RESUMO
A new collection of evidence-based commentaries explores critical challenges facing scientists and policymakers working to address the potential environmental and health harms of microplastics. The commentaries reveal a pressing need to develop robust methods to detect, evaluate, and mitigate the impacts of this emerging contaminant, most recently found in human placentas.
Assuntos
Monitoramento Ambiental/métodos , Poluição Ambiental/análise , Plásticos/toxicidade , Recuperação e Remediação Ambiental/métodos , Humanos , Microplásticos/toxicidade , Saúde PúblicaRESUMO
This Editorial introduces a Collection of articles in which the authors explore the challenges and pitfalls of communicating the science of climate change in an atmosphere where evidence doesn't matter.
Assuntos
Mudança Climática , Negação em Psicologia , Animais , Organismos Aquáticos , Regiões Árticas , Comunicação , HumanosAssuntos
Compostos Benzidrílicos/efeitos adversos , Estrogênios não Esteroides/efeitos adversos , Fenóis/efeitos adversos , Reprodução/efeitos dos fármacos , Animais , Caenorhabditis elegans , Carcinógenos , Dietilestilbestrol , Exposição Ambiental/efeitos adversos , Feminino , Alimentos em Conserva/efeitos adversos , Humanos , RatosRESUMO
Large-conductance calcium-activated potassium (BK) channels are ubiquitous and play an important role in a number of diseases. In hair cells of the ear, they play a critical role in electrical tuning, a mechanism of frequency discrimination. These channels show variable kinetics and expression along the tonotopic axis. Although the molecular underpinnings to its function in hair cells are poorly understood, it is established that BK channels consist of a pore-forming α-subunit (Slo) and a number of accessory subunits. Here we identify CDK5, a member of the cyclin-dependent kinase family, as an interacting partner of Slo. We show CDK5 to be present in hair cells and expressed in high concentrations in the cuticular plate and in the circumferential zone. In human embryonic kidney cells, we show that CDK5 inhibits surface expression of Slo by direct phosphorylation of Slo. Similarly, we note that CDK5 affects Slo voltage activation and deactivation kinetics, by a direct phosphorylation of T847. Taken together with its increasing expression along the tonotopic axis, these data suggest that CDK5 likely plays a critical role in electrical tuning and surface expression of Slo in hair cells.
Assuntos
Cóclea/metabolismo , Quinase 5 Dependente de Ciclina/metabolismo , Células Ciliadas Auditivas/metabolismo , Subunidades alfa do Canal de Potássio Ativado por Cálcio de Condutância Alta/metabolismo , Animais , Sinalização do Cálcio/fisiologia , Membrana Celular/genética , Membrana Celular/metabolismo , Galinhas , Transferência Ressonante de Energia de Fluorescência , Biblioteca Gênica , Células HEK293 , Humanos , Subunidades alfa do Canal de Potássio Ativado por Cálcio de Condutância Alta/genética , Potenciais da Membrana/fisiologia , Técnicas de Patch-Clamp , Fosforilação , Técnicas do Sistema de Duplo-Híbrido , Xenopus laevisRESUMO
Researchers say that endocrine-disrupting chemicals can permanently damage the developing organism and may even promote obesity. But the chemical industry doesn't want you to believe them.