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1.
Int J Surg ; 84: 194-198, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31945481

RESUMO

The Association of Surgeons in Training (ASiT) advocates for and represents surgical trainees throughout the United Kingdom and the Republic of Ireland. It promotes excellence in surgical training for the benefit of both surgeons and patients. Originally founded in 1976, ASiT is independent of the National Health Service (NHS), Surgical Royal Colleges, and Specialty Associations. The 2019 Annual Conference in Belfast hosted a record number of delegates (n = 855) over the 3-day educational weekend. The conference theme, "Innovation in Surgical Practice" focused on the latest educational and technological innovation to enhance trainee's knowledge and experience of surgical innovation to ultimately enhance patient care. A record number of technical and non-technical pre-conference courses (n = 13) covering a diverse range of topics was offered. A new feature, a 24-h Hackathon, was successfully delivered in parallel to the Conference. This opportunity generated productive, cross speciality collaboration, to address and solve current problems in healthcare. Over 1000 abstract submissions were received and there were over 30 poster and oral prizes on offer for winning submissions. The ASiT conference and the Association continues to grow annually and we look forward to welcoming delegates to Birmingham from the 6-8th March 2020 to enjoy another action packed weekend focused on "Optimising Performance".


Assuntos
Cirurgiões/educação , Humanos , Irlanda , Sociedades Médicas , Reino Unido
2.
Int J Surg ; 84: 199-206, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32169575

RESUMO

INTRODUCTION: Accurate recording of operative cases is essential during training to demonstrate experience. However, indicative numbers delineating minimum desirable experience may incentivise exaggeration or misrepresentation of experience. This study aimed to determine perceptions of real-world eLogbook use among UK surgeons in training. MATERIAL AND METHODS: An anonymous online questionnaire was disseminated electronically using a pre-planned yield-maximisation strategy, incorporating regional champions, email and social media. Evaluation employed mixed methods in a combined interpretation of quantitative and qualitative data from the questionnaire. Recommendations for development of the eLogbook were itemised from respondents' free text items and a modified Delphi process, conducted within the Council of the UK national trainee representative body, the Association of Surgeons in Training, determined the strength of each recommendation. RESULTS: Analysis included 906 complete responses from training-grade surgeons (34.8% female) from all UK recognised specialties and all grades of training. More than two-thirds (68.5%) believed that overstatement or misrepresentation of case involvement occurs. A fifth (20.8%) reported witnessing trainees logging cases they had not actually participated in and almost a third (32.7%) had witnessed overstatement, yet few (15.1%) had raised such an issue with a supervisor. Most (85.2%) respondents had few or no eLogbook entries validated. More than a quarter of respondents felt pressure to overstate their involvement in cases (28.6%) and the number recorded (28.1%). Almost a third (31.5%) felt the required case number for completion of training was not achievable. Female trainees were less likely to feel well supervised (p = 0.022) and to perceive targets for completion of training were achievable (p = 0.005). Thematic analysis identified four key themes to explain logbook misuse: Pressure to achieve training milestones; eLogbook functionality issues; training deficiencies and probity. CONCLUSIONS: Inaccurate operative recording was widely reported, primarily in response to perceived pressure to achieve targets for career progression. Operative logbooks may not be as accurate as intended. Consensus recommendations are made for improvement in the eLogbook and its use.


Assuntos
Avaliação Educacional/métodos , Registros , Estudantes de Medicina/psicologia , Cirurgiões/educação , Cirurgiões/psicologia , Adulto , Competência Clínica/normas , Consenso , Educação de Pós-Graduação em Medicina/normas , Avaliação Educacional/normas , Feminino , Humanos , Masculino , Inquéritos e Questionários , Reino Unido
3.
Int J Surg ; 67: 123-128, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30611897

