Pesquisa | BVS Educação Profissional em Saúde

1.

First Approved Kinase Inhibitor for AML.

Rasko, John E J; Hughes, Timothy P.

Cell ; 171(5): 981, 2017 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-29149610

2.

Asciminib in Newly Diagnosed Chronic Myeloid Leukemia.

Hochhaus, Andreas; Wang, Jianxiang; Kim, Dong-Wook; Kim, Dennis Dong Hwan; Mayer, Jiri; Goh, Yeow-Tee; le Coutre, Philipp; Takahashi, Naoto; Kim, Inho; Etienne, Gabriel; Andorsky, David; Issa, Ghayas C; Larson, Richard A; Bombaci, Felice; Kapoor, Shruti; McCulloch, Tracey; Malek, Kamel; Yau, Lillian; Ifrah, Sophie; Hoch, Matthias; Cortes, Jorge E; Hughes, Timothy P.

N Engl J Med ; 2024 May 31.

Artigo em Inglês | MEDLINE | ID: mdl-38820078

3.

Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy.

Eadie, Laura N; Lagonik, Elias; Page, Elyse C; Schutz, Caitlin E; Heatley, Susan L; McClure, Barbara J; Forgione, Michelle Olivia; Yeung, David T; Hughes, Timothy P; White, Deborah L.

Blood ; 2024 Jun 07.

Artigo em Inglês | MEDLINE | ID: mdl-38848536

4.

Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy.

Pagani, Ilaria S; Shanmuganathan, Naranie; Dang, Phuong; Saunders, Verity A; Grose, Randall; Kok, Chung H; James, Jane; Tolland, Molly; Braley, Jodi A; Altamura, Haley K; Yeung, David T; Branford, Susan; Yong, Agnes S M; Hughes, Timothy P; Ross, David M.

Blood ; 142(25): 2192-2197, 2023 12 21.

Artigo em Inglês | MEDLINE | ID: mdl-37616555

5.

Asciminib: a new therapeutic option in chronic-phase CML with treatment failure.

Yeung, David T; Shanmuganathan, Naranie; Hughes, Timothy P.

Blood ; 139(24): 3474-3479, 2022 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-35468180

6.

Immune modulation in chronic myeloid leukaemia patients treated with nilotinib and interferon-alpha.

Irani, Yazad D; Hughes, Amy; Kok, Chung H; Clarson, Jade; Yeung, David T; Ross, David M; Branford, Susan; Hughes, Timothy P; Yong, Agnes S M.

Br J Haematol ; 202(6): 1127-1136, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37482935

7.

Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia.

Shanmuganathan, Naranie; Pagani, Ilaria S; Ross, David M; Park, Sahee; Yong, Agnes S M; Braley, Jodi A; Altamura, Haley K; Hiwase, Devendra K; Yeung, David T; Kim, Dong-Wook; Branford, Susan; Hughes, Timothy P.

Blood ; 137(9): 1196-1207, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-32871588

8.

A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs.

Réa, Delphine; Mauro, Michael J; Boquimpani, Carla; Minami, Yosuke; Lomaia, Elza; Voloshin, Sergey; Turkina, Anna; Kim, Dong-Wook; Apperley, Jane F; Abdo, Andre; Fogliatto, Laura Maria; Kim, Dennis Dong Hwan; le Coutre, Philipp; Saussele, Susanne; Annunziata, Mario; Hughes, Timothy P; Chaudhri, Naeem; Sasaki, Koji; Chee, Lynette; García-Gutiérrez, Valentin; Cortes, Jorge E; Aimone, Paola; Allepuz, Alex; Quenet, Sara; Bédoucha, Véronique; Hochhaus, Andreas.

Blood ; 138(21): 2031-2041, 2021 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-34407542

9.

Molecular response in newly diagnosed chronic-phase chronic myeloid leukemia: prediction modeling and pathway analysis.

Radich, Jerald P; Wall, Matthew; Branford, Susan; Campbell, Catarina D; Chaturvedi, Shalini; DeAngelo, Daniel J; Deininger, Michael; Guinney, Justin; Hochhaus, Andreas; Hughes, Timothy P; Kantarjian, Hagop M; Larson, Richard A; Li, Sai; Maegawa, Rodrigo; Mishra, Kaushal; Obourn, Vanessa; Pinilla-Ibarz, Javier; Purkayastha, Das; Sadek, Islam; Saglio, Giuseppe; Shrestha, Alok; White, Brian S; Druker, Brian J.

Haematologica ; 108(6): 1567-1578, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-36727397

10.

Impact of additional genetic abnormalities at diagnosis of chronic myeloid leukemia for first-line imatinib-treated patients receiving proactive treatment intervention.

