Ultrasound-guided percutaneous cryoneurolysis for management of acute sternal fracture pain.

Background: Establishing adequate analgesia for rib and sternal fractures remains a challenge due to the prolonged nature of the associated pain. Historically, cryoneurolysis has demonstrated beneficial in treating chronic pain, and the recent development of hand-held devices has allowed its functionality to expand into the management of acute pain. Case: We present a polytrauma patient with sternal and multiple rib fractures that underwent ultrasound-guided intercostal cryoneurolysis at bedside, resulting in significant analgesia lasting several weeks and improving mobilization. This is the first report of the utilization of cryoneurolysis to treat acute sternal fracture pain. Conclusion: The most common sternal fracture pattern is transverse which only requires treatment of four intercostal nerves, making cryoneurolysis feasible in trauma centers. This portable, minimally invasive, and low risk technique has the added benefits of reducing opioid requirements, decreasing length of hospital stay, and improving mobility in polytrauma patients.

Arterial structure and function and its short- and long-term changes after bariatric surgery.

Subclinical arterial damage connected with endothelial dysfunction is a common denominator of cardiovascular complications in a variety of metabolic diseases, including obesity. The aims of the study was to assess functional vascular changes measured by flow-mediated dilatation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery, and to measure vascular structural alterations estimated by carotid intima-media complex thickness (IMT) in short- (10 days) and medium-term (6 months) time after bariatric surgery in patients with extreme obesity. Anthropometric, blood pressure (BP), FMD, NMD, IMT measurements, and laboratory assessment were performed on patients who met the eligibility criteria for bariatric surgery (age 18 - 60 years old, BMI ≥ 40.0 kg/m2 or with BMI 35.0 - 39.9 kg/m2 and co-morbidities), at baseline and during follow-up. The study population consisted of 71 patients: mean SD aged 45.6 (± 10.9) years; BMI = 47.7 (± 6.1) kg/m2; 45% of them were men). A significant reduction of systolic BP, glucose, HDL cholesterol, leptin, insulin and HOMA-IR were observed 10 days post intervention. A significant increase of FMD values was observed in the entire group 6 months after surgery (median (IQR) 6.2 (2.9 - 10.3) versus 8.5 (6.1 - 16.6), P < 0.05). Changes of NMD were insignificant. Carotid IMT diminished significantly after 6 months (median (IQR) 0.6 (0.5 - 0.7) versus 0.6 (0.5 - 0.6) mm, P < 0.05). A subgroup analysis revealed that FMD parameters had improved significantly after 6 months, mainly in men, hypertensives, and in the Roux-en Y bypass (RYGB) subgroup. In conclusion, endothelial function and subclinical atherosclerosis improved after bariatric surgery in patients with extreme obesity. A lack of changes of the dilatation independent of endothelial function may indicate the persistence of residual changes in the vascular bed.

Intima-media thickness of carotid artery and aortic pulse wave velocity as determinants of cerebral blood flow velocity.

The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima-media thickness (IMT), pulse wave velocity (PWV) and mean cerebral blood flow velocity (mCBFV) in the middle cerebral artery (MCA). In consecutive adult outpatients we recorded the brachial systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial blood pressure (MAP), PWV and IMT. mCBFV was assessed using Doppler ultrasound probe applied to the transtemporal window. The mean±s.d. age of 165 patients (50% women) was 56.7±11.8 years. Women and men differed significantly in SBP, PP, total cholesterol and mCBFV. Age (r=-0.44, P<0.001) and BMI (r=-0.25, P<0.01) were significantly and reversely related to mCBFV. Compared with healthy individuals, hypertensive (P<0.05) and diabetic (P<0.01) patients had lower mCBFV. IMT and PWV were related to mCBFV (IMT, r=-0.36; P<0.001, and PWV, r=-0.34; P<0.001). After adjustment for possible confounders, the relationship between mCBFV and PWV did not retain statistical significance (P=0.54). However, the relationship between mCBFV and IMT remained statistically significant (P=0.02). The association between lower CBFV and higher IMT may constitute a link between increased IMT and risk of cerebrovascular events.