RESUMO

The Association of Surgeons in Training (ASiT)'s motto is the pursuit of excellence in surgical training. The Association provides support to surgical trainees throughout the United Kingdom and Republic of Ireland. Originally founded in 1976, ASiT is independent of the National Health Service (NHS), Surgical Royal Colleges, and specialty associations. The 2018 Annual Conference in Edinburgh hosted over 800 delegates for a packed educational weekend. The conference theme was #nurturingexcellence and focused on helping trainees achieve their potential and improve surgical care. The importance of support for diversity in surgery was emphasised. An inclusive approach was fostered with a baby feeding room and a clear message that babies were welcome at the conference. Debates on the role of simulation in surgical training, sessions on reflective practice and the improving surgical training programme and a question and answer session with the presidents of the Royal colleges of surgeons made for lively and at times heated discussions. The weekend started with pre-conference courses covering a diverse range of topics including core laparoscopic, vascular, orthopaedics, neurosurgical skills, leadership, NOTSS and global surgery. Over 1000 abstract submissions were received and there were over 30 prize winning submissions. ASiT continues to grow and we look forward to an even larger and more successful international conference next year in Belfast 22nd-24th March, with an exciting parallel Hackathon to foster cross specialty cooperation to solve surgical problems.


Assuntos
Cirurgia Geral/educação , Cirurgiões/educação , Distinções e Prêmios , Congressos como Assunto , Humanos , Irlanda , Escócia , Sociedades Médicas , Reino Unido
4.
Int J Surg ; 67: 117-122, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30583014

RESUMO

BACKGROUND: Surgical trainees in the UK and Ireland undergo rigorous formative and summative assessments throughout each placement, and appraisal at an Annual Review of Competence Progression (ARCP). The ARCP evaluates performance during each training year and determines progression to the next year of training. It is critical that the ARCP is a robust and fair process. The Association of Surgeons in Training (ASiT) sought to evaluate surgical trainees' experiences of the ARCP process in order to identify areas for improvement. METHODS: An electronic survey was developed and distributed electronically to the trainee membership of ASiT in the UK and Republic of Ireland. A 57 point survey examined the specifics of one ARCP cycle as well as attitudes to the process in general. Quantitative analysis was performed, along with thematic analysis on the free-text comments. RESULTS: 600 trainees from all deaneries, grades and specialities participated. The survey demonstrated difficulties in preparing for ARCP: insufficient notice (24%), inadequate communication (22%) and lack of engagement of seniors (30-39%). 47% considered the process and standards inconsistent. 82% of trainees considered a face-to-face ARCP advantageous. Such a meeting provided a means of raising concerns regarding training posts (29%), bullying (18%) and patient safety (17%) that would not otherwise have been reported in writing. During qualitative analysis, the following themes emerged: The conflict between potential value and real experience; concerns regarding the quality of assessment and the need for improvement (in process, individual performance and surgical training.) CONCLUSION: This survey demonstrates that trainees appreciate the potential educational value of the ARCP process. However, there is a gap between this potential and trainees experience. Particular concerns include inconsistency, the timing of decision-making and the need to retain a face-to-face meeting. This feedback from trainees can be used to improve the assessment process in relation to procedural developments at the national level and engagement of supervisors and trainers locally. These changes will ensure that the ARCP becomes a higher quality assessment and more constructive for training in future.


Assuntos
Competência Clínica/normas , Educação de Pós-Graduação em Medicina/normas , Avaliação Educacional/normas , Estudantes de Medicina/psicologia , Cirurgiões/educação , Adulto , Estudos Transversais , Feminino , Humanos , Irlanda , Masculino , Percepção , Estudos Prospectivos , Cirurgiões/psicologia , Inquéritos e Questionários , Reino Unido
5.
Int J Surg ; 67: 107-112, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30668992

