RESUMO
In recent years Carbohydrate Deficient Transferrin has been introduced as a new marker to diagnose alcoholism. It has proved to have superior qualities compared to other markers like Gamma-Glutamyl-Transferase (GGT). With reference to current research the authors critically discuss the sensitivity and the specificity of CDT. The use of CDT when verifying a claim of abstinence is thought to be very low. In addition, CDT is of only limited use in the detection of above average alcohol consumption. Other questions regarding the performance of CDT require further scientific research. Therefore the authors argue that, at present, it is too early to use CDT in the context of medico-psychological examinations of drink drivers.
Assuntos
Alcoolismo/diagnóstico , Condução de Veículo/legislação & jurisprudência , Prova Pericial/legislação & jurisprudência , Transferrina/análogos & derivados , Alcoolismo/sangue , Alcoolismo/reabilitação , Biomarcadores , Humanos , Valor Preditivo dos Testes , Garantia da Qualidade dos Cuidados de Saúde , Valores de Referência , Transferrina/análiseAssuntos
Aminoácidos/sangue , Fenilalanina/sangue , Fenilcetonúrias/metabolismo , RNA/urina , Adolescente , Adulto , Criança , Pré-Escolar , Humanos , Lactente , Recém-NascidoRESUMO
We investigated the urinary excretion of ribonucleosides and an unidentified substance in 345 healthy probands from the age of a few weeks to 40 years. The concentration of ribonucleosides, related to the corresponding concentration of creatinine, decreases until nearly 20 years and remains constant between 20 and 40 years. The polynomial functions describing this dependency are presented. The biological significance of our findings is briefly discussed.