[Adult intramedullary gliomas]. / Tumeurs gliales intramédullaires de l'adulte : la série du rapport.

OBJECTIVES: Intramedullary gliomas are rare tumors accounting for less than 4% of all primary central nervous system tumors. The aims of this retrospective multicenter study were to assess their natural outcome as well as management. METHODS AND MATERIALS: We studied 332 patients from 1984 to 2011. Histopathological examination revealed 72% ependymomas (94% were low grade tumors), 24% astrocytomas (29% were high grade tumors), 2.4% mixed gliomas and 1.7% oligodendrogliomas. RESULTS: The mean age at diagnosis was 42.4 years for ependymomas, with male predominance, versus 39.6 years for astrocytomas. Pain was the most common initial presentation. In 20% of cases, astrocytomas were biopsied alone, but more than 80% of ependymomas had surgical resection. Radiotherapy and chemotherapy were reserved for malignant tumors, especially if they were ependymomas. The 5-year survival rate was 76.8% for astrocytomas and 94.5% for ependymomas. Histology, functional status prior to surgery, and tumor grade are among the prognostic factors. CONCLUSION: Our study showed that surgical treatment of gliomas is well codified, at least for ependymomas, but adjuvant treatment continues to play a marginal role in the management even in astrocytomas, which are infiltrative tumors.

Direct measurement of the wigner delay associated with the goos-Hanchen effect

It is shown experimentally that the nonspecular reflection of light on an interface induces a time delay, as predicted by Wigner's scattering theory. A differential femtosecond technique is used to directly isolate this delay, associated with the Goos-Hanchen spatial shift produced by a grating near a resonant Wood anomaly. A delay of 4.4 fs is observed between TE and TM pulses, in agreement with the expected Wigner delay obtained from phase shift dispersion measurements.

[Pneumomediastinum as a complication of recreational ecstasy use]. / Un pneumomédiastin, une complication exceptionnelle de la consommation d'ecstasy.

Ecstasy recreational use dramatically increased during the last decade in France. Multiples complications associated with ecstasy consumption have been reported. We describe an exceptional case of pneumomediastinum related to ecstasy recreational use. The patient was a 19-year old patient whose medical history was significant for asthma and was a moderate tobacco smoker. He reported regular ecstasy recreational use. He presented at the emergency unit for chest pain and cough, 48 hours after the ingestion of three tablets of ecstasy and the inhalation of three other tablets. Blood pressure was 90/60 mmHg, pulse rate was 120 per minute, respiratory rate was 32 per minute and pulse oximetry was 93%. Neck emphysema was noted. Chest radiograph and scanner diagnosed pneumomédiastinum. Outcome was favorable with symptomatic treatment and the patient was discharged home eight days later. Pneumomediastinum is an exceptional complication after ecstasy recreational use. Physician should be aware of the risk of such event.

Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes.

Devic's neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.

Time-resolved torsional relaxation of spider draglines by an optical technique.

The sensitivity of the torsional pendulum demonstrates the self-shape-memory effect in different types of spider draglines. Here we report the time-resolved noncovalent bonds recovery in the protein structure. The torsional dynamics of such multilevel structure governed by reversible interactions are described in the frame of a nested model. Measurement of three different relaxation times confirms the existence of three energy storage levels in such two protein spidroin systems. Torsion opens the way to further investigations towards unraveling the tiny torque effects in biological molecules.

A dipole interaction model for magnetochiral birefringence.

We have developed a classical model to investigate the magnetochiral birefringence of an isotropic chiral medium submitted to a longitudinal magnetic field. This model, which is an extension of the atom dipole interaction model, yields direct calculations from the polarizabilities and positions of the atoms of the considered molecules. The numerical values obtained for the magnetochiral birefringence, as well as for the optical activity and Faraday rotation, are supported by the previously published experimental results on limonene, proline, and tartaric acid.

Frequency fluctuations of stabilized lasers with anisotropic feedbacks.

A random phase method is proposed to determine the perturbation of the Allan variance of frequency stabilized lasers submitted to optical feedbacks. The role of different feedbacks is quantitatively described for both one-oscillating-eigenstate stabilized lasers and two-oscillating-eigenstate stabilized lasers. The importance of the feedback polarization is isolated in each system. In both cases, the experimental measurements of the Allan variance and of the peak-to-peak frequency variations due to a periodic modulation of the feedback phase are found to be in agreement with the theoretical predictions.

Tunable optical microwave source using spatially resolved laser eigenstates.

A two-propagation-axis solid-state laser is shown to provide a widely tunable optical microwave source. The spatial separation of the laser eigenstates is shown to enable an étalon to act as a coarse tuner, forcing oscillation in any nonadjacent cavity modes. The frequency difference between opposite helicoidal eigenstates operating in nonadjacent cavity modes can then be tuned continuously. The beat note from such a solid-state laser is shown to vary from dc to 26 GHz, i.e., 30 times the laser free-spectral range, and is limited only by the free-spectral range of the étalon.

Temporal behavior of an unstable optical cavity.

The relaxation of a geometrically unstable Fabry-Perot cavity is theoretically and experimentally investigated. It is observed that the usual sum of the exponential decays of the intensities in the different transverse modes of the cavity is replaced by a more complex behavior. In particular, light couplings into the fundamental mode of the cavity with initial wave excitation factors larger than unity, i.e., larger than in the case of mode-matched injection, are directly observed. The influence of the cavity Fresnel number and of transverse mode crossings and anticrossings on these cavity decays is isolated.

Existence of two coupling constants in microchip lasers.

We implemented two different experimental setups to probe directly the nonlinear coupling between modes in microchip lasers. We show that, remarkably, the results can be interpreted by use of Lamb's coupling constant. In an Er, Yb:glass microchip laser, we measured C(12) = 0.80 between longitudinal modes and C(xy) = 0.95 between orthogonally linearly polarized eigenstates. The high values obtained give some physical insight into the single-frequency operation of such lasers.

Rabi-Lorentzian profile of an atomic resonance obtained with Gaussian beams.

We demonstrate that the interaction between atoms and a Gaussian beam changes the Lorentzian resonance into a so-called Rabi-Lorentzian resonance profile. The existence of such profiles is experimentally evidenced in a dark resonance situation for metastable (4) He, in the absence of any external perturbation. A topological mechanism is shown theoretically to account for the measured profiles. We observe a 3% systematic residual with respect to a pure Lorentzian profile, which could play a role in the search of high precision in the measurement of fundamental constants.