1.
Bioorg Med Chem Lett
; 30(24): 127637, 2020 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33132114
RESUMO
We found that sulfisomidine, a sulfonamide antibiotic, potently binds to the Piwi/Argonaute/Zwille (PAZ) domain of human Argonaute protein 2 and inhibits RNA interference (RNAi). To elucidate the effect on RNAi of strong affinity of the 3'-ends in small interfering RNA (siRNA) to the PAZ domain, chemically modified siRNAs bearing sulfisomidine at the 3'-end were synthesized.