Pesquisa | BVS Educação Profissional em Saúde

1.

Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition.

Burt, Trevor D; McCune, Joseph M.

Immunol Rev ; 315(1): 126-153, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36960621

2.

Why and where an HIV cure is needed and how it might be achieved.

Ndung'u, Thumbi; McCune, Joseph M; Deeks, Steven G.

Nature ; 576(7787): 397-405, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31853080

3.

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.

Bacchus-Souffan, Charline; Fitch, Mark; Symons, Jori; Abdel-Mohsen, Mohamed; Reeves, Daniel B; Hoh, Rebecca; Stone, Mars; Hiatt, Joseph; Kim, Peggy; Chopra, Abha; Ahn, Haelee; York, Vanessa A; Cameron, Daniel L; Hecht, Frederick M; Martin, Jeffrey N; Yukl, Steven A; Mallal, Simon; Cameron, Paul U; Deeks, Steven G; Schiffer, Joshua T; Lewin, Sharon R; Hellerstein, Marc K; McCune, Joseph M; Hunt, Peter W.

PLoS Pathog ; 17(1): e1009214, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33465157

4.

Extending Gene Medicines to All in Need.

McCune, Joseph M; Kiem, Hans-Peter.

N Engl J Med ; 390(18): 1721-1722, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38657269

5.

Immune mechanisms at the maternal-fetal interface: perspectives and challenges.

PrabhuDas, Mercy; Bonney, Elizabeth; Caron, Kathleen; Dey, Sudhansu; Erlebacher, Adrian; Fazleabas, Asgerally; Fisher, Susan; Golos, Thaddeus; Matzuk, Martin; McCune, Joseph M; Mor, Gil; Schulz, Laura; Soares, Michael; Spencer, Thomas; Strominger, Jack; Way, Sing Sing; Yoshinaga, Koji.

Nat Immunol ; 16(4): 328-34, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25789673

6.

Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4⁺ T Cell Counts and Body Weight.

Swainson, Louise A; Ahn, Haelee; Pajanirassa, Priya; Khetarpal, Vinod; Deleage, Claire; Estes, Jacob D; Hunt, Peter W; Munoz-Sanjuan, Ignacio; McCune, Joseph M.

J Immunol ; 203(4): 899-910, 2019 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-31285277

7.

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.

Chitre, Avantika S; Kattah, Michael G; Rosli, Yenny Y; Pao, Montha; Deswal, Monika; Deeks, Steven G; Hunt, Peter W; Abdel-Mohsen, Mohamed; Montaner, Luis J; Kim, Charles C; Ma, Averil; Somsouk, Ma; McCune, Joseph M.

PLoS Pathog ; 14(3): e1006806, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29505600

8.

Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.

Méndez-Lagares, Gema; Lu, Ding; Chen, Connie; Terrault, Norah; Segal, Mark R; Khalili, Mandana; Monto, Alexander; Shen, Hui; Manos, M Michele; Lanier, Lewis L; Ryan, James C; McCune, Joseph M; Hartigan-O'Connor, Dennis J.

J Immunol ; 200(3): 1124-1132, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29263212

9.

Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-ß Signaling.

Bronevetsky, Yelena; Burt, Trevor D; McCune, Joseph M.

J Immunol ; 197(11): 4344-4350, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-27793996

10.

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

Henrich, Timothy J; Hatano, Hiroyu; Bacon, Oliver; Hogan, Louise E; Rutishauser, Rachel; Hill, Alison; Kearney, Mary F; Anderson, Elizabeth M; Buchbinder, Susan P; Cohen, Stephanie E; Abdel-Mohsen, Mohamed; Pohlmeyer, Christopher W; Fromentin, Remi; Hoh, Rebecca; Liu, Albert Y; McCune, Joseph M; Spindler, Jonathan; Metcalf-Pate, Kelly; Hobbs, Kristen S; Thanh, Cassandra; Gibson, Erica A; Kuritzkes, Daniel R; Siliciano, Robert F; Price, Richard W; Richman, Douglas D; Chomont, Nicolas; Siliciano, Janet D; Mellors, John W; Yukl, Steven A; Blankson, Joel N; Liegler, Teri; Deeks, Steven G.

