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1.
World J Clin Cases ; 10(18): 6069-6081, 2022 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-35949840

RESUMO

BACKGROUND: Icotinib could have potential effect and tolerability when used sequentially with chemotherapy for advanced epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). AIM: To evaluate the efficacy and safety of chemotherapy followed by icotinib maintenance therapy as first-line treatment for advanced EGFR-mutated NSCLC. METHODS: This multicenter, open-label, pilot randomized controlled trial enrolled 68 EGFR-mutated stage IIIB/IV NSCLC patients randomized 2:3 to the icotinib alone and chemotherapy + icotinib groups. RESULTS: The median progression-free survival in the icotinib alone and chemotherapy + icotinib groups was 8.0 mo (95%CI: 3.84-11.63) and 13.4 mo (95%CI: 10.18-16.33), respectively (P = 0.0249). No significant differences were found in the curative effect when considering different cycles of chemotherapy or chemotherapy regimen (all P > 0.05). CONCLUSION: A sequential combination of chemotherapy and EGFR-tyrosine kinase inhibitor is feasible for stage IV EGFR-mutated NSCLC patients.

2.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 25(11): 980-2, 2005 Nov.
Artigo em Zh | MEDLINE | ID: mdl-16355611

RESUMO

OBJECTIVE: To evaluate the clinical efficacy and side effects of Shelian capsule (SLC) as adjuvant of embolismic chemotherapy on primary hepatic carcinoma. METHODS: One hundred and twenty patients with hepatic carcinoma were conducted arterial embolismic chemotherapy with FAM program for two therapeutic cycles. The 60 patients in the treated group were taken SLC orally for auxiliary treatment, and the other 60 in the control group were given glucurolactone instead. The tumor size, Karnofsky score, clinical symptoms, alpha fetoprotein (AFP), NK cell, T cell-subgroup and adverse effect before and after treatment between the two groups were compared respectively. RESULTS: As compared with the control group, in the treated group the Karnofsky score was better ((P < 0.05) and the remission rate of clinical symptom were superior (66.7% vs 88.3 %, P < 0.05). The ratio of CD4/CD8 and NK cell activity was significantly different between the two groups (P<0.05). There was no obvious adverse effect in the treated group. CONCLUSION: SLC can effectively enhance the immunity of patients with tumor, remit clinical symptoms, improve quality of life and without any side effects.


Assuntos
Adjuvantes Imunológicos/uso terapêutico , Carcinoma Hepatocelular/terapia , Quimioembolização Terapêutica , Medicamentos de Ervas Chinesas/uso terapêutico , Neoplasias Hepáticas/terapia , Fitoterapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Cápsulas , Carcinoma Hepatocelular/imunologia , Terapia Combinada , Doxorrubicina/administração & dosagem , Feminino , Fluoruracila/administração & dosagem , Humanos , Neoplasias Hepáticas/imunologia , Masculino , Pessoa de Meia-Idade , Mitomicina/administração & dosagem
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