RESUMO
BACKGROUND: The clinical significance of immunohistochemically detected isolated tumor cells (ITC) in lymph nodes of gastric cancer patients is controversial. This study examined the prognostic impact of ITC on patients with early-stage gastric cancer in two large volume centers in the United States and Japan. METHODS: Fifty-seven patients with T2N0M0 gastric carcinoma who underwent gastric resection between January 1987 and January 1997 at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York and 107 patients resected at National Cancer Center Hospital (NCCH) in Tokyo between January 1984 and December 1990 were studied. The sections were newly prepared from each lymph node for immunohistochemical staining for cytokeratin. Lymph nodes and original specimens from MSKCC were examined by pathologists in NCCH. The prognostic significance of the presence of ITC in lymph nodes was investigated in patients of both institutions. RESULTS: ITC were identified in 30 of 57 patients (52.6%) at MSKCC and in 38 of 107 patients (35.5%) at NCCH. In both institutions, there was no significant difference in the prognosis of the studied patients with or without ITC (P= .22, .86 respectively). CONCLUSIONS: The presence of ITC detected by immunohistochemistry in the regional lymph nodes did not affect the prognosis of American and Japanese patients with T2N0M0 gastric carcinoma who underwent gastrectomy with D2 lymph node dissection.
Assuntos
Adenocarcinoma/secundário , Linfonodos/patologia , Células Neoplásicas Circulantes/patologia , Neoplasias Gástricas/patologia , Adenocarcinoma/sangue , Adenocarcinoma/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Diferenciação Celular , Feminino , Seguimentos , Gastrectomia , Humanos , Técnicas Imunoenzimáticas , Japão , Queratinas/análise , Excisão de Linfonodo , Linfonodos/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Estadiamento de Neoplasias , Prognóstico , Fatores de Risco , Biópsia de Linfonodo Sentinela , Neoplasias Gástricas/sangue , Neoplasias Gástricas/cirurgia , Taxa de Sobrevida , Estados UnidosRESUMO
BACKGROUND: Morphologically similar soft-tissue sarcomas may behave in very different fashions, making it difficult to predict clinical outcomes and to properly design therapeutic interventions. In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical outcome. PURPOSE: We examined the potential clinical relevance of p53 overexpression in adults with soft-tissue sarcomas. We also studied the clinical implications of a high proliferation index. METHODS: A cohort of 174 adults with soft-tissue sarcomas were analyzed using anti-p53 and anti-Ki-67 antibodies and immunohistochemical assays on consecutive fresh frozen tissue samples. RESULTS: We observed a significant association between p53 nuclear overexpression and tumor grade (P = .001) and tumor size (P = .01). Patients displaying a p53-positive phenotype had significantly reduced survival (P = .02). Similarly, a significant difference was observed between high proliferation index and tumor grade (P < .001) and reduced patient survival (P = .03). A high Ki-67 proliferation index was detected in association with p53 nuclear overexpression. CONCLUSIONS: Overexpression of p53 protein and a high proliferation index strongly correlate with poor clinical outcome and reduced survival in patients having soft-tissue sarcomas.
Assuntos
Proteínas de Neoplasias/análise , Proteínas Nucleares/análise , Sarcoma/química , Proteína Supressora de Tumor p53/análise , Adulto , Anticorpos Monoclonais , Expressão Gênica , Humanos , Imuno-Histoquímica , Antígeno Ki-67 , Fenótipo , Valor Preditivo dos Testes , Prognóstico , Sarcoma/genética , Sarcoma/patologia , Análise de Sobrevida , Proteína Supressora de Tumor p53/genéticaRESUMO
PURPOSE AND METHODS: We identified patients with gastric cancer at high risk for recurrence before therapy using endoscopic ultrasonography (EUS). Neoadjuvant therapy using the fluorouracil, doxorubicin, and metrotrexate (FAMTX) regimen was given for three courses before planned laparotomy with the intention to perform curative resection. Postoperatively, intraperitoneal (IP) cisplatin and fluorouracil (FU) and intravenous (i.v.) FU were administered to patients undergoing resection. RESULTS: Fifty-six assessable patients were treated. Preoperative FAMTX therapy was tolerable, with the major toxicity being neutropenic fever. One treatment-related death was seen. Eighty-nine percent of patients underwent surgical exploration and 61% had potentially curative resections. There were two postoperative deaths. Comparison of pathologic tumor (pT) stage with EUS-predicted tumor stage showed apparent downstaging in 51% of patients. Postoperative IP chemotherapy was delivered to 75% of eligible patients. Toxicity was acceptable. There was no increase in operative morbidity or mortality compared with concurrent nonstudy patients undergoing a similar operative procedure and not receiving preoperative therapy. With a median follow-up time of 29 months, the median survival duration was 15.3 months. For patients who underwent potentially curative resections, the median survival duration was 31 months. Peritoneal failure was seen in 16% of patients. CONCLUSION: Chemotherapy with the FAMTX regimen is tolerable in patients with locally advanced gastric cancer, without an increase in operative morbidity or mortality. IP therapy can be successfully delivered to most resected patients. The intraabdominal failure pattern appears to be decreased compared with expected. This approach is an appropriate investigational arm to pursue in future studies.
