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Am J Transplant ; 12 Suppl 4: S43-8, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22642508

RESUMO

Outcomes of intestinal transplants (ITx; n = 977) for pediatric patients are examined using the United Network for Organ Sharing data from 1987 to 2009. Recipients were divided into four age groups: (1) <2 years of age (n = 569), (2) 2-6 years (n = 219), (3) 6-12 years (n = 121) and (4) 12-18 years (n = 68). Of 977 ITx, 287 (29.4%) were isolated ITx and 690 (70.6%) were liver and ITx (L-ITx). Patient survival for isolated ITx at 1, 3 and 5 years, 85.3%, 71.3% and 65.0%, respectively, was significantly better than L-ITx, 68.4%, 57.0% and 51.4%, respectively, (p = 0.0001); this was true for all age groups, except for patients <2 years of age. The difference in graft survival between isolated ITx and L-ITx was significant at 1 and 3 years (Wilcoxon test, p = 0.0012). After attrition analysis of graft survival of patients who survived past first year, 3 and 5 years, graft survival for L-ITx patient was significantly better than those for isolated ITx. Isolated ITx should be considered early before the onset of liver disease in children >2 with intestinal failure but is not advantageous in patients <2 years.


Assuntos
Fatores Etários , Rejeição de Enxerto/epidemiologia , Intestinos/transplante , Transplante de Órgãos/estatística & dados numéricos , Transplante , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Masculino , Transplante de Órgãos/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Resultado do Tratamento , Vísceras/transplante
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