RESUMO

AIMS: Core surgical training (CST) programmes in the UK have seen a significant reduction in competition ratios over the past five years. This study aimed to determine motivating factors and perceived barriers to pursuing a career in surgery amongst junior doctors in training and medical students attending an annual conference. METHODS: A self-reported, electronic questionnaire was distributed to medical students, foundation year doctors, and doctors in postgraduate surgical training programmes (DIPST) who attended the Association of Surgeons in Training (ASiT) Conference in 2016. Respondents ranked factors attracting them to a career in surgery and factors that could improve perceptions of surgical careers. Chi-square test was used to test for differences between groups (a = 0.05, R Studio, V3.3.1). RESULTS: Of 394 respondents (response rate = 50.9%), 44.9% were medical students or foundation doctors ('Pre-CST') and 55.1% were DIPST ('Peri/post-CST'). Practical application of skills (97.4%), enjoyment of the theatre environment (95.4%) and positive experiences in surgical firms (84.7%) were primary driving factors towards a surgical career. Availability of private practice (32.2%), and sustainability of consultant jobs (49.0%) had less influence. For 'Pre-CST' respondents, role models (82.8% pre-CST v 74.9% peri-post CST, p < 0.05) and defined career progression (67.2% pre-CST v 47.0% peri-post CST, p < 0.001) were particularly important. 91% of all respondents agreed that a better balance of training and service within worked hours would improve perceptions of surgery. CONCLUSION: Addressing the motivating factors and perceived barriers to surgical careers will help bolster recruitment of the future surgical workforce.


Assuntos
Escolha da Profissão , Corpo Clínico Hospitalar/psicologia , Estudantes de Medicina/psicologia , Cirurgiões/educação , Feminino , Humanos , Irlanda , Masculino , Inquéritos e Questionários , Reino Unido
6.
Int J Surg ; 67: 94-100, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30995522

RESUMO

BACKGROUND: Surgical training is evolving, and simulation is becoming more important as a way to expedite the early learning curve and augment surgical techniques. With novel technology, and innovation, major changes are possible in how surgeons are trained. The integration of these concepts into the surgical curriculum may drive up educational standards and enhance patient safety. This survey sought to determine surgical trainees views on the current place of simulation in surgical training and explore their vision for the future. MATERIAL AND METHODS: This is a prospective, questionnaire-based cross-sectional study by *** and the ***, England. Surgical trainees were surveyed about their experiences of simulation during their training through an electronic questionnaire distributed in the UK and Republic of Ireland through mailing lists of RCS and ***. Quantitative and qualitative research methodology was used. RESULTS: Of 462 surveys submitted, a total of 323 were fully completed and included in the analysis. Core Surgical Trainees represented 28.4% of respondents. The vast majority of respondents (98.9%) considered that simulation training was important, however 55.0% felt it was delivered inadequately. 86.2% wanted greater access to simulation training: Less than half of respondents had access to simulation training at their current place of work or had simulation incorporated into their formal teaching programme (42.4% and 41.6% respectively). CONCLUSION: This study highlights the importance of simulation to trainees. Delivery and accessibility of simulation training varies widely. We highlight areas for improvement and best practice. In a culture of accountability, where patient safety is our highest priority, a "see one, do one, teach one" approach to training is no longer appropriate; instead we must utilise available simulation tools to augment learning.


Assuntos
Atitude do Pessoal de Saúde , Treinamento por Simulação , Cirurgiões/educação , Cirurgiões/psicologia , Adulto , Competência Clínica , Estudos Transversais , Currículo , Feminino , Humanos , Irlanda , Masculino , Estudos Prospectivos , Pesquisa Qualitativa , Inquéritos e Questionários , Reino Unido
7.
Int J Surg ; 67: 113-116, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30708061