Assuntos
Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adenocarcinoma/diagnóstico por imagem , Adenocarcinoma/mortalidade , Adenocarcinoma/cirurgia , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Cisplatino/administração & dosagem , Cisplatino/efeitos adversos , Terapia Combinada , Doxorrubicina/administração & dosagem , Doxorrubicina/efeitos adversos , Feminino , Fluoruracila/administração & dosagem , Fluoruracila/efeitos adversos , Humanos , Infusões Intravenosas , Infusões Parenterais , Masculino , Metotrexato/administração & dosagem , Metotrexato/efeitos adversos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Fatores de Risco , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/cirurgia , Taxa de Sobrevida , UltrassonografiaRESUMO
Adenocarcinomas of the esophagus and gastric cardia have increased in incidence over the past 10-15 years in Western countries. The cause for this increase in incidence is still unknown. Our study was designed to investigate potential risk factors for adenocarcinomas of the esophagus and gastric cardia and to compare the risk profiles of a group of patients with this cancer with those having distal stomach cancer. We studied 95 incident cases with the pathological diagnosis of adenocarcinomas of the esophagus and gastric cardia, 67 patients with adenocarcinomas of the distal stomach, and 132 cancerfree controls. Patients were seen at Memorial Sloan-Kettering Cancer Center from November 1, 1992 to November 1, 1994. Epidemiological data were collected by a modified National Cancer Institute Health Habits History Questionnaire. Risk factors were analyzed using Mantel-Haenszel methods and a logistic regression model. Hypertension was associated with a 2-fold increased risk of adenocarcinomas of esophagus and gastric cardia after controlling for age, sex, race, education, pack-years of smoking, alcohol use, body mass index, and total dietary intake of calories. Increased risk of adenocarcinomas of esophagus and gastric cardia was associated with age, male gender, and Caucasian race. Tobacco smoking was related to a modest risk of adenocarcinomas of esophagus and gastric cardia. In contrast, the risk of distal stomach cancer was associated with stomach ulcers and pack-years of cigarette smoking. Iron deficiency was significantly associated with increased risk of both adenocarcinomas of the esophagus and gastric cardia and adenocarcinomas of the distal stomach. No obvious associations were identified for occupational exposures, family history of cancer, and physical activities. This study suggests that medical conditions such as hypertension and iron deficiency may be related to the risk of adenocarcinomas of esophagus and gastric cardia and confirms the moderate risk associated with tobacco smoking. Our results indicated an etiological heterogeneity with respect to risk factors identified between adenocarcinomas of esophagus and gastric cardia and those of the distal stomach.
Assuntos
Adenocarcinoma/epidemiologia , Neoplasias Esofágicas/epidemiologia , Neoplasias Gástricas/epidemiologia , Adenocarcinoma/complicações , Adenocarcinoma/patologia , Adulto , Consumo de Bebidas Alcoólicas , Anemia Ferropriva/complicações , Esôfago de Barrett/complicações , Índice de Massa Corporal , Cárdia , Estudos de Casos e Controles , Neoplasias Esofágicas/complicações , Neoplasias Esofágicas/patologia , Feminino , Humanos , Hipertensão/complicações , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Fatores de Risco , Fumar , Fatores Socioeconômicos , Neoplasias Gástricas/complicações , Neoplasias Gástricas/patologiaRESUMO
As patients with gastric cancer are offered choices between surgical resection, investigational neoadjuvant chemotherapy, palliative chemotherapy, or symptomatic relief alone, the need for accurate preoperative staging becomes apparent. Laparoscopy has been suggested as an accurate staging modality in a variety of upper gastrointestinal malignancies. It allows for assessment of the stage of the primary tumor, identification of hepatic or regional nodal metastases, and the detection of small volume peritoneal disease unappreciated by other noninvasive staging modalities such as computerized tomography, magnetic resonance imaging or endoscopic ultrasound. This article reviews the current literature concerning laparoscopy and laparoscopic ultrasonography (LUS) in the staging of gastric cancer. The Memorial Hospital experience with 92 patients is described. In this group, metastatic disease unappreciated by conventional staging modalities was found in 31 cases. The preliminary experience with LUS suggests that its addition to standard laparoscopy increases the sensitivity and specificity of M1 screening as well as introducing T and N staging capabilities.
