform similarly in detecting UTI in children and are superior to microscopic analysis for pyuria.

Short-term outcomes after acute treatment of pediatric asthma.

CONTEXT: The short-term course of pediatric patients after emergency department (ED) treatment for acute asthma has not been comprehensively documented; most previous studies have limited outcomes to ED length-of-stay, hospital admission, and relapse. OBJECTIVE: To describe symptom persistence, medication use, functional disability, follow-up, and relapse in these children in the 2 weeks after acute treatment and ED discharge. DESIGN: Randomly selected, prospective cohort from September 1996 to August 1997; follow-up telephone interviews at 1 and 2 weeks. Setting. A large, inner-city children's hospital emergency department. Patients. Random sample of pediatric asthma visits requiring ED treatment but not admission; 457 were eligible, 388 with complete follow-up (85%); final sample included 367 patients after multiple visits deleted. MAIN OUTCOME MEASURES: Details of symptom persistence, functional disability, medication use, relapse, and routine follow-up. RESULTS: Results included significant morbidity: 23% (95% confidence interval [CI]: 19, 27) with cough and 12% (95% CI: 9, 15) with wheeze persistent at 2 weeks; 20% (95% CI: 16, 24) with decreased activity at 1 week; 45% (95% CI: 39, 51) missed >2 and 24% (95% CI: 19, 29) >/=5 days of school or day care; 17% (95% CI: 13, 21) spent >/=3 days in bed; 54% (95% CI: 47, 60) of caretakers missed at least 1 and 18% (95% CI: 13, 24) missed >2 days of school or work; and 32% (95% CI: 28, 38) of patients were still using greater than baseline medication at 2 weeks. Reported relapse rates were averaged at 13% (95% CI: 10, 17) with 3% (95% CI: 1, 5) admitted. Routine office follow-up was poor: 29% (95% CI: 25, 34) had had a visit; 48% (95% CI: 43, 54) reported no visit/none planned. CONCLUSIONS: A considerable proportion of inner-city pediatric patients discharged from the hospital from the ED after standard treatment for acute asthma had poor short-term outcomes. Conventional markers of successful ED treatment, such as avoiding hospital admission or relapse, do not adequately describe outcomes of acute care. The patient-oriented measures described here may provide more useful indicators of outcome in the evaluation of acute asthma care.

Ambulance use by high-acuity patients in a pediatric ED.

The objective of this study was to analyze ambulance usage by highest acuity patients as compared with all patients in a suburban pediatric hospital ED. A 1-year retrospective records analysis was conducted of all highest acuity patients (those patients triaged as emergent or critical or admitted to the intensive care unit). A total of 245 patients made 270 high-acuity visits to the ED in 1995. Thirty-one (13%) of the high-acuity patients arrived via ambulance; the rest arrived via private vehicle. The 31 high-acuity patients constituted 8% of the total number of patients arriving by ambulance. There was no significant difference in ambulance usage between insurance groups in the high-acuity patients. Only high-acuity patients with neurologic symptoms (primarily seizures) had a greater relative use of EMS transportation, with 39% of these patients arriving via ambulance (odds ratio 6.6, 95% confidence interval 2.6,16.6). High-acuity patients account for the minority of total ambulance usage in our ED.

Salicylate and acetaminophen in donated blood.

Blood donors in Canada are asked to volunteer their history of drug ingestion within the previous 24 hours. The authors analysed 400 serum samples from blood donors for acetylsalicylic acid (ASA) and acetaminophen, two commonly used nonprescription drugs. Although 16 of the samples contained ASA and 10 acetaminophen (2 contained both drugs), none of the donors had volunteered that they had ingested those medications before donating blood. The possible role of these drugs in some of the unexplained reactions to transfusions is considered.