RESUMO

INTRODUCTION: Surgical trainees are reporting barriers to training in gastrointestinal (GI) endoscopy. This snapshot survey aimed to gather data on variation in access to quality GI endoscopy training for Colorectal and Upper Gastrointestinal (GI) surgical trainees across the UK and Ireland. MATERIALS AND METHODS: An online 20-point survey was designed and distributed nationally to surgical trainee members of the Association of Surgeons in Training (ASiT), Dukes and The Roux Group (formerly Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland Trainees). The survey was designed in collaboration with The Roux Group for Upper GI trainees and the Dukes' Club for Colorectal trainees. RESULTS: 218 responses were received, most with a Colorectal or Upper GI sub-specialty interest (colorectal 56.0%; upper GI surgery 25.7%). Only 28.6% of trainees attended a dedicated training endoscopy list at least once a week with 28.1% not attending any at all. Less than half of trainees reported having endoscopy formally timetabled on rotas (36.9%). Most trainees (88.0%) encountered difficulties in gaining endoscopy training including lack of available lists (77.2%), conflicting operative commitments (59.4%), preferential allocation of lists to gastroenterology trainees (57.9%) and resistance from endoscopy departmental leads (38.6%). Regarding JAG accreditation, 77.1% respondents felt it should be mandatory prior to CCT with 80.3% believing this would lead to better access to dedicated endoscopy training equivalent to gastroenterology trainees. 93.1% trainees felt that attaining JAG accreditation by surgical trainees was important to patient care. DISCUSSION: This study demonstrates significant barriers in accessing GI endoscopy training for general surgical trainees which urgently needs to be improved. In order to meet JAG training requirements for surgical trainees, a multifaceted collaborative approach from surgical and gastroenterology training bodies, local JAG trainers and the General Surgery SAC and JCST is required. This is to ensure that endoscopy is promoted and a robust model of training is successfully designed and delivered to general surgery trainees.


Assuntos
Educação Médica/estatística & dados numéricos , Endoscopia Gastrointestinal/educação , Cirurgia Geral/educação , Cirurgiões/educação , Adulto , Competência Clínica , Feminino , Humanos , Irlanda , Masculino , Estudos Prospectivos , Inquéritos e Questionários , Reino Unido
8.
Ann R Coll Surg Engl ; 100(7): 580-583, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29909667

RESUMO

Introduction A recognised complication of carotid endarterectomy (CEA) is postoperative haematoma, which can threaten the airway. Previous studies have looked at medical methods of preventing this complication. This study aims to evaluate the impact of simple direct pressure postoperatively on the development of haematoma. Materials and methods From 2011 to 2016, 161 consecutive CEA were performed by a single surgeon or trainee under supervision. After 80 operations, the postoperative technique was altered, with additional pressure being applied by the surgeon to the skin incision from completion of suturing until each patient was awake in the recovery room. The rates of postoperative haematoma and other complications were compared between the pre- and post-intervention groups, as well as grade of surgeon, urgency of operation and antiplatelet/anticoagulant use. Results Post-carotid haematomas were eliminated in the post-intervention group (0/81); in the pre-intervention group 7/80 patients developed haematoma (P < 0.05). There were no significant differences in urgency of surgery, antiplatelet/anticoagulant use, grade of surgeon or other complications (stroke: 2/80 vs 0/81 P < 0.05), suggesting that this was not a learning curve effect. Discussion The results suggest that applying direct pressure helps to reduce oozing, provides time to monitor and identify additional bleeding and protects the wound from excessive strain that may be caused by coughing while the patient wakes up. We advise that the lead surgeon should apply such pressure to ensure precise and focal targeting, for maximum effect. Conclusion During recovery from CEA, focused and prolonged pressure by the operating surgeon is a highly effective method of reducing haematoma.


Assuntos
Endarterectomia das Carótidas/efeitos adversos , Hematoma/prevenção & controle , Hemostasia Cirúrgica/métodos , Hemorragia Pós-Operatória/prevenção & controle , Hematoma/epidemiologia , Hematoma/etiologia , Humanos , Pescoço/cirurgia , Hemorragia Pós-Operatória/epidemiologia , Hemorragia Pós-Operatória/etiologia , Período Pós-Operatório , Pressão , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
9.
Int J Surg ; 52: 349-354, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29428432