Assuntos
Laparoscopia , Neoplasias Gástricas/patologia , Ultrassonografia de Intervenção , Gastroscopia , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/secundário , Metástase Linfática/patologia , Imageamento por Ressonância Magnética , Estadiamento de Neoplasias , Neoplasias Peritoneais/patologia , Neoplasias Peritoneais/secundário , Sensibilidade e Especificidade , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/terapia , Tomografia Computadorizada por Raios XRESUMO
Gastric cancer has decreased significantly in incidence during the last half century in this country. Developments in surgery for gastric cancer have been slowed by the large percentage of patients presenting with advanced stages of the disease. In many ways, the combination and magnitude of these two characteristics pose a unique hurdle to progress in gastric cancer management in the United States. This review concentrates on current surgical issues, and offers a management approach that allows for continued progress in the pursuit of prolonging quality survival for patients with this disease.
Assuntos
Adenocarcinoma/cirurgia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/patologia , Terapia Combinada , Gastrectomia , Humanos , Incidência , Excisão de Linfonodo , Estadiamento de Neoplasias , Qualidade de Vida , Neoplasias Gástricas/patologia , Taxa de Sobrevida , Estados UnidosRESUMO
UNLABELLED: Primary solitary plasmacytoma and Ewing's sarcoma of the chest wall are relatively uncommon tumors, and data concerning treatment and results are sparse. To assess the results of therapy we reviewed our 40-year experience. METHODS: Records of 24 patients with solitary plasmacytoma and 62 with Ewing's sarcoma arising in the chest wall who were admitted to our institution from 1949 to 1989 were reviewed. RESULTS: In the group with plasmacytoma (n = 24), ages ranged from 35 to 75 years (median 59 years); male/female ratio was 2.4:1. The presenting complaint was pain or mass or both in 92% (22/24). Primary therapy was local only in 5 (resection in 3, radiotherapy in 2), chemotherapy in 16 (resection in 5, radiotherapy in 10, and chemotherapy alone in 1); 3 patients did not receive therapy. Multiple myeloma developed subsequently in 75% (18/24). Overall 5-year survival was 38% (median 56 months). Age, sex, site of primary tumor, and local therapy did not significantly impact on survival. Ages in the patients who had Ewing's sarcoma (n = 62) ranged from 2 to 39 years (median 16 years); male/female ratio was 1.6:1. Presenting complaint was pain or mass or both in 98% (61/62). Primary therapy was local in 17 (resection in 7, radiotherapy in 7, resection plus radiotherapy in 3) and chemotherapy in 45 (plus resection in 29, resection and radiotherapy in 10, and radiation therapy alone in 3). Overall 5-year survival was 48% (median 57 months). Age, sex, and site of primary tumor did not significantly impact on survival. Patients in whom distant metastases developed (n = 48) had a significantly decreased survival (5 year, 28%) compared with those who did not have metastases (n = 14; 5 year, 100%). CONCLUSION: Plasmacytoma of the chest wall, even if solitary at presentation, should be considered a systemic disease, and therapy should be directed as such. For Ewing's sarcoma, although resection or radiotherapy may offer local control, because of the prevalence of distant metastases (77%), systemic therapy should be considered an integral part of treatment.
