RESUMO
Cases of glioblastoma multiforme (GBM) metastasizing to the leptomeninges or the intramedullary spine are rare and their prognosis are relatively poor. We present a case of supratentorial glioblastoma WHO grade IV which was later diagnosed to have cervical intramedullary metastasis 7 months after the primary surgery.
Assuntos
Neoplasias Encefálicas , Medula Cervical , Craniotomia/métodos , Glioblastoma/secundário , Laminectomia/métodos , Lobo Parietal , Neoplasias da Medula Espinal , Lobo Temporal , Adulto , Antineoplásicos/uso terapêutico , Protocolos Antineoplásicos , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/fisiopatologia , Neoplasias Encefálicas/cirurgia , Medula Cervical/diagnóstico por imagem , Medula Cervical/cirurgia , Descompressão Cirúrgica/métodos , Evolução Fatal , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Estadiamento de Neoplasias , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/cirurgia , Radioterapia/métodos , Neoplasias da Medula Espinal/diagnóstico , Neoplasias da Medula Espinal/fisiopatologia , Neoplasias da Medula Espinal/secundário , Neoplasias da Medula Espinal/cirurgia , Técnicas Estereotáxicas , Lobo Temporal/diagnóstico por imagem , Lobo Temporal/cirurgia , Tomografia Computadorizada por Raios X/métodosRESUMO
The radiological abnormalities reported in CNS tuberculosis and their pathological correlates are discussed. Focal tuberculous involvement of the CNS without formation of tuberculoma is rare. The MR features in this case were also distinctly unusual for CNS tuberculosis. Therefore, histological confirmation of all lesions thought to be a low grade glioma is mandatory.
Assuntos
Encefalopatias/diagnóstico , Imageamento por Ressonância Magnética , Tuberculose do Sistema Nervoso Central/diagnóstico , Encefalopatias/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Tuberculose do Sistema Nervoso Central/patologiaRESUMO
Posttraumatic gliomas have been described, but in none of these has there been documented evidence of absence of tumour at the time of the injury. We report a case of post-traumatic malignant glioma with radiological evidence of only a contusion prior to the development of the tumour.
Assuntos
Neoplasias Encefálicas/etiologia , Traumatismos Craniocerebrais/complicações , Glioblastoma/etiologia , Lobo Temporal , Neoplasias Encefálicas/diagnóstico , Traumatismos Craniocerebrais/diagnóstico , Glioblastoma/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Lobo Temporal/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Temporary occlusion of major cerebral blood vessels occasionally becomes necessary during surgical procedures. Ascorbic acid (Vitamin C) is an important non-enzymatic scavenger of free radicals and its protective effect on the brain in permanent focal cerebral ischaemia has been proven in a primate model of focal cerebral ischaemia [16]. Additional damage caused by reperfusion of the infarcted area has been shown in the rat model [22]. This study was undertaken to study the efficacy of ascorbic acid in decreasing infarct size in ischaemic reperfused brain. Maccaca radiata monkeys in the treated group were given two grams of ascorbic acid, parentally immediately before clipping the middle cerebral artery and the control group was given placebo. Reperfusion was done after four hours. Mean infarct size in all the three brain slices in the ascorbic acid pretreated group was 7.3% +/- 2.7 and in the placebo group 22.1 +/- 6.7 under similar conditions. The mean infarct size in the ascorbic acid pretreated group of monkeys was significantly lower when compared with the placebo group (p = 0.0003).