RESUMO
Maytenus ilicifolia (Celastraceae), popularly known as espinheira-santa, is a native plant from the Atlantic forest and is commonly used in popular medicine to treat inflammation and as an abortifacient. To evaluate the effects of M. ilicifolia on pregnant rats during the organogenic period (T1) or throughout the gestational period (T2), an extract obtained using an acetone-water mixture at a 70:30 ratio was administered via gavage at a dose of 15.11 mg·kg(-1)·day(-1) over 2 treatment periods (T1 and T2). No clinical signs of maternal toxicity were observed. Term fetuses did not present malformations or anomalies as the number of implantations, reabsorptions, live, and dead fetuses were similar to the control group. In conclusion, M. ilicifolia hydroacetonic extract is non-toxic to pregnant rats and appears to not interfere with the progress of embryo-fetal development.
Assuntos
Desenvolvimento Embrionário/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Reprodução/efeitos dos fármacos , Animais , Embrião de Mamíferos/efeitos dos fármacos , Feminino , Maytenus/química , Extratos Vegetais/química , Gravidez , Ratos , Ratos WistarRESUMO
We studied the continuous phase transition between the active and the absorbing state of the Ziff-Gulari-Barshad (ZGB) model. Through Monte Carlo simulations we determined all the moments of the order parameter up to fourth order and their ratios at the critical point. We show that the ratios we found are in agreement with those of the contact and pair contact processes in two dimensions, which give support to the idea that the ZGB model is in the directed percolation universality class in (2+1) dimensions.