RESUMO

BACKGROUND: As front-line healthcare staff, doctors in surgical training occupy a unique organisational space rotating through hospitals and services in which they witness first hand both good and bad practice. This puts trainees in a clear position to identify and raise patient safety issues, and to contribute to discussions regarding quality and safety improvement. However, there are a number of real and perceived barriers to trainees doing so. These include concerns about the impact on training assessments and career progression, and uncertainty about the appropriate route. METHODS: Paper-based survey of delegates attending the Association of Surgeons in Training (ASiT) conference (response rate 73%; 479/652). RESULTS: 288 (60%) of trainees reported previous concerns over practices and behaviour of colleagues that might pose risks to patient care including concerns over poor performance (n = 243; 84%), bullying (n = 45; 16%), alcohol and drug abuse (n = 15; 5%) and mental health problems (n = 8; 3%). However, 53% (n = 153) did not escalate these concerns. 178 (37%) of trainees also reported concerns over hospital policies, protocols or systems that might pose a risk to patient care, with 46% (n = 82) not escalating such concerns. Respondents highlighted fear of personal vilification or reprisal (n = 224; 47%), fear of impact on career (n = 206; 43%) and a lack of confidence in the process (n = 170; 36%) as barriers to whistleblowing. More senior trainees were significantly more likely to raise concerns than more junior grades (p < 0.0001). CONCLUSION: These results highlight worrying issues around reporting concerns, with trainees often "silent witnesses" to poor performance in healthcare. Adverse events must provide opportunities for learning to improve future outcomes. Herein, ASiT proposes 14 recommendations to improve protection for trainees in raising patient safety concerns. These include the creation of a positive workplace culture, promoting the active involvement of trainees in quality improvement discussions, with clear mechanisms for trainees to raise concerns.


Assuntos
Segurança do Paciente/estatística & dados numéricos , Padrões de Prática Médica/estatística & dados numéricos , Qualidade da Assistência à Saúde/estatística & dados numéricos , Denúncia de Irregularidades/psicologia , Feminino , Humanos , Internato e Residência/estatística & dados numéricos , Masculino , Cirurgiões , Inquéritos e Questionários , Local de Trabalho
10.
World J Emerg Surg ; 10: 26, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26161133

RESUMO

The United Kingdom National Health Service treats both elective and emergency patients and seeks to provide high quality care, free at the point of delivery. Equal numbers of emergency and elective general surgical procedures are performed, yet surgical training prioritisation and organisation of NHS institutions is predicated upon elective care. The increasing ratio of emergency general surgery consultant posts compared to traditional sub-specialities has yet to be addressed. How should the capability gap be bridged to equip motivated, skilled surgeons of the future to deliver a high standard of emergency surgical care? The aim was to address both training requirements for the acquisition of necessary emergency general surgery skills, and the formation of job plans for trainee and consultant posts to meet the current and future requirements of the NHS. Twenty nine trainees and a consultant emergency general surgeon convened as a Working Group at The Association of Surgeons in Training Conference, 2015, to generate a united consensus statement to the training requirement and delivery of emergency general surgery provision by future general surgeons. Unscheduled general surgical care provision, emergency general surgery, trauma competence, training to meet NHS requirements, consultant job planning and future training challenges arose as key themes. Recommendations have been made from these themes in light of published evidence. Careful workforce planning, education, training and fellowship opportunities will provide well-trained enthusiastic individuals to meet public and societal need.

11.
N Z Med J ; 114(1126): 61-4, 2001 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-11280427

RESUMO

AIMS: Several clinical studies have proposed using d-dimer as an initial screening test to exclude thrombosis in cases of suspected (DVT). In published series, these assays have variable sensitivity, raising concerns that they may not be sufficiently robust for clinical practice. The aim of the study was to examine the sensitivity of two commercially available d-dimer assays and to assess their value and safety as initial screening tests in suspected DVT. METHODS: In this prospective study, blood samples were collected for d-dimer measurement (SimpliRED assay and IL test d-dimer) in all patients presenting to the emergency department over a twelve month period. All patients underwent compression ultrasound scanning as the primary diagnostic procedure. RESULTS: 235 patients were included in the study. 51(22.8%) had a DVT confirmed on ultrasound. The SimpliRED assay was positive in only 33 cases, with seventeen cases of confirmed DVT giving a negative result (six cases with proximal vein thrombosis). Assay sensitivity was 66%, with a negative predictive value of 88.9%. The IL test gave three false negatives (all below knee thromboses) giving assay sensitivity and negative predictive value of 94.1% and 96.8% respectively. CONCLUSIONS: The precise role of d-dimer testing in the diagnosis of venous thrombosis has yet to be established. From our results and a review of published series, we conclude that the SimpliRED assay is too insensitive to use as a reliable exclusion test in cases of suspected DVT, however, the more sensitive automated IL test d-dimer may have a role in the initial assessment. We propose that the IL d-dimer test is used in conjunction with a pre-test probability score to identify patients at low risk of DVT and recommend that this approach is tested in a clinical study before introduction into practice.


