RESUMO
Central venous catheters are used increasingly in oncology patients. Spontaneous fracture and embolization of a catheter is a rare complication. This report illustrates such a case, in which the fragment was retrieved percutaneously. Impending line fracture may be detected by the 'pinch-off sign' on a chest radiograph. Prevention may be possible by inserting the catheter more laterally.
Assuntos
Cateterismo Venoso Central/instrumentação , Cateteres de Demora/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma/tratamento farmacológico , Carcinoma/secundário , Cateterismo Venoso Central/efeitos adversos , Cateterismo Periférico , Falha de Equipamento , Feminino , Veia Femoral , Migração de Corpo Estranho/etiologia , Migração de Corpo Estranho/terapia , Humanos , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/secundário , Pessoa de Meia-Idade , Artéria Pulmonar , Veia Subclávia , Propriedades de Superfície , Tromboembolia/etiologiaRESUMO
After the publication of the 10-year survival data from Milan on the adjuvant use of the block sequential regimen consisting of four cycles of adriamycin followed by eight cycles of intravenous CMF, many centres adopted this as standard of care for high risk, multiple node-positive breast cancer. For this reason it was identified as the standard arm for the Anglo-Celtic adjuvant high-dose chemotherapy trial. This study reports on the experience of this regimen in 329 women with early breast cancer involving at least four axillary nodes, who were treated outside any adjuvant chemotherapy trial. At a median follow-up of 3 years, the overall 5-year disease-free survival is 61%, and the overall survival is 70%. These data confirm the efficacy of this regimen in non-trial patients, and, for the same high risk subgroup, indicate that this approach offers an outcome at least as good as that seen in the CALGB 9344 AC-Taxol arm, and the NCIC days 1 and 8 CEF.