Assuntos
Plasmocitoma , Sarcoma de Ewing , Neoplasias Torácicas , Análise Atuarial , Adolescente , Adulto , Idoso , Antineoplásicos/uso terapêutico , Biópsia , Criança , Pré-Escolar , Terapia Combinada , Feminino , Seguimentos , Hospitais Especializados , Humanos , Excisão de Linfonodo , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/complicações , Mieloma Múltiplo/epidemiologia , Recidiva Local de Neoplasia , Cidade de Nova Iorque/epidemiologia , Plasmocitoma/complicações , Plasmocitoma/epidemiologia , Plasmocitoma/terapia , Prevalência , Prognóstico , Radioterapia/normas , Fatores de Risco , Sarcoma de Ewing/complicações , Sarcoma de Ewing/epidemiologia , Sarcoma de Ewing/terapia , Taxa de Sobrevida , Neoplasias Torácicas/complicações , Neoplasias Torácicas/epidemiologia , Neoplasias Torácicas/terapia , Cirurgia Torácica/normasRESUMO
Primary splenic lymphoma accounts for 1% of lymphomas. The definition of primary splenic lymphoma is controversial and its clinical presentation is variable. This report describes a patient with primary non-Hodgkin's lymphoma of the spleen with transmural colonic invasion. This unique case represents the first reported instance of splenic lymphoma with histologically demonstrated invasion to the colonic mucosa. The clinical and pathologic features of this case and primary splenic lymphoma in general are reviewed.
Assuntos
Colo/patologia , Mucosa Intestinal/patologia , Linfoma/patologia , Neoplasias Esplênicas/patologia , Idoso , Humanos , Imageamento por Ressonância Magnética , Masculino , Invasividade NeoplásicaRESUMO
BACKGROUND: Although there is an increasing incidence of proximal gastric cancers in the United States, the appropriate extent of resection for proximal gastric cancer is not known. This study addresses whether the type of operation (total gastrectomy [TG] vs proximal gastrectomy [PG]) affects outcome for proximal gastric adenocarcinoma. METHODS: Review of the prospective gastric database at Memorial Sloan-Kettering Cancer Center from July 1985 to August 1995 identified 391 patients with proximal gastric cancer. Of those patients, 98 underwent curative TG or PG through an exclusively abdominal approach. Patients undergoing esophagogastrectomy (n = 293) were excluded from analysis. Data are expressed as medians and ranges. RESULTS: The length of hospital stay was the same for patients undergoing resection for PG (16.5 days [range 8 to 55]) and for TG (18 days [range 8 to 48]). In addition, hospital mortality rates for PG (6.0%) were similar to those for TG (3.0%). There was no significant difference in tumor differentiation and overall stage between the groups that underwent TG and those that underwent PG. There was no significant difference in time to recurrence between the two operative groups (PG, 15.7 months, versus TG, 18 months). In addition, there was no association between first site of recurrence and type of procedure. The overall 5-year survival rate for proximal gastric cancer was 43% (median survival 46 months), whereas the 5-year survival rate for TG was 41% (median survival 51 months; difference not significant). CONCLUSIONS: The extent of resection for proximal gastric cancer does not affect long-term outcome. TG and PG have similar overall survival rates and time and rate of recurrence, and both procedures can be accomplished safely.
Assuntos
Adenocarcinoma/cirurgia , Gastrectomia/métodos , Gastrectomia/estatística & dados numéricos , Neoplasias Gástricas/cirurgia , Procedimentos Desnecessários , Adenocarcinoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Bases de Dados como Assunto , Feminino , Mortalidade Hospitalar , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Estudos Prospectivos , Neoplasias Gástricas/patologia , Análise de SobrevidaRESUMO
Nutritional repletion in cancer reverses malnutrition and its associated immunodepression, but whether it benefits the host-tumor outcome has been variable. This study hypothesizes that such nutritional support will only favor that host generating a potent antitumor immune response. Murine neuroblastoma (NB) was characterized into immunizing C1300-NB and nonimmunizing TBJ-NB cell lines; and 100 6-week-old strain A mice were assigned on day -14 to isocaloric dietary groups (24% or 2.5% protein). At day 0, mice received either C1300-NB or TBJ-NB; on day 7 one half of the 2.5% group mice were repleted with 24% protein; on day 21, tumor weight/carcass weight (T/C) and mortality (M) were noted. Body weight increased 12.8% in the 24% group and fell 11.4% in the 2.5% group (p less than 0.01). The T/C ratios were smaller for immunogenic C1300-NB on 24% protein compared with 2.5% chow (0.0033 versus 0.0229; p less than 0.02). Repletion produced smaller tumors in the C1300-NB host; strikingly, repletion of TBJ-NB mice significantly increased tumor burden (T/C = 0.0186 versus 0.1657, p less than 0.01) and also increased animal mortality (M = 20% to 30%, p = NS). These data suggest that the influence of nutritional repletion on the tumor-bearing host varies specifically with the presence of an antitumor immune response.
