Modality Changes in Vigilance Displays: Further Evidence of Supramodal Resource Depletion in Vigilance.

OBJECTIVE: This study was designed to evaluate the effects of a modality change on vigilance performance to determine whether depletion of modality-specific resources contributes to the vigilance decrement. BACKGROUND: Resource theory accounts for the vigilance decrement by arguing that the demands of vigilance deplete limited information processing resources. Research indicates that both supramodal and modality-specific resources are involved in vigilance, but it is unclear whether the vigilance decrement is due to depletion of supramodal resources, modality-specific resources, or both. If depletion of modality-specific resources contributes to the decrement, changing the modality of a vigilance display should improve vigilance performance after a decrement. METHOD: Participants completed a 50-min vigilance task beginning in either the visual modality or the auditory modality. After 40-min, half of the participants experienced a sudden transition to the other modality; the remaining participants did not experience a modality change. RESULTS: Performance declined over time and was generally superior in the auditory modality. Changing modality from visual to auditory increased correct detections, whereas changing from auditory to visual decreased correct detections. Both types of modality change were associated with an increase in false alarms, and neither had an effect on workload or stress. CONCLUSION: Supramodal resource depletion, rather than modality-specific resource depletion, is the most likely explanation for the vigilance decrement that can be derived from resource theory. APPLICATION: Modality changes are not likely to counteract the vigilance decrement and may actually increase false alarm errors. Countermeasure development should involve identification of depleted supramodal resources.

Is Physiobehavioral Monitoring Nonintrusive? An Examination of Transcranial Doppler Sonography in a Vigilance Task.

OBJECTIVE: The current study was designed to determine whether continuous, physiobehavioral monitoring via transcranial Doppler sonography (TCD) has negative effects on human performance or user state in a vigilance task. BACKGROUND: Physiobehavioral measures have been identified as a promising method of user state assessment, in part because they are thought to be relatively nonintrusive. The notion that physiobehavioral measures are nonintrusive should not be taken for granted and needs to be tested empirically. It is possible that, even though physiobehavioral measures do not require input from a user, they may still hinder performance by causing discomfort, distraction, or interfering with physical activities required for task performance. METHOD: The current study employed TCD, a common method of monitoring user vigilance. Participants completed a 40-min vigilance task. During the task, 50% wore TCD apparatus, while 50% did not. Intrusiveness was measured in terms of vigilance performance as well as workload, stress, and simulator sickness. RESULTS: Analyses revealed results that mirrored prototypical vigilance findings: performance declined over time, workload was high, distress and reported simulator sickness symptomology increased during the task, while engagement decreased. The presence or absence of TCD monitoring had no direct or interactive effects on performance or user state. CONCLUSION: TCD monitoring of user vigilance appears to be nonintrusive. APPLICATION: Findings support the recommendation that TCD should be used in research and operational settings where user vigilance is of paramount importance. More broadly, when developing and fielding physiobehavioral state measurement systems, intrusiveness should be considered and evaluated.

Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain.

Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure has also been shown to compromise the structural integrity of mature neurons throughout the brain, an effect believed to be at least in part responsible for the deterioration of cognitive health. Past work has shown that cranially transplanted human neural stem cells (hNSCs) or their extracellular vesicles (EVs) afforded long-term beneficial effects on many of these cognitive decrements. To provide additional insight into the potential neuroprotective mechanisms of cell-based regenerative strategies, we have analyzed hippocampal neurons for changes in structural integrity and synaptic remodeling after unilateral and bilateral transplantation of hNSCs or EVs derived from those same cells. Interestingly, hNSCs and EVs similarly afforded protection to host neurons, ameliorating the impact of irradiation on dendritic complexity and spine density for neurons present in both the ipsilateral and contralateral hippocampi 1 month following irradiation and transplantation. These morphometric improvements were accompanied by increased levels of glial cell-derived growth factor and significant attenuation of radiation-induced increases in postsynaptic density protein 95 and activated microglia were found ipsi- and contra-lateral to the transplantation sites of the irradiated hippocampus treated with hNSCs or hNSC-derived EVs. These findings document potent far-reaching neuroprotective effects mediated by grafted stem cells or EVs adjacent and distal to the site of transplantation and support their potential as therapeutic agents to counteract the adverse effects of cranial irradiation.