RESUMO
The interaction between blood platelets and the walls of blood vessels is changed after burn injury to rats and guinea-pigs. Treatment of burned experimental animals with heparin, nicotinic acid, thrental, phytin, glutamic acid and alpha-tocopherol inhibited the increase in platelet-vascular wall interaction, improved the microcirculation in mesenteric vessels and increased the endurance of the animals to physical stress.
Assuntos
Plaquetas/fisiopatologia , Vasos Sanguíneos/fisiopatologia , Queimaduras/fisiopatologia , Animais , Vasos Sanguíneos/patologia , Queimaduras/patologia , Feminino , Cobaias , Masculino , Malondialdeído , Veias Mesentéricas/patologia , Agregação Plaquetária , Ratos , Ratos Endogâmicos , Fatores de TempoRESUMO
The administration of drugs influencing disordered haemostasis (heparin, nicotinic acid, thrental, phytin and alpha-tocopherol) to patients with burn injuries caused a 43 per cent shortening of the period of treatment. Necrotic eschar separated 7-9 days earlier and the periods necessary to prepare the burn wounds for surgical repair were shortened by 5 days. The success of skin grafting was enhanced with an increased percentage of attachment of the grafts. Necrotic changes of the mucosa of the gastrointestinal tract were found in 35 per cent of patients treated with the drugs as compared with 60 per cent of patients treated by the usual methods.