RESUMO
The paper outlines a new mode of intravascular anabolic steroidal transport. The single intravenous administration of metandrostenolone aqueous solution to rats increases hypertrophy rate of MM. plantaris. It was shown that the action of a single dose (0.05 mg/kg) exceeded that of metandrostenolone oil solution in a dose of 5 mg/kg. The multiple reduction of doses of the anabolic drug and the high level of bioavailability were achieved. This effect was explained by the application of the specific transport agent.
Assuntos
Sangue/efeitos dos fármacos , Metandrostenolona/farmacologia , Músculos/efeitos dos fármacos , Músculos/patologia , Animais , Sangue/metabolismo , Relação Dose-Resposta a Droga , Hipertrofia/sangue , Hipertrofia/etiologia , Masculino , Metandrostenolona/administração & dosagem , Metandrostenolona/sangue , Ratos , Ratos Wistar , Solubilidade , Fatores de TempoRESUMO
A single intravenous administration of solubilized alpha-tocopherol acetate in a dose of 1 mg/kg to CBA x C57Bl x F1 male mice 3 and 24 hours before radiation was demonstrated to increase 30-day survival rates in the animals. Oily alpha-tocopherol acetate had the identical effects when the agent was intramuscularly given in a dose of 10 mg/kg. There was a rise in peripheral leukocyte counts 0.5 hour after solubilized alpha-tocopherol acetate administration. The antioxidative activity of the solubilized agent was 3.3 times as high as that the routine agent when attacking Tween 80. The higher radioprotective activity of solubilized alpha-tocopherol acetate is accounted for by its enhanced bioavailability, antioxidative activity and effects on the factors of nonspecific body's resistance.
Assuntos
Antioxidantes/administração & dosagem , Protetores contra Radiação/administração & dosagem , Vitamina E/análogos & derivados , alfa-Tocoferol/análogos & derivados , Animais , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Injeções Intravenosas , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Lesões Experimentais por Radiação/tratamento farmacológico , Lesões Experimentais por Radiação/mortalidade , Solubilidade , Fatores de Tempo , Tocoferóis , Vitamina E/administração & dosagemRESUMO
In rabbits with experimental hypocoagulation induced by phenylin, the use of a new dosage form of vitamin K1 for intravenous injections in does of 1 and 5 mg/kg led, in contrast to vicasol in a dose of 0.4 mg/kg, to an increase of the prothrombin index after 2 hours and to its complete normalization after 4 hours. Intravenous injection of vitamin K1 into intact animals did not entail any changes in the activated partial thromboplastin time, thrombin and prothrombin time, in the content of fibrinogen and products of its biotransformation, antithrombin III activity, and fibrinolytic activity or in the count of platelets and their aggregation capacity.
Assuntos
Coagulação Sanguínea/efeitos dos fármacos , Vitamina K 1/administração & dosagem , Animais , Transtornos da Coagulação Sanguínea/sangue , Transtornos da Coagulação Sanguínea/induzido quimicamente , Transtornos da Coagulação Sanguínea/tratamento farmacológico , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Fibrinólise/efeitos dos fármacos , Hemostáticos/administração & dosagem , Injeções Intramusculares , Injeções Intravenosas , Fenindiona , Tempo de Protrombina , Coelhos , Vitamina K/administração & dosagem , Vitamina K/análogos & derivados , Vitamina K 3RESUMO
A single intravenous injection of solubilized alpha-tocopherol acetate to Wistar male rats in doses of 25, 50 and 100 mg/kg noticeably increased the animals' working capacity. The stimulation effect appeared 18 hours after the injection and was observable for two weeks. Utilization of glucose reserves in bioenergy supply of muscle activity has been shown. The maintenance of the action for such a long time may be accounted for by high metabolic stability of solubilized alpha-tocopherol acetate.
Assuntos
Resistência Física/efeitos dos fármacos , Vitamina E/análogos & derivados , alfa-Tocoferol/análogos & derivados , Animais , Relação Dose-Resposta a Droga , Masculino , Esforço Físico/efeitos dos fármacos , Ratos , Ratos Wistar , Soluções , Natação , Tocoferóis , Vitamina E/administração & dosagem , Vitamina E/farmacologiaRESUMO
The rat experiments were made to compare the wound-healing action of solubilized (aqueous) alpha-tocopherol acetate (SATA) prepared by the original techniques and its official oil-based preparation. A course intravenous SATA (2 mg four times at an interval of 4 days) administration was found to stimulate epithelial regeneration and suppress the formation of connective tissue of uncomplicated skin wounds. By healing the complicated wounds, SATA potentiated the occurrence of an inflammatory reaction and slowed down regeneration, whereas its oily solution failed to produce this effect.