Assuntos
Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Tromboflebite/diagnóstico , Tempo de Coagulação do Sangue Total , Diagnóstico Diferencial , Humanos , Estudos Prospectivos , Sensibilidade e Especificidade , Tromboflebite/sangue , Ultrassonografia
12.
N Z Med J ; 105(929): 73-5, 1992 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-1532054

RESUMO

Ondansetron, a selective 5HT3 (serotonin) antagonist, was used in patients refractory to standard antiemetics. Seventy-five patients receiving chemotherapy without cisplatin were given ondansetron 4 mg IV and 4 mg orally immediately prior to chemotherapy, then 8 mg orally after six and 12 hours, followed by 8 mg orally eight hourly during days 2-5. Complete control of vomiting occurred in 52 patients (69%) on the first day and 45 patients (60%) on days 2-5. Sixty patients (80%) preferred ondansetron to their previous antiemetics. The efficacy of ondansetron was maintained over multiple chemotherapy cycles. Ondansetron was also given to 16 patients receiving cisplatin chemotherapy. They received 8 mg IV immediately prior to chemotherapy followed by an infusion of 1 mg/hr for 8 hr, with 8 mg orally at the end of the infusion and then 8 mg orally eight hourly during days 2-6. Some control of vomiting (less than = 5 vomits) was achieved in eight patients (50%) on the first day and in 14 patients (87%) on subsequent days. Eight patients (50%) preferred ondansetron to their previous antiemetics. Adverse events with ondansetron were frequent but mild, with constipation and headache being most common. Ondansetron is highly effective in patients refractory to standard antiemetics, especially after noncisplatin chemotherapy.


Assuntos
Antieméticos/uso terapêutico , Antineoplásicos/efeitos adversos , Imidazóis/uso terapêutico , Náusea/tratamento farmacológico , Vômito/tratamento farmacológico , Adulto , Idoso , Antieméticos/administração & dosagem , Antieméticos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Cisplatino/administração & dosagem , Cisplatino/efeitos adversos , Feminino , Humanos , Imidazóis/administração & dosagem , Imidazóis/efeitos adversos , Masculino , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Ondansetron , Vômito/induzido quimicamente
13.
Br J Rheumatol ; 28(1): 23-7, 1989 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-2917226

RESUMO

The levels of a range of components were measured by 1H nuclear magnetic resonance (1H NMR) in samples of synovial fluid taken from three groups of patients: 10 with osteoarthritis (OA), 18 with rheumatoid arthritis (RA), and 11 with traumatic effusions. A large number of low molecular weight species were measured simultaneously in addition to triglycerides and glycoproteins. Large variations were found between individuals in any one disease group, and there was no measurable correlation between disease state and levels of any low molecular weight component. However, patients with traumatic effusions had high levels of saturated triglycerides, while those with OA had low levels. The chain length of the triglycerides found in OA synovial fluid appears to be shorter than that for the other groups. In RA the composition of triglycerides appears normal, while the overall level is slightly above normal. In a separate study, serial samples of synovial fluid drawn from the knees of two arthritic patients were examined, and the concentrations of glycoprotein, triglycerides and creatinine were found to show a reasonable correlation with each other and with systemic measures of disease activity. These data suggest the potential of synovial fluid triglycerides and creatinine as inflammatory markers.


Assuntos
Artrite Reumatoide/metabolismo , Hidrogênio , Traumatismos do Joelho/metabolismo , Espectroscopia de Ressonância Magnética , Osteoartrite/metabolismo , Líquido Sinovial/análise , Exsudatos e Transudatos/análise , Glicoproteínas/análise , Humanos , Triglicerídeos/análise
14.
Biochem Biophys Res Commun ; 215(1): 377-85, 1995 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-7575616

RESUMO

Interleukin-1 (IL-1) and Oncostatin M (OM) induce a rapid and reproducible release of proteoglycan and collagen fragments from bovine nasal cartilage in culture. Over 90% of the total collagen was released by day 14 compared to a variable release with IL-1 alone. This release was accompanied by the appearance of collagenolytic activity in the medium that cleaved collagen specifically at the one quarter/three quarter position. Tissue inhibitor of metalloproteinases (TIMP-1) activity was low or absent in media from resorbing tissue. The breakdown of cartilage collagen could be prevented by the addition of BB94, a specific matrix metalloproteinase (MMP) inhibitor. These results suggest that T-cell/macrophage products within inflammed joints can interact with pro-inflammatory cytokines and lead to the rapid destruction of connective tissue collagen.


Assuntos
Cartilagem/metabolismo , Colágeno/metabolismo , Interleucina-1/farmacologia , Peptídeos/farmacologia , Animais , Cartilagem/efeitos dos fármacos , Bovinos , Glicoproteínas/metabolismo , Glicosaminoglicanos/metabolismo , Interleucina-1/administração & dosagem , Cinética , Metaloendopeptidases/antagonistas & inibidores , Nariz , Oncostatina M , Peptídeos/administração & dosagem , Fenilalanina/análogos & derivados , Fenilalanina/farmacologia , Inibidores de Proteases/farmacologia , Proteoglicanas/metabolismo , Tiofenos/farmacologia , Inibidores Teciduais de Metaloproteinases
15.
Aust N Z J Med ; 25(3): 224-9, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7487690

RESUMO

BACKGROUND: Adjuvant chemotherapy significantly improves survival of patients with non-metastatic osteosarcoma but most of the data come from trials conducted in major international cancer centres. AIM: To review the efficacy and toxicity of an adjuvant chemotherapy regimen used in two regional cancer centres in New Zealand. METHODS: Retrospective review of patients treated for non-metastatic high-grade osteosarcoma of the extremities. The regimen (POMA) consists of high-dose-methotrexate 8 g/m2 and vincristine 1.5 mg/m2 (maximum 2 mg) on days 1 and 8 followed by folinic acid then doxorubicin 50 mg/m2 and cisplatin 100 mg/m2 on day 15. This cycle was repeated every 35 days. Following amputation patients received six cycles while in selected patients two cycles were planned prior to limb salvage surgery followed by a further four cycles. Actuarial survival was calculated using the Kaplan-Meier method. RESULTS: Twenty patients were treated with POMA between 1986 and 1993. Amputation was performed in 16 patients and limb-salvage surgery in four. Sixteen patients (80%) remain alive with no evidence of disease at a median follow-up of 40 months. Thirteen patients (65%) have been continuously disease-free. Actuarial survival at five years is 70%. Seven patients relapsed, six in lungs, of whom four underwent pulmonary metastasectomy; three of these remain free of disease 31, 35 and 40 months later. There was no local relapse. The toxicity of POMA is significant but tolerable. CONCLUSION: The results obtained at two regional cancer centres in New Zealand using POMA compare favourably to those achieved in clinical trials performed at major international cancer centres.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Ósseas/tratamento farmacológico , Osteossarcoma/tratamento farmacológico , Adolescente , Adulto , Amputação Cirúrgica , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/cirurgia , Quimioterapia Adjuvante , Protocolos Clínicos , Feminino , Neoplasias Femorais/tratamento farmacológico , Neoplasias Femorais/cirurgia , Fíbula , Humanos , Úmero , Masculino , Nova Zelândia , Serviço Hospitalar de Oncologia , Osteossarcoma/mortalidade , Osteossarcoma/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida , Tíbia , Resultado do Tratamento
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