Detalhe da pesquisa
1.
Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.
Bioorg Med Chem Lett
; 74: 128942, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35973549
2.
Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis.
Int J Mol Sci
; 23(10)2022 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35628342
3.
The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.
J Cell Mol Med
; 23(3): 1759-1770, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536539
4.
Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.
Respir Res
; 16: 42, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25889951
5.
Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model.
Am J Physiol Renal Physiol
; 307(8): F908-16, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25143459
6.
PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.
J Pharmacol Exp Ther
; 347(2): 365-74, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23943052
7.
Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.
Nat Commun
; 13(1): 5555, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36138009
8.
Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction.
Pulm Pharmacol Ther
; 40: 30-8, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27453493
9.
Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse.
Sci Rep
; 11(1): 12437, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127702
10.
Semicarbazide-sensitive amine oxidase inhibition ameliorates albuminuria and glomerulosclerosis but does not improve tubulointerstitial fibrosis in diabetic nephropathy.
PLoS One
; 15(6): e0234617, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32555665
11.
Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice.
Int J Hematol
; 110(6): 699-708, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31637674
12.
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.
J Med Chem
; 62(21): 9874-9889, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31580073
13.
Author Correction: Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.
Nat Commun
; 14(1): 135, 2023 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36627321
14.
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.
Elife
; 72018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29966587
15.
Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation.
Br J Pharmacol
; 174(14): 2302-2317, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28437839
16.
The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells.
J Drug Target
; 25(4): 342-349, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27822974
17.
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.
Oncotarget
; 8(16): 26066-26078, 2017 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199967
18.
An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies.
Clin Transl Med
; 11(11): e572, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34841699
19.
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.
J Neurosci
; 22(13): 5572-80, 2002 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12097508
20.
Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor.
Br J Pharmacol
; 146(5): 702-11, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16100528