Assuntos
Neuroblastoma/imunologia , Estado Nutricional , Animais , Anticorpos Antineoplásicos/biossíntese , Formação de Anticorpos , Peso Corporal , Proteínas Alimentares/administração & dosagem , Masculino , Camundongos , Camundongos Endogâmicos A , Neuroblastoma/patologiaRESUMO
Between 1982 and 1990, 69 adult patients were admitted to Memorial Sloan-Kettering Cancer Center with a diagnosis of angiosarcoma, lymphangiosarcoma, or malignant hemangiopericytoma. The existing literature regarding sarcomas focuses on individual histologic conditions or site-specific activity and includes pediatric patients, which makes estimates of survival difficult. We describe the clinical course of all vascular sarcomas, the survival without distant recurrence of patients with vascular sarcomas, and the overall survival of patients with vascular sarcomas. Using Cox's stepwise regression model, histologic characteristics of the tumors, tumor grade, tumor size, and other factors were assessed to determine their prognostic significance. Noncurative treatment and the presence of metastases were the only two factors influencing survival. Tumor grade approached significance. Disease recurrence was common among curatively treated patients (37% of such patients), and more than half of these recurrences involved distant sites. The survival of these patients depends on complete surgical resection and is independent of individual histologic characteristics of the tumor.
Assuntos
Hemangiopericitoma , Hemangiossarcoma , Linfangiossarcoma , Neoplasias de Tecidos Moles , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Hemangiopericitoma/mortalidade , Hemangiopericitoma/patologia , Hemangiopericitoma/terapia , Hemangiossarcoma/mortalidade , Hemangiossarcoma/patologia , Hemangiossarcoma/terapia , Humanos , Linfangiossarcoma/mortalidade , Linfangiossarcoma/patologia , Linfangiossarcoma/terapia , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia , Prognóstico , Análise de Regressão , Neoplasias de Tecidos Moles/mortalidade , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/terapia , Taxa de SobrevidaRESUMO
Primary bony and cartilaginous sarcomas of the chest wall are uncommon, and data concerning treatment and results are sparse. To assess the results of therapy, we reviewed our 40-year experience. Records of 38 patients with osteosarcoma and 88 with chondrosarcoma arising in chest wall admitted to Memorial Sloan-Kettering Cancer Center from 1949 to 1989 were reviewed. The 88 patients with chondrosarcoma ranged in age from 5 to 86 years (median age, 49 years); the male/female ratio was 1.3:1. Presenting complaint was mass, pain, or both in 93%. Primary therapy was resection (n = 84), radiation therapy (n = 3), or chemotherapy (n = 1). Overall 5-year survival was 64%. Significant adverse prognostic factors included metastases at initial presentation (n = 9), metastases at any time during the course of disease (n = 23), age greater than 50 years (n = 42), incomplete or no resection (n = 13), and local recurrence (n = 24). Sex, grade, and tumor size were not prognostic factors. The 38 patients with osteosarcoma ranged in age from 11 to 78 years (median age, 42 years); the male/female ratio was 1.5:1. Presenting complaint was mass, pain, or both in 95%. Primary therapy included resection (n = 31; alone in 13, with radiation therapy in 3, with chemotherapy in 15), radiation therapy (n = 3), radiation therapy and chemotherapy (n = 2), chemotherapy (n = 1), or no treatment (n = 1). Overall 5-year survival was 15%. Significant adverse prognostic factors included presence of synchronous metastases (n = 13) and metastases at any time during the course of disease (n = 26).(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Neoplasias Ósseas/terapia , Condrossarcoma/terapia , Osteossarcoma/terapia , Neoplasias Torácicas/terapia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/patologia , Criança , Pré-Escolar , Condrossarcoma/mortalidade , Condrossarcoma/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Osteossarcoma/mortalidade , Osteossarcoma/patologia , Estudos Retrospectivos , Taxa de Sobrevida , Neoplasias Torácicas/mortalidade , Neoplasias Torácicas/patologiaRESUMO
