RESUMO
A series of 1,5-diaminopentane derivatives, structurally related to nibentan, was synthesized and tested for antifibrillatory activity. Improved modifications of some known chemical syntheses were proposed. (+/-)-N-[5-(Diethylamino)-1-(4-nitrophenyl)pentyl]-benzamide hydrochloride, (+/-)-N-[5-(diethylamino)-1-(4-nitrophenyl)pentyl]-4-nitrobenzamide hydrochloride and (+/-)-N-[5-(diethylamino)-1-(4-hydroxyphenyl)pentyl]-4-nitrobenzamide hydrochloride were more potent than nibentan and possessed a longer duration of action (up to 5 h in comparison with 60-90 min for nibentan). The antifibrillatory activity of (+/-)-N-[5-(diethylamino)-1-(4-methoxyphenyl)pentyl]-4-nitrobenzamide hydrochloride was comparable to that of nibentan but exceeded the potency of D-sotalol and sematilide.
Assuntos
Antiarrítmicos/síntese química , Antiarrítmicos/farmacologia , Benzamidas/síntese química , Benzamidas/farmacologia , Diaminas/síntese química , Pentanos/síntese química , Animais , Gatos , Diaminas/farmacologia , Estimulação Elétrica , Ventrículos do Coração/efeitos dos fármacos , Ventrículos do Coração/fisiopatologia , Pentanos/farmacologia , Relação Estrutura-Atividade , Fibrilação Ventricular/fisiopatologia , Fibrilação Ventricular/prevenção & controle , Função VentricularAssuntos
Antiarrítmicos , Arritmias Cardíacas/tratamento farmacológico , Benzamidas , Benzamidas/uso terapêutico , Adolescente , Adulto , Idoso , Animais , Antiarrítmicos/administração & dosagem , Antiarrítmicos/química , Antiarrítmicos/farmacologia , Antiarrítmicos/uso terapêutico , Benzamidas/administração & dosagem , Benzamidas/química , Benzamidas/farmacologia , Ensaios Clínicos como Assunto , Cães , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fenetilaminas/uso terapêutico , Bloqueadores dos Canais de Potássio/uso terapêutico , Ramos Subendocárdicos/efeitos dos fármacos , Coelhos , Federação Russa , Sulfonamidas/uso terapêutico , Fatores de TempoRESUMO
Differential cross sections for Compton scattering from the deuteron were measured at MAX-Lab for incident photon energies of 55 and 66 MeV at nominal laboratory angles of 45 degrees, 125 degrees, and 135 degrees. Tagged photons were scattered from liquid deuterium and detected in three NaI spectrometers. By comparing the data with theoretical calculations in the framework of a one-boson-exchange potential model, the sum and the difference of the isospin-averaged nucleon polarizabilities, alpha(N)+beta(N)=17.4+/-3.7 and alpha(N)-beta(N)=6.4+/-2.4 (in units of 10(-4) fm(3)), have been determined. By combining the latter with the global-averaged value for alpha(p)-beta(p) and using the predictions of the Baldin sum rule for the sum of the nucleon polarizabilities, we have obtained values for the neutron electric and magnetic polarizabilities of alpha(n)=8.8+/-2.4(total)+/-3.0(model) and beta(n)=6.5-/+2.4(total)-/+3.0(model), respectively.
RESUMO
Measuring Compton scattered photons and recoil neutrons in coincidence, quasifree Compton scattering by the neutron has been investigated at MAMI (Mainz) at theta(lab)(gamma) = 136 degrees in an energy range from 200 to 400 MeV. From the data a polarizability difference of alpha(n)-beta(n) = 9.8+/-3.6(stat)+2.1-1.1(syst)+/-2.2(model) in units of 10(-4) fm(3) has been determined. In combination with the polarizability sum alpha(n)+beta(n) = 15.2+/-0.5 deduced from photoabsorption data, the first precise results for the neutron electric and magnetic polarizabilities, alpha(n) = 12.5+/-1.8(stat)+1.1-0.6(syst)+/-1.1(model) and beta(n) = 2.7-/+1.8(stat)+0.6-1.1(syst)-/+1.1(model), are obtained.