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Angiogenesis ; 25(2): 159-179, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34524600

RESUMO

Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here that overexpression of bioactive chemerin in mice results in a reduction of the density of the retinal vascular network during its development and in adults. Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning. This phenotype was reversed to normal in CMKLR1-deficient mice, demonstrating the role of this receptor. Chemerin inhibited also neoangiogenesis in a model of pathological proliferative retinopathy, and in response to hind-limb ischemia. Mechanistically, PTEN and FOXO1 antagonists could almost completely restore the density of the retinal vasculature, suggesting the involvement of the PI3-kinase/AKT pathway in the chemerin-induced vessel regression process.


Assuntos
Quimiocinas , Peptídeos e Proteínas de Sinalização Intercelular , Animais , Apoptose , Quimiocinas/metabolismo , Hipóxia , Peptídeos e Proteínas de Sinalização Intercelular/genética , Camundongos
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