Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
1.
Br J Cancer ; 109(4): 844-51, 2013 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-23868007

RESUMO

BACKGROUND: High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study aimed at their further characterisation. METHODS: Twenty-nine paediatric patients with centrally reviewed cerebellar HGG were identified from the HIT-GBM/HIT-HGG database. Clinical and epidemiological data were compared with those of 180 paediatric patients with cortical HGG. RESULTS: Patients with cerebellar tumours were younger (median age of 7.6 vs 11.7 years, P=0.028), but both groups did not differ significantly with regard to gender, tumour predisposing syndromes, secondary HGG, primary metastasis, tumour grading, extent of tumour resection, chemotherapy regimen, or radiotherapy. Except for an increased incidence of anaplastic pilocytic astrocytoma (APA) in the cerebellar subset (20.7% vs 3.3%; P<0.001), histological entities were similarly distributed in both groups. As expected, tumour grading had a prognostic relevance on survival. Compared with cortical HGG, overall survival in the cerebellar location was significantly worse (median overall survival: 0.92 ± 0.02 vs 2.03 ± 0.32 years; P=0.0064), and tumour location in the cerebellum had an independent poor prognostic significance as shown by Cox-regression analysis (P=0.019). CONCLUSION: High-grade glioma represents a group of tumours with an obviously site-specific heterogeneity associated with a worse survival in cerebellar location.


Assuntos
Neoplasias Cerebelares/diagnóstico , Glioma/diagnóstico , Adolescente , Distribuição por Idade , Astrocitoma/diagnóstico , Astrocitoma/epidemiologia , Astrocitoma/patologia , Estudos de Casos e Controles , Neoplasias Cerebelares/epidemiologia , Neoplasias Cerebelares/patologia , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Ganglioglioma/diagnóstico , Ganglioglioma/epidemiologia , Ganglioglioma/patologia , Glioblastoma/diagnóstico , Glioblastoma/epidemiologia , Glioblastoma/patologia , Glioma/epidemiologia , Glioma/patologia , Humanos , Lactente , Masculino , Gradação de Tumores , Oligodendroglioma/diagnóstico , Oligodendroglioma/epidemiologia , Oligodendroglioma/patologia , Prognóstico , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Distribuição por Sexo , Neoplasias Supratentoriais/diagnóstico , Neoplasias Supratentoriais/epidemiologia , Neoplasias Supratentoriais/patologia
3.
Radiologe ; 50(8): 706-10, 2010 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-20652214

RESUMO

The case of an adolescent female patient with acute lymphoblastic leukemia and stroke-like hemiparesis demonstrates a typical manifestation of methotrexate-induced acute encephalopathy. This rare entity occurs both in children and adults and can result from intrathecal as well as high dose intravenous administration of methotrexate. Diagnosis can confidently be made using cerebral MRI including diffusion-weighted imaging (DWI), so that patients can be informed about the favorable prognosis.


Assuntos
Antimetabólitos Antineoplásicos/efeitos adversos , Metotrexato/efeitos adversos , Síndromes Neurotóxicas/diagnóstico , Paresia/induzido quimicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamento farmacológico , Adolescente , Antimetabólitos Antineoplásicos/administração & dosagem , Encéfalo/efeitos dos fármacos , Encéfalo/patologia , Citarabina/administração & dosagem , Imagem de Difusão por Ressonância Magnética , Relação Dose-Resposta a Droga , Feminino , Humanos , Infusões Intravenosas , Injeções Espinhais , Metotrexato/administração & dosagem , Exame Neurológico/efeitos dos fármacos , Paresia/diagnóstico
4.
Orthopade ; 38(8): 752-4, 2009 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-19533085

RESUMO

Joint pain is one of the major symptoms in early leukemia. We report on a 16-year-old girl who presented with groin pain and an osteolytic bone lesion. Acute lymphoblastic leukemia was diagnosed, but the laboratory workup and radiologic imaging revealed atypical results. Particularly in early precursor B-cell acute lymphoblastic leukemia, comparable initial symptoms and signs have been reported in adolescents; therefore, we recommend performing a bone marrow aspiration early on in cases of suspected osteolytic bone lesions.


Assuntos
Hipercalcemia/complicações , Hipercalcemia/diagnóstico , Osteólise/complicações , Osteólise/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Adolescente , Crise Blástica/complicações , Crise Blástica/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos
5.
6.
Klin Padiatr ; 220(1): 29-31, 2008.
Artigo em Alemão | MEDLINE | ID: mdl-18293508

RESUMO

Both in Angelman-Syndrome and Graves' disease somatic and psychomotoric retardation, agitation and sleep disorder are major symptoms and signs. We report on the coincidence of both diseases in a 13 month old boy. Due to the overlapping pathology physicians should take special care on symptoms and signs of thyroid dysfunction in children with Angelman-Syndrome. In the case of coincidence a delayed diagnosis and treatment of hyperthyroidism could be avoided.


Assuntos
Síndrome de Angelman/epidemiologia , Doença de Graves/epidemiologia , Fatores Etários , Síndrome de Angelman/diagnóstico , Síndrome de Angelman/tratamento farmacológico , Anticonvulsivantes/administração & dosagem , Anticonvulsivantes/uso terapêutico , Antitireóideos/administração & dosagem , Antitireóideos/uso terapêutico , Comorbidade , Seguimentos , Doença de Graves/diagnóstico , Doença de Graves/tratamento farmacológico , Humanos , Lactente , Masculino , Metimazol/administração & dosagem , Metimazol/uso terapêutico , Tiroxina/administração & dosagem , Tiroxina/uso terapêutico , Fatores de Tempo , Ácido Valproico/administração & dosagem , Ácido Valproico/uso terapêutico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA