Rapid development of application-specific flexible MRI receive coils.

Over the last 30 years, there have been dramatic changes in phased array coil technology leading to increasing channel density and parallel imaging functionality. Current receiver array coils are rigid and often mismatched to patient's size. Recently there has been a move towards flexible coil technology, which is more conformal to the human anatomy. Despite the advances of so-called flexible surface coil arrays, these coils are still relatively rigid and limited in terms of design conformability, compromising signal-to-noise ratio (SNR) for flexibility, and are not designed for optimum parallel imaging performance. The purpose of this study is to report on the development and characterization of a 15-channel flexible foot and ankle coil, rapidly designed and constructed using highly decoupled radio-frequency (RF) coil elements. Coil performance was evaluated by performing SNR and g-factor measurements. In vivo testing was performed in a healthy volunteer using both the 15-channel coil and a commercially available 8-channel foot coil. The highly decoupled elements used in this design allow for extremely rapid development and prototyping of application-specific coils for different patient sizes (adult vs child) with minimal additional design consideration in terms of coil overlap and geometry. Image quality was comparable to a commercially available RF coil.

Membrane and bubble oxygenators compared by preservation of myocardial function.

Membrane oxygenators reputedly preserve erythrocytes, platelets, kidneys, brain and lungs better than bubble oxygenators; preservation of ventricular function by the two types of oxygenator is compared in isolated hearts, extremely sensitive to imperfections of perfusion, by isovolumic tests which are simple and accurate, especially for evaluating compliance. Canine hearts were perfused for three hours with either disposable bubble (Temptrol) or membrane (Lande-Edwards) oxygenators. Values at a standard point on regression slopes os isovolumic contractile force, velocity and compliance (volume) against end-diastolic pressure were used to express final functions as percentages of initial ones. Terminal proportional ventricular weight was an index of oedema. The final mean percentages with standard error measurements of initial values for the 12 hearts perfused on buble oxygenators and the 10 on membrane oxygenators were, respectively: 97 +/- 11.5% and 87 +/- 10.7% for contractile force, 117 +/- 23.1% and 88 +/- 10.44% for contractile velocity, and 97.2 +/- 8.48% and 117.3 +/- 12.5% for ventricular compliance, which was the function nearest to showing a significant difference with P less than 0.1. There was no significant difference in weights. This membrane oxygenator, as cheap and simple as conventional ones, probably has similar advantages for the myocardium as for other tissues.

Protection of the ischaