1.
Chem Biodivers
; 19(2): e202100602, 2022 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34927353
RESUMO
Here six novel imidazolinone derivatives have been synthesized and the compound 4b containing 5-para-methoxy-phenylidene and 2-thioalkylation terminal substitution with 3'-cyano-2',6'-dimethylphenyl showed the best anti-HCV activity and the lowest cytotoxicity. Selectivity index (SI=CC50 /IC50 ) for the 4b was determined as 36, indicating that compound 4b was highly selective towards HCV.