BACKGROUND: Variable reports exist about the early and long-term outcome after operative treatment for gastric carcinoma in the elderly. This study was designed to describe perioperative morbidity and factors influencing the length of hospitalization in patients older than 70 years of age in a tertiary care cancer center. METHODS: Patient information for a 10-year period, between July 1985 and July 1995, was obtained through a prospective database and chart review. Complications and length of stay were tabulated. Patient-, disease-, and treatment-related factors and their influence on outcome were compared by univariate and multivariate analysis using nonparametric product-limit models. RESULTS: Of 385 patients aged 71 years or older with gastric adenocarcinoma, 310 underwent resection. Postoperative complications occurred in 47.1 percent. Infectious complications predominated, most frequently involving intra-abdominal and pulmonary sites. Perioperative mortality was 7.1 percent. The median postoperative length of stay was 13 days (95 percent confidence interval 12 to 14 days; 25th percentile, 10 days; 75th percentile, 20 days). Factors independently predicting an increased duration of stay were presence of any complications, the type of resection, site of the primary carcinoma, and presence of postoperative infection. Complications added 30.4 percent of total patient days, or an average of 11.5 hospital days per patient with a complication. Although patients with postoperative complications had inferior overall and disease-specific survival, this was not an independent prognostic variable. Compared with patients younger than 70 years of age, elderly patients had a significantly increased hospital stay. CONCLUSIONS: The single most important factor leading to increased length of hospitalization is the occurrence of any complication. Although complicated by higher morbidity and mortality, the resection of gastric carcinoma in elderly patients can be performed relatively safely and leads to survival that is comparable to younger patients. The findings support careful patient selection and optimal preparation of elderly patients undergoing resection for gastric carcinoma.
Assuntos
Adenocarcinoma/cirurgia , Tempo de Internação/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/mortalidade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Institutos de Câncer/estatística & dados numéricos , Feminino , Gastrectomia/estatística & dados numéricos , Humanos , Masculino , Cidade de Nova Iorque/epidemiologia , Prognóstico , Modelos de Riscos Proporcionais , Estudos Prospectivos , Neoplasias Gástricas/mortalidade , Análise de Sobrevida , Fatores de TempoRESUMO
BACKGROUND: Wedge or other nonanatomic hepatic resections, performed in an attempt to spare functional parenchyma, often are not accomplished with clear resection margins and may be complicated by hemorrhage from the depth of the resection. STUDY DESIGN: The current study describes a technique of cryoassisted hepatic resection that allows for controlled resection with well-defined margins. The early experience in managing 16 tumors in 13 patients is reported. RESULTS: A cryoprobe is inserted into the tumor and freezing performed to a predetermined resection margin using ultrasound control. The ice ball, so formed, is then maintained and excised. The management of these 13 patients was associated with one intraoperative and two postoperative complications, including a death of a patient with cirrhosis who had infected ascites and died as a result of hepatic failure. CONCLUSIONS: Cryoassisted hepatic resection seems to be safe and allows resection with good tumor clearance and maximal preservation of functional parenchyma.
Assuntos
Criocirurgia , Hepatectomia/métodos , Neoplasias Hepáticas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Reconstruction of gastrointestinal tract continuity following total gastrectomy can be achieved using a variety of operations. Worldwide, Roux-en-Y esophago-jejunostomy with or without a pouch reservoir, is the most frequently performed operation after total gastrectomy. Others have advocated the preservation of the duodenal food passage, employing an interposed segment of bowel between the esophageal remnant and duodenum as a more physiologic operation. Several methods for either approach are described. In recent years, six randomized prospective clinical trials assessing various operations for gastrointestinal reconstruction have been reported. While there is a general consensus for the indications and patient selection criteria in order to proceed with total gastrectomy, a defined optimal procedure has not been clearly established. In the present work, these recent clinical studies addressing gastrointestinal reconstruction following total gastrectomy are reviewed and summarized.
