Lepidoptera (Crambidae, Noctuidae, and Pyralidae) Injury to Corn Containing Single and Pyramided Bt Traits, and Blended or Block Refuge, in the Southern United States.

Fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae); corn earworm, Helicoverpa zea Boddie (Lepidoptera: Noctuidae); southwestern corn borer, Diatraea grandiosella Dyar (Lepidoptera: Crambidae); sugarcane borer, Diatraea saccharalis F. (Lepidoptera: Crambidae); and lesser cornstalk borer, Elasmopalpus lignosellus Zeller (Lepidoptera: Pyralidae), are lepidopteran pests of corn, Zea mays L., in the southern United States. Blended refuge for transgenic plants expressing the insecticidal protein derivative from Bacillus thuringiensis (Bt) has recently been approved as an alternative resistance management strategy in the northern United States. We conducted a two-year study with 39 experiments across 12 states in the southern United States to evaluate plant injury from these five species of Lepidoptera to corn expressing Cry1F and Cry1Ab, as both single and pyramided traits, a pyramid of Cry1Ab×Vip3Aa20, and a pyramid of Cry1F×Cry1Ab plus non-Bt in a blended refuge. Leaf injury and kernel damage from corn earworm and fall armyworm, and stalking tunneling by southwestern corn borer, were similar in Cry1F×Cry1Ab plants compared with the Cry1F×Cry1Ab plus non-Bt blended refuge averaged across five-plant clusters. When measured on an individual plant basis, leaf injury, kernel damage, stalk tunneling (southwestern corn borer), and dead or injured plants (lesser cornstalk borer) were greater in the blended non-Bt refuge plants compared to Cry1F×Cry1Ab plants in the non-Bt and pyramided Cry1F×Cry1Ab blended refuge treatment. When non-Bt blended refuge plants were compared to a structured refuge of non-Bt plants, no significant difference was detected in leaf injury, kernel damage, or stalk tunneling (southwestern corn borer). Plant stands in the non-Bt and pyramided Cry1F×Cry1Ab blended refuge treatment had more stalk tunneling from sugarcane borer and plant death from lesser cornstalk borer compared to a pyramided Cry1F×Cry1Ab structured refuge treatment. Hybrid plants containing Cry1F×Cry1Ab within the pyramided Cry1F×Cry1Ab blended refuge treatment had significantly less kernel damage than non-Bt structured refuge treatments. Both single and pyramided Bt traits were effective against southwestern corn borer, sugarcane borer, and lesser cornstalk borer.

The evolution of faculty development in Canada since the 1980s: coming of age or time for a change?

AIM: To determine the current status of university based faculty development at Canadian Medical Schools. BACKGROUND: The roles and responsibilities of faculty members at Canadian medical schools are changing significantly as a consequence of influences such as the competency dictates outlined in the CanMEDS roles. One result of the changes is an increased need for faculty development to assist faculty members in carrying out their new and expanded roles. METHODS: The changing climate in medical schools, and the enhanced performance expectations of academic faculty, led us to conduct a survey of current faculty development practices in Canadian medical schools to determine what is being done to address the new and expanded expectations of faculty members. We used an on-line survey instrument based on surveys of faculty development conducted in 1987 and 1997. RESULTS: We received responses from faculty development directors at all 17 Canadian medical schools. Among the principal findings are a continued emphasis on faculty members' teaching roles, increased funding of faculty development activities at most schools, and a broadened emphasis on faculty roles other than teaching. Among these are research and scholarship, and management and administrative roles. The survey revealed a mismatch between what faculty development directors consider to be effective development practices and which practices are actually used in their schools. Another notable finding is the absence of credible faculty development impact studies. CONCLUSION: The 2007 survey of faculty development practices in Canadian medical schools indicates that teaching is still the number one priority for faculty members and the main focus of faculty development programs. There are notable efforts to help faculty members deal with their newly identified roles including those outlined in the CanMEDS framework. In looking forward, Canadian faculty development directors should continue their efforts to devise credible program evaluation methods. Furthermore, they should expand their thinking beyond Canada's borders. It is time to aggressively explore and understand the approaches and experiences which have proven successful internationally in the United States and Europe.

A pilot study designed to acquaint medical educators with basic pedagogic principles.