PLoS Med ; 14(11): e1002417, 2017 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-29112956

11.

Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing.

Cunyat, Francesc; Rainho, Jennifer N; West, Brian; Swainson, Louise; McCune, Joseph M; Stevenson, Mario.

J Virol ; 90(14): 6255-6262, 2016 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-27122585

12.

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1ß: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.

Ladell, Kristin; Hazenberg, Mette D; Fitch, Mark; Emson, Claire; McEvoy-Hein Asgarian, Bridget K; Mold, Jeff E; Miller, Corey; Busch, Robert; Price, David A; Hellerstein, Marc K; McCune, Joseph M.

J Immunol ; 195(9): 4096-105, 2015 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-26416271

13.

Collaborative science to advance gene therapies in resource-limited parts of the world.

McCune, Joseph M; Stevenson, Susan C; Doehle, Brian P; Trenor, Cameron C; Turner, Emily H; Spector, Jonathan M.

Mol Ther ; 29(11): 3101-3102, 2021 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-34464598

14.

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

Serrano-Villar, Sergio; Sainz, Talia; Lee, Sulggi A; Hunt, Peter W; Sinclair, Elizabeth; Shacklett, Barbara L; Ferre, April L; Hayes, Timothy L; Somsouk, Ma; Hsue, Priscilla Y; Van Natta, Mark L; Meinert, Curtis L; Lederman, Michael M; Hatano, Hiroyu; Jain, Vivek; Huang, Yong; Hecht, Frederick M; Martin, Jeffrey N; McCune, Joseph M; Moreno, Santiago; Deeks, Steven G.

PLoS Pathog ; 10(5): e1004078, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24831517

15.

Distinct functional programming of human fetal and adult monocytes.

Krow-Lucal, Elisabeth R; Kim, Charles C; Burt, Trevor D; McCune, Joseph M.

Blood ; 123(12): 1897-904, 2014 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-24518760

16.

Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.

Palmer, Clovis S; Anzinger, Joshua J; Zhou, Jingling; Gouillou, Maelenn; Landay, Alan; Jaworowski, Anthony; McCune, Joseph M; Crowe, Suzanne M.

J Immunol ; 193(11): 5595-603, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25367121

17.

Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Hatano, Hiroyu; Yukl, Steven A; Ferre, April L; Graf, Erin H; Somsouk, Ma; Sinclair, Elizabeth; Abdel-Mohsen, Mohamed; Liegler, Teri; Harvill, Kara; Hoh, Rebecca; Palmer, Sarah; Bacchetti, Peter; Hunt, Peter W; Martin, Jeffrey N; McCune, Joseph M; Tracy, Russell P; Busch, Michael P; O'Doherty, Una; Shacklett, Barbara L; Wong, Joseph K; Deeks, Steven G.

PLoS Pathog ; 9(10): e1003691, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24130489

18.

Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.

Lee, Sulggi A; Sinclair, Elizabeth; Jain, Vivek; Huang, Yong; Epling, Lorrie; Van Natta, Mark; Meinert, Curtis L; Martin, Jeffrey N; McCune, Joseph M; Deeks, Steven G; Lederman, Michael M; Hecht, Frederick M; Hunt, Peter W.

J Infect Dis ; 210(3): 374-82, 2014 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-24585893

19.

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.

Byakwaga, Helen; Boum, Yap; Huang, Yong; Muzoora, Conrad; Kembabazi, Annet; Weiser, Sheri D; Bennett, John; Cao, Huyen; Haberer, Jessica E; Deeks, Steven G; Bangsberg, David R; McCune, Joseph M; Martin, Jeffrey N; Hunt, Peter W.

J Infect Dis ; 210(3): 383-91, 2014 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-24585899

20.

Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.

Hartigan-O'Connor, Dennis J; Lin, Din; Ryan, James C; Shvachko, Valentina A; Cozen, Myrna L; Segal, Mark R; Terrault, Norah A; Lanier, Lewis L; Manos, M Michele; McCune, Joseph M.

J Infect Dis ; 209(10): 1602-12, 2014 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-24325966

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