Shanmuganathan, Naranie; Wadham, Carol; Shahrin, NurHezrin; Feng, Jinghua; Thomson, Daniel; Wang, Paul; Saunders, Verity; Kok, Chung Hoow; King, Rob M; Kenyon, Rosalie R; Lin, Ming; Pagani, Ilaria S; Ross, David M; Yong, Agnes S M; Grigg, Andrew P; Mills, Anthony K; Schwarer, Anthony P; Braley, Jodi; Altamura, Haley; Yeung, David T; Scott, Hamish S; Schreiber, Andreas W; Hughes, Timothy P; Branford, Susan.

Haematologica ; 108(9): 2380-2395, 2023 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-36951160

11.

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Wylie, Andrew A; Schoepfer, Joseph; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Loo, Alice; Furet, Pascal; Marzinzik, Andreas L; Pelle, Xavier; Donovan, Jerry; Zhu, Wenjing; Buonamici, Silvia; Hassan, A Quamrul; Lombardo, Franco; Iyer, Varsha; Palmer, Michael; Berellini, Giuliano; Dodd, Stephanie; Thohan, Sanjeev; Bitter, Hans; Branford, Susan; Ross, David M; Hughes, Timothy P; Petruzzelli, Lilli; Vanasse, K Gary; Warmuth, Markus; Hofmann, Francesco; Keen, Nicholas J; Sellers, William R.

Nature ; 543(7647): 733-737, 2017 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-28329763

12.

Asciminib for chronic myeloid leukaemia: Next questions.

Shanmuganathan, Naranie; Hughes, Timothy P.

Br J Haematol ; 199(3): 322-331, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35729850

13.

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.

Hughes, Timothy P; Mauro, Michael J; Cortes, Jorge E; Minami, Hironobu; Rea, Delphine; DeAngelo, Daniel J; Breccia, Massimo; Goh, Yeow-Tee; Talpaz, Moshe; Hochhaus, Andreas; le Coutre, Philipp; Ottmann, Oliver; Heinrich, Michael C; Steegmann, Juan L; Deininger, Michael W N; Janssen, Jeroen J W M; Mahon, Francois-Xavier; Minami, Yosuke; Yeung, David; Ross, David M; Tallman, Martin S; Park, Jae H; Druker, Brian J; Hynds, David; Duan, Yuyan; Meille, Christophe; Hourcade-Potelleret, Florence; Vanasse, K Gary; Lang, Fabian; Kim, Dong-Wook.

N Engl J Med ; 381(24): 2315-2326, 2019 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-31826340

14.

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers.

Krishnan, Vaidehi; Kim, Dennis Dong Hwan; Hughes, Timothy P; Branford, Susan; Ong, S Tiong.

Haematologica ; 107(2): 358-370, 2022 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-34615339

15.

Asciminib monotherapy for newly diagnosed chronic myeloid leukemia in chronic phase: the ASC4FIRST phase III trial.

Cortes, Jorge E; Hochhaus, Andreas; Takahashi, Naoto; Larson, Richard A; Issa, Ghayas C; Bombaci, Felice; Ramscar, Nicholas; Ifrah, Sophie; Hughes, Timothy P.

Future Oncol ; 18(38): 4161-4170, 2022 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-36524980

16.

Counterpoint: There is a best duration of deep molecular response for treatment-free remission, but it is patient-specific, and that is the challenge.

Ross, David M; Hughes, Timothy P.

Br J Haematol ; 192(1): 24-27, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33169882

17.

The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL.

Tavakoli Shirazi, Paniz; Eadie, Laura N; Heatley, Susan L; Hughes, Timothy P; Yeung, David T; White, Deborah L.

Br J Cancer ; 122(4): 455-464, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31792348

18.

Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased natural killer cells.

Irani, Yazad D; Hughes, Amy; Clarson, Jade; Kok, Chung H; Shanmuganathan, Naranie; White, Deborah L; Yeung, David T; Ross, David M; Hughes, Timothy P; Yong, Agnes S M.

Br J Haematol ; 191(3): 433-441, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32352166

19.

TARGET: a survey of real-world management of chronic myeloid leukaemia across 33 countries.

Turkina, Anna; Wang, Jianxiang; Mathews, Vikram; Saydam, Guray; Jung, Chul Won; Al Hashmi, Hani Hassan; Yassin, Mohamed; Le Clanche, Solenn; Miljkovic, Darko; Slader, Cassandra; Hughes, Timothy P.

Br J Haematol ; 190(6): 869-876, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32227648

20.

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

Hochhaus, Andreas; Larson, Richard A; Guilhot, François; Radich, Jerald P; Branford, Susan; Hughes, Timothy P; Baccarani, Michele; Deininger, Michael W; Cervantes, Francisco; Fujihara, Satoko; Ortmann, Christine-Elke; Menssen, Hans D; Kantarjian, Hagop; O'Brien, Stephen G; Druker, Brian J.

N Engl J Med ; 376(10): 917-927, 2017 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-28273028

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