BACKGROUND: Faculty development activities in medical schools regularly target teaching behaviours but rarely address basic pedagogic principles underlying those behaviours. Although many teachers have an intuitive or tacit knowledge of basic pedagogic principles, overt knowledge of fundamental educational principles is rare. AIMS: We conducted a short-term pilot study designed to transform teachers' tacit knowledge into explicit knowledge of pedagogic principles. We hypothesized that conscious awareness of these principles will positively influence their teaching effectiveness. METHODS: The intervention included a workshop, provision of a workbook on pedagogic principles and free access to educational consultants. For the intervention, we chose a purposive sample of experienced teachers at our medical school. RESULTS AND CONCLUSIONS: Evaluation of the impact of the intervention using questionnaires and semi-structured interviews revealed three notable findings; 1. Participants were surprised to discover the existence of an extensive body of pedagogic science underlying teaching and learning. 2. They were enthusiastic about the intervention and expressed interest in learning more about basic pedagogic principles. 3. The knowledge acquired had an immediate impact on their teaching.

First Report of Powdery Mildew Caused by Leveillula taurica on Tomato and Pepper in Bolivia.

Chlorotic and necrotic lesions typical of powdery mildew caused by L. taurica were observed in several tomato (Lycopersicon esculentum) and pepper (Capsicum annuum) fields in Santa Cruz State, Bolivia near the town of Mairana during September 2004. The tomato cultivars affected were Santa Clara, Superman, and Cool 45. Symptoms included bright yellow chlorotic lesions or brown necrotic lesions on different age leaves. Examination of samples collected from several fields revealed sporulation of L. taurica on abaxial leaf surfaces. The fungus had branched conidiophores, a tapered or pyriform apical conidium, with other conidia being more cylindrical (1,2). Conidial size was approximately 60 × 18 µm. Only the Oidiopsis stage was observed. Disease severity was high and caused a significant amount of leaf necrosis and partial defoliation on tomato. Only sporadic lesions were observed on pepper cv. YoloWonder and no significant foliar damage was observed. The growing region receives approximately 75 mm of rainfall annually with most of the rainfall occurring between October and April. Thus, powdery mildew was observed near the end of the normal 5-month dry season. It is likely that the disease has been in the region for some time based on observations from field personnel. Although reported from several other South American countries, to our knowledge, this is the first report of this disease in Bolivia. References: (1) H. J. Boesewinkel. Bot. Rev. 46:167, 1980; (2) J. C. Correll et al. Plant Dis. 71:248, 1987.

Duration of antihypertensive effect of a single daily dose of hydrochlorothiazide.

To assess the duration of antihypertensive effect of a single daily dose of the short-acting diuretic hydrochlorothiazide, a double-blind crossover study was performed in 11 patients previously well controlled with diuretics. Each patient received hydrochlorothiazide 100 mg in the morning for 12 wk and blood pressure were recorded 4 times daily (8 A.M., 12 noon, 4 A.M., and 8 P.M) on 3 separate visits. The crossover design also included a 12-wk placebo period either preceding or following active therapy. Blood pressure control was excellent and sustained throughout the day in all patients studied, indicating that a single daily dose of hydrochlorothiazide is a suitable regimen for hypertension therapy. The use of a placebo period before initiating the trial and during the active part of the trial confirmed the observation that patients who have been adequately treated for long periods will maintain lowered blood pressure for a variable period after stopping therapy.

Antihypertensive efficacy of a single bedtime dose of methyldopa.

To compare the antihypertensive efficacy of methyldopa administered once at bedtime with the same total dose given three times daily, a double-blind crossover study was performed in 14 patients previously well controlled on methyldopa. Each patient received a total daily dose of 0.37 gm, 0.75 gm, or 1.5 gm of methyldopa, depending on the dose of drug that had previously been successful in that individual. The trial design included either 12 wk of methyldopa three times daily (TID) followed by 12 wk of single daily bedtime (HS) doses of methyldopa or administration of drug in the reverse order. Supine and erect blood pressures were recorded 4 times daily (8 a.m., 12 noon, 4 p.m., and 8 p.m.) every 4 wk throughout the study. Blood pressure control was excellent in all patients whether the drug was administered three times daily or at bedtime. Systolic pressures were slightly lower at 8 a.m., when methyldopa was given at bedtime than on doses three times daily, and systolic and diastolic pressures were slightly higher at 8 p.m. that at 8 a.m. on the bedtime regimen.

Undergraduate clinical education in internal medicine at Canadian medical schools.

PURPOSE: To document the characteristics of the clinical education in internal medicine of undergraduate medical students at Canadian medical schools. METHOD: A five-part questionnaire was sent in 1991-92 to the individuals responsible for supervising the internal medicine clerkships at all 16 Canadian medical schools. The questions were related to (1) tutors, hospitals, and inpatient clinical experiences of internal medicine clerks; (2) ambulatory care experiences; (3) evaluation methods; (4) "junior clerkships" (i.e., clinical courses that precede the clerkships); and (5) supervisors' opinions about changes needed to improve the clerkships. RESULTS: Responses were received from all schools. There was surprising uniformity in clinical education across Canada. Clinical education methods have changed very little over the past decade. In the opinion of the clerkship supervisors, there were too few committed clinical tutors, little evidence of use of newer evaluation methods, and inadequate ambulatory care instruction. CONCLUSION: The study results suggest that the clinical education in internal medicine of undergraduate medical students has changed little despite numerous calls for reform.

Assessing the value of student case write-ups and write-up evaluations.

To investigate the attitudes of medical students concerning the educational value of case write-ups and write-up evaluations and the usefulness of write-up evaluations in assessing clinical skills, the author surveyed 140 students at McGill University after they had completed a 10-week clinical course in internal medicine. He also surveyed internal medicine course directors at the 16 Canadian medical schools to determine their assessments of write-up evaluation practices in their departments. There was broad agreement among the students and directors that case write-ups and their evaluations are useful for learning, but there were major concerns about the variability of the criteria and standards for evaluation. Recommendations are presented.

Using focus groups to design a valid questionnaire.

The authors planned to study the roles and concerns of senior faculty members at their institutions. To elaborate the aims of their study and to help them design a valid questionnaire, they conducted focus groups with senior faculty. The authors describe how the information gleaned from the focus groups helped them develop their questionnaire.

Seven principles for teaching procedural and technical skills.

The authors developed a cognitive-theory-based checklist of seven important principles for teaching technical skills. They then used the checklist in a workshop for doctors who teach procedural and technical skills. Participants in the workshop found the principle-based approach to be more effective than the traditional "see one, do one, teach one" approach.

Program design and delivery in Canadian CME drug therapy courses.

OBJECTIVE: To examine how drug therapy course directors design and deliver drug therapy courses, and whether they employ adult education principles to assure effective education. DESIGN: Analysis of a three-part questionnaire sent to directors of drug therapy courses in Canada. PARTICIPANTS: The questionnaire was sent to all seven directors of drug therapy courses at medical schools that are accredited continuing medical education providers. RESULTS: All directors completed and returned the questionnaires. To decide on course content, most use feedback from previous course attendees, peer consultations, course committee member discussions and their own perceptions of learners' needs. Courses generally use conventional teacher-dominated technology rather than methods that emphasize active learner participation. CONCLUSION: Directors of Canadian continuing medical education drug therapy courses reasonably employ adult education principles when deciding learner needs and designing teaching vehicles.

Coding accuracy of hospital discharge data for elderly survivors of myocardial infarction.

OBJECTIVE: To assess the coding accuracy of primary and secondary discharge diagnoses in the Quebec hospital discharge database for elderly persons with myocardial infarction (MI). DESIGN: Retrospective chart review in a convenience sample of six Montreal hospitals. The diagnoses listed in the medical chart were compared with those listed in the hospital discharge database. For each subject, the Charlson comorbidity index was calculated twice, once based on the medical chart and again based on the hospital discharge database. PATIENTS: Subjects aged 65 years and over who had an MI coded as the primary discharge diagnosis in the hospital discharge database and who were discharged alive. MAIN RESULTS: For 234 MI survivors, the positive predictive value (ie, probability that a patient with MI reported in the hospital discharge database had an MI diagnosed by the discharging physician) for coding MI was 0.96 (95% CI 0.94, 0.98). Comorbid medical conditions and complications of the MI were under-reported in the hospital discharge database, which meant that the Charlson index based on the hospital discharge database was an average of 0.71 units lower than the Charlson index based on the medical chart. CONCLUSIONS: When studying survivors of MI by using hospital discharge databases, the advantages must be weighed against potential drawbacks in the quality of the information. Hospital discharge databases are almost as reliable as medical charts for identifying MI patients, but there is substantial under-reporting of comorbid medical conditions.

Developmental changes in associations among timber wolf (Canis lupus) postures.