Assuntos
Gastrectomia , Procedimentos de Cirurgia Plástica , Anastomose em-Y de Roux/métodos , Duodeno/cirurgia , Esôfago/cirurgia , Humanos , Jejuno/cirurgia , Estudos Prospectivos , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
The purpose of this study was to determine whether extended lymph node (D2) dissection is associated with a survival benefit for patients with histologically node-negative gastric cancer at a single institution in the United States. Review of the prospective gastric database at Memorial Sloan-Kettering Cancer Center from July 1985 to August 1995 identified 774 patients who had undergone curative gastric resection. Of these, 247 patients (32%) were identified with histologically negative lymph nodes by hematoxylin-eosin staining. Data are expressed as median (range). Overall survival was compared by log-rank test. The overall 5-year survival rate for the entire cohort was 79%. The extent of lymph node dissection did not predict survival over the entire cohort. However, when stratified for tumor (T) stage, D2 dissection offered a survival advantage for T3 tumors. The 5-year survival rate for patients with T3 tumors undergoing a D2 dissection (n = 15) was 54% compared to 39% for those undergoing a Dl dissection (n = 53, P <0. 05). D2 dissection is associated with improved survival in advanced T stage, node-negative gastric cancer. With adequate staging, results of gastric resection for adenocarcinoma in Western countries begin to approximate those seen in Japan. Excision of N2 lymph nodes may also remove microscopic metastatic disease, contributing to the survival benefit.
Assuntos
Excisão de Linfonodo/métodos , Neoplasias Gástricas/cirurgia , Adenocarcinoma/patologia , Adenocarcinoma/secundário , Adenocarcinoma/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Estudos de Coortes , Bases de Dados como Assunto , Feminino , Seguimentos , Gastrectomia , Humanos , Modelos Lineares , Linfonodos/patologia , Metástase Linfática/prevenção & controle , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estadiamento de Neoplasias , Modelos de Riscos Proporcionais , Estudos Prospectivos , Estudos Retrospectivos , Neoplasias Gástricas/patologia , Taxa de SobrevidaRESUMO
Gastric cancer patients in the United States have a poor prognosis with a collective 5-year survival rate of less than 15%. We identified a subset of actual 5-year survivors (long-term survivors) and analyzed clinicopathologic variables predictive of recurrence and survival beyond the 5-year mark. A review of our prospective database from July 1985 to February 1993 revealed 154 patients who were long-term survivors and 280 patients who died of disease prior to 5 years (short-term survivors) following curative resection (R0). Tumor (T) stage, nodal (N) status, tumor location, and median number of positive nodes were compared between the two groups. Univariate and multivariate analysis of disease-free and greater than 5-year disease-specific survival was performed within the long-term survivors. Among the long-term survivors, 29% were classified as "early gastric cancers" (T1NX). The median number of positive nodes (0 vs. 5; P <0.001) and percentage of lesions that were T1/T2 (60% vs. 19%; P <0.001), node negative (58% vs. 15%; P <0.001), or proximal (40% vs. 65%; P <0.001) was significantly different in long-term survivors vs. short-term survivors, respectively. Of the 154 five-year survivors, gastric cancer recurred in 23, and 13 patients (8%) died of the disease at a median of 84 months from the original diagnosis. On univariate and multivariate analysis of prognostic factors in the long-term survivors, only the Lauren histologic classification predicted disease-specific and disease-free survival with diffuse histologic types faring significantly less well. T stage and N status are powerful prognostic factors of outcome within the first 5 years after curative resection of gastric carcinoma. However, the Lauren histologic type emerges as the dominant predictor of outcome once a patient with gastric cancer has survived for 5 years or more.
Assuntos
Neoplasias Gástricas/mortalidade , Sobreviventes , Feminino , Gastrectomia , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Neoplasias Gástricas/cirurgia , Análise de SobrevidaRESUMO
To study the effect of residual microscopic resection line disease in gastric cancer, we compared 47 patients with positive margins to 572 patients who underwent R0 resections using a multivariate analysis of factors affecting outcome. Although the presence of positive margins was a significant and independent predictor of outcome for the entire group (N = 619), this factor lost significance in patients who had undergone D2 or D3 lymph node dissections (N = 466). Subset analysis within the D2/D3 group determined that this finding was limited mainly to those patients with.5 positive nodes (N = 189). The survival of patients who had =5 positive nodes (N = 277) was significantly worsened by a microscopically involved margin. Supporting this observation, intraoperative reexcision of microscopic disease based on frozen section analysis resulted in a significant improvement in overall survival in patients with =5 positive nodes but not in those with >5 positive nodes. We conclude that the significance of a positive microscopic margin in gastric cancer is dependent on the extent of disease. This factor is not predictive of outcome in patients who have undergone complete gross resection and have pathologically proved advanced nodal disease. Thus the goal in these cases should be an R0 resection when feasible but with the realization that the presence of >/=5 positive nodes (N2 disease according to the 1997 American Joint Committee on Cancer criteria) will mainly determine outcome and not microscopic residual cancer at the margin.
