RESUMO
Different points of view on the need to conduct supportive acid-suppressive therapy gave rise to this study. The study is aimed at evaluating the influence of the individual supportive therapy based on the results of intragastric pH-monitoring on the incidence of duodenal ulcers. The study is based on a two-year observation of 90 patients with duodenal ulcers. After the ulcers had scarred and the patients had been discharged from hospital, all the patients were divided into three groups for undergoing a follow-up supportive acid-suppressive therapy. As a result, it was revealed that the individually selected supportive antisecretory therapy controlled by intragastric pH-monitoring within two years of observation made it possible to reduce considerably the incidence of duodenal ulcer recurrence in comparison with traditional preventive treatment.
Assuntos
Antiulcerosos/uso terapêutico , Úlcera Duodenal/tratamento farmacológico , Úlcera Duodenal/fisiopatologia , Duodeno/efeitos dos fármacos , Monitorização Fisiológica , Adolescente , Adulto , Duodeno/metabolismo , Feminino , Seguimentos , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Prevenção Secundária , Resultado do TratamentoRESUMO
High cost of medical care provided to the patients with duodenal ulcers requires improvement of treatment organization. This study is aimed at pharmacoeconomic evaluation of the efficacy of treating patients with duodenal ulcers. Two groups of patients were made up for the investigation. The first group was made up of patients who had undergone an individual antisecretory therapy based on intragastric pH-monitoring. The other group was made up of patients undergoing standard treatment without using intragastric pH-monitoring. Upon the comparison of the results in both groups, it was revealed that the "cost of illness" and "cost-efficacy" turned out to be lower in the group of patients where intragastric pH-monitoring for selecting individual antisecretory therapy was used.
Assuntos
Custos de Medicamentos , Úlcera Duodenal/tratamento farmacológico , Úlcera Duodenal/economia , Custos Hospitalares , Adulto , Antibacterianos/economia , Antibacterianos/uso terapêutico , Antiulcerosos/economia , Antiulcerosos/uso terapêutico , Úlcera Duodenal/microbiologia , Duodeno/metabolismo , Farmacoeconomia , Feminino , Helicobacter pylori , Humanos , Concentração de Íons de Hidrogênio , Masculino , Monitorização Fisiológica , Resultado do TratamentoRESUMO
Under study were complains related with digestion organs in practically healthy people who had not been subjected to abdominal operations. Selection of the healthy people was performed with the help of automatic screening. In 10-12% of the people who had no previous abdominal operations and who consulted with doctors for gastroenterological diseases there are many common disorders of functions of the digestion organs which should be taken into consideration in assessment of results of operative procedures.