RESUMO
Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked an increase in total lipids, and specially in phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS + PI fractions indicates a specific effect of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphatidylinositol breakdown.
Assuntos
Regeneração Hepática/fisiologia , Fígado/efeitos dos fármacos , Fosfolipídeos/metabolismo , Somatostatina/farmacologia , Animais , Ciclo Celular/efeitos dos fármacos , Hepatectomia , Fígado/crescimento & desenvolvimento , Fígado/metabolismo , Extratos Hepáticos/metabolismo , Masculino , Proteínas/metabolismo , Ratos , Ratos EndogâmicosAssuntos
Regeneração Hepática , Linfócitos/fisiologia , Tecido Linfoide/fisiologia , Animais , Hormônio do Crescimento/farmacologia , Regeneração Hepática/efeitos dos fármacos , Linfócitos/imunologia , Masculino , Camundongos , Camundongos Endogâmicos CBA , Ratos , Ratos Endogâmicos , Somatostatina/farmacologiaRESUMO
This report describes a patient who presented with a non Q wave myocardial infarction and post-infarction angina. Angiography revealed that his only significant disease was a severe lesion in an acute marginal branch of the right coronary artery. Balloon angioplasty was performed successfully with subsequent stabilization and no recurrence of angina in a 9-month follow-up. This case raises the possibility that acute marginal disease may contribute to ischemic syndromes and warrants consideration for revascularization.