I examined developmental changes in associations among components of timber wolf (Canis lupus) postural communication in two hand-reared pups between 15 and 85 days of age. The frequency with which select postural components co-occurred was scored from 180 randomly sampled frames of video records of these pups made during social interactions. I used this index of association as the basis for multidimensional scaling and cluster analyses. Relations among postural components became more structured with age. Two-dimensional models were found to account for associations among postures displayed at 69-85 and 32-67 days of age but not at 15-32 days of age. I interpret these orthogonal dimensions as continua of dominance to submission and seriousness to playfulness. These data suggest the intended messages contained in postural displays may depend on the specific combinations of components used.

Developmental changes in the sequential behavior of interacting timber wolf pups.

We used information statistics to quantify first-order sequential dependencies in the social behavior of two sibling wolf pups (Canis lupus). Sequential dependencies in the behavior of the individual pups increased between the first sample (18-32 days of age) and two later samples taken from 34-53 days and 64-106 days of age. Sequential dependencies between pups were greatest during the second age sampled. We relate these findings to changes in the importance and style of interactions. In the first 32 days, social co-actions primarily involved mutual mouthing and pushing. Between 34 and 53 days, when interactions frequently became aggressive, pups were most responsive to the actions of their partner and tail-raising predicted biting. By 64 days, play-chasing was the mode. By this age pups had formed a relationship, were less attentive to the specific actions of their partner, and biting was no longer predicted by tail-raising. These results illustrate the importance of considering demand characteristics in distinguishing capabilities from performance, and suggest that changing social organization may underlie developmental changes in behavior. We also speculate that during these play-like interactions, pups may gain control over expressive displays.

Educational benefits of blinding students to information acquired and management plans generated by other physicians.

At our university, Internal Medicine clerks are members of a team responsible for the care of patients hospitalized on a teaching ward. Clerks first encounter their patients after the latter have been fully worked up by other physicians who have examined them and initiated investigations and management. Clerks are thus deprived of the opportunity to practice information acquisition, hypothesis generation and problem solving. We therefore undertook a 'blinding' initiative wherein each clerk was required to work up at least one hospitalized patient per week without access to the patient chart and without knowledge of information acquired and hypotheses generated by other physicians. Weekly data collection during the 8-week experiment with 40 clinical clerks revealed that work up of 'blinded' patients was more time-consuming and more difficult than work up of unblinded patients. Clerks were appreciative of the educational value of blinding. Teaching faculty felt clerk 'blinding' to be a practical approach to approximating the true conduct of medical practice and as such was useful for student learning.

Characteristics of physicians who frequently prescribe long-acting benzodiazepines for the elderly.

Long-acting benzodiazepines (LABZs) are relatively contraindicated for elderly patients because they increase the risk of impaired cognitive function, falls, and hip fractures. The purpose of this study was to identify the characteristics of physicians who frequently prescribe LABZs for elderly patients. The authors examined the prescribing profile of 4,976 physicians who saw at least 20 elderly Quebec medicare registrants in 1990. Physicians who frequently prescribed LABZs for their elderly patients were more likely to have graduated before 1979, to be general practitioners as opposed to specialists, to practice in long-term care settings, and to have graduated from a medical school in Quebec as opposed to other schools in Quebec, in other provinces, or in other countries. The authors have identified several characteristics of physicians who frequently prescribed LABZs for the elderly. Strategies to improve prescribing in this field should target this group of physicians.

Aphicide persistence on spinach and mustard greens.

Laboratory bioassays with green peach aphids, Myzus persicae (Sulzer), were conducted on samples from field grown spinach and mustard greens to determine the persistence of triazamate, dimethoate, and mevinphos. Treatment with each insecticide resulted in similar mortality initially on both crops. Mortality on samples from mevinphos treated plants declined considerably by 1 d after treatment. Dimethoate persisted for > 4 d at a level that would kill at least some aphids during the allotted time. Persistence of triazamate and dimethoate activities were similar on spinach. Triazamate, however, resulted in greater aphid mortality through time on mustard greens than did dimethoate.

[Characteristics of physicians prescribing more psychotropic drugs to women than to men]. / Caractéristiques des médecins prescrivant des psychotropes davantage aux femmes qu'aux hommes.

In industrialized countries, gender differences observed in health condition and the use of medical services appear insufficient to explain a greater consumption of psychotropic drugs in women than men. The authors have tested the hypothesis that physician prescribing patterns largely explains this observation. They demonstrate, using data from the Régie de l'assurance maladie du Québec for people aged 65 and over, that physicians' sociodemographic and practice characteristics are significantly associated with the percentage of men and women who receive a psychotropic drug prescription in their practice.