RESUMO
This comparative study of the influence of cytoflavin and cardioxipin on the parameters of 24-hour arterial pressure monitoring in 56 patients with chronic cerebral circulation insufficiency, arterial hypertension and hypercholesterolemia included 32 women and 24 men aged 42-72 years divided into 3 groups matchedfor the stage of diseases, age, sex, severity of AH, total cholesterol level, and antihypertensive therapy. Patients of group 1 were treated without cytoflavin and cardioxipin. Those in group 2 received daily i/v droplet infusion of 10 mg/kg cardioxipin (20-30 droplets/min). Patients of group 3 were given daily i/v droplet infusion of 10 ml cytoflavin in 200 ml 0.9% sodium chloride solution for 10 days. 24-hour arterial pressure monitoring was used to estimate the influence of the two drugs on systolic and diastolic pressure, its daily rhythm, AP variability and frequency of elevation. The study showed that both therapeutic modalities improved daily AP rhythm as manifested in a significant increase of the number of patients with the dipper rhythm and a decrease in the number of systolic/diastolic non-dipper patients. Moreover cytoflavin significantly decreased the number of systolic over-dippers compared with control group.
Assuntos
Anti-Hipertensivos/administração & dosagem , Pressão Arterial/efeitos dos fármacos , Monitorização Ambulatorial da Pressão Arterial/métodos , Transtornos Cerebrovasculares/tratamento farmacológico , Mononucleotídeo de Flavina/administração & dosagem , Hipercolesterolemia/tratamento farmacológico , Hipertensão/tratamento farmacológico , Inosina Difosfato/administração & dosagem , Niacinamida/administração & dosagem , Succinatos/administração & dosagem , Adulto , Idoso , Circulação Cerebrovascular/efeitos dos fármacos , Transtornos Cerebrovasculares/complicações , Transtornos Cerebrovasculares/fisiopatologia , Doença Crônica , Relação Dose-Resposta a Droga , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Hipercolesterolemia/complicações , Hipercolesterolemia/fisiopatologia , Hipertensão/complicações , Hipertensão/fisiopatologia , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Comparative tests on nonlinear rats of both sex with model violation of lipid metabolism have been performed in order to study the effects of cytoflavin (1.75 ml/kg or 175 mg/kg with respect to succinic acid) and cardioxipin (52.5 mg/kg) on lipid peroxidation and antioxidant protection indices in the blood. It is established that these preparations cause a decrease in the content of malonic dialdehyde (MDA) in erythrocytes that results in increased antioxidant activity and lipid reserves for peroxidation in the blood.
Assuntos
Antioxidantes/metabolismo , Dislipidemias/tratamento farmacológico , Eritrócitos/efeitos dos fármacos , Mononucleotídeo de Flavina/farmacologia , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Substâncias Protetoras/farmacologia , Piridonas/farmacologia , Succinatos/farmacologia , Animais , Animais não Endogâmicos , Catalase/sangue , Combinação de Medicamentos , Dislipidemias/sangue , Eritrócitos/química , Eritrócitos/metabolismo , Feminino , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Malondialdeído/antagonistas & inibidores , Malondialdeído/sangue , Ratos , Superóxido Dismutase/sangueRESUMO
OBJECTIVE: To compare the effects of cytoflavin and cardioxipin on the emotional status of rats with experimental disturbance of lipid metabolism using the uplifted cruciform labyrinth method. MATERIAL AND METHODS: The disturbance of lipid metabolism was induced by the introduction of exogenic cholesterol-in -oil emulsion in dosage 40 mg /kg of body mass during 20 days. Pharmacological treatment was performed in the 11th day. The drugs were injected intraperitoneally during 10 days: cytoflavin in dose 1,75 ml/ kg (175 mg/kg with succinic acid), cardioxipin in dose 52,5 mg/kg. RESULTS AND CONCLUSION: Cytoflavin and cardioxipin caused the positive changes in the parameters of emotional status of rats in conditions of experimental dyslipidemia.