Assuntos
Gastrectomia/mortalidade , Recidiva Local de Neoplasia/mortalidade , Recidiva Local de Neoplasia/patologia , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/patologia , Feminino , Humanos , Excisão de Linfonodo/mortalidade , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estadiamento de Neoplasias , Cidade de Nova Iorque , Estudos Retrospectivos , Neoplasias Gástricas/cirurgia , Análise de SobrevidaRESUMO
Whether it is necessary to perform biliary drainage for obstructive jaundice before performing pancreaticoduodenectomy remains controversial. Our aim was to determine the impact of preoperative biliary drainage on intraoperative bile cultures and postoperative infectious morbidity and mortality following pancreaticoduodenectomy. We retrospectively analyzed 161 consecutive patients undergoing pancreaticoduodenectomy in whom intraoperative bile cultures were performed. Microorganisms were isolated from 58% of these intraoperative bile cultures, with 70% of them being polymicrobial. Postoperative morbidity was 47% and mortality was 5%. Postoperative infectious complications occurred in 29%, most commonly wound infection (14%) and intra-abdominal abscess (12%). Eighty-nine percent of patients with intra-abdominal abscess (P = 0.003) and 87% with wound infection (P = 0.003) had positive intraoperative bile cultures. Microorganisms in the bile were predictive of microorganisms in intraabdominal abscess (100%) and wound infection (69%). Multivariate analysis of preoperative and intraoperative variables demonstrated that preoperative biliary drainage was associated with positive intraoperative bile cultures (P <0.001), postoperative infectious complications (P = 0.022), intra-abdominal abscess (P = 0.061), wound infection (P = 0.045), and death (P = 0. 021). Preoperative biliary drainage increases the risk of positive intraoperative bile cultures, postoperative infectious morbidity, and death. Positive intraoperative bile cultures are associated with postoperative infectious complications and have similar microorganism profiles. These data suggest that preoperative biliary drainage should be avoided in candidates for pancreaticoduodenectomy.
Assuntos
Abscesso Abdominal/epidemiologia , Abscesso Abdominal/prevenção & controle , Bile/microbiologia , Drenagem , Pancreaticoduodenectomia/efeitos adversos , Infecção da Ferida Cirúrgica/epidemiologia , Infecção da Ferida Cirúrgica/prevenção & controle , Infecções Urinárias/epidemiologia , Infecções Urinárias/prevenção & controle , Abscesso Abdominal/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Cuidados Intraoperatórios , Masculino , Pessoa de Meia-Idade , Cuidados Pré-Operatórios , Estudos Retrospectivos , Infecção da Ferida Cirúrgica/etiologia , Infecções Urinárias/etiologiaRESUMO
The clinical records of patients identified by a prospective database as having undergone curative gastric resections for adenocarcinoma not involving the gastroesophageal junction were reviewed in order to examine transfusional practices and to determine if perioperative transfusion had an adverse effect on outcome. Between January 1985 and January 1992, 232 patients received such curative resections. The median follow-up for these patients was 19.0 months, whereas median survival for nonsurvivors was 12.3 months. Fifty-eight percent of the patients received transfusion of blood products. Fifty-four percent of these transfusions amounted to less than 2 units of blood products. By chi 2 analysis, advanced stage of disease (p = .03), advanced T-stage of primary tumor (p = .004), and total gastrectomy (p = .04) were associated with greater likelihood of transfusion. By univariate analysis, male sex (p = .004), total gastrectomy (p = .01), advanced stage of disease (p = .000006), high histologic grade of tumor (p = .03), and blood transfusion (p = .006) were predictors of poor outcome. By multivariate analysis using the proportional hazards model with stage, tumor grade, gender, extent of resection, and transfusion as covariates, blood transfusion was an independent predictor of poor outcome (p = .029, hazard 1.74). These results encourage prospective studies of transfusion on cancer recurrence and studies of alternatives to allogeneic blood transfusions in restoration of oxygen-carrying capacity during surgery in patients with gastric cancer.