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J Cell Biochem ; 120(9): 15553-15560, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31056795

RESUMO

Breast cancer (BC) is a fatal malignancy, which has a high incidence and mortality across the world. Circular RNAs (circRNAs) have crucial roles in tumor initiation and progression. In this project, a newly found circRNA, circ_0103552 was explored. Quantitative real-time polymerase chain reaction was applied to measure its expression in the patients' tissue specimens and cells. In addition, Fisher's exact test, Kaplan-Meier curves and Cox regression model were conducted to discover the clinical significance of circ_0103552. Cell viability, clone-forming ability, apoptosis, and metastatic properties of BC cells were evaluated by gain/loss-of-function assays. Dual luciferase reporter assay was applied to illuminate its mechanisms. As data indicated, circ_0103552 was significantly elevated in BC tissue samples and cells. In addition, its expression correlates with clinical severity and dismal prognosis. Furthermore, circ_0103552 could facilitate cell growth, clone-forming ability, migration and invasion, and decrease apoptotic cells. For the mechanism exploration, circ_0103552 could directly sponge miR-1236 to execute oncogenic activities in BC cells. In summary, this study provides a novel circRNA in tumorigeneis and progression of BC and may help to develop effective therapeutic target for this devastating disease.


Assuntos
Neoplasias da Mama/genética , Carcinogênese/genética , MicroRNAs/genética , RNA Circular/genética , Apoptose/genética , Neoplasias da Mama/patologia , Movimento Celular/genética , Proliferação de Células/genética , Progressão da Doença , Intervalo Livre de Doença , Feminino , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Estimativa de Kaplan-Meier , Pessoa de Meia-Idade , Invasividade Neoplásica/genética , Invasividade Neoplásica/patologia , Prognóstico , Modelos de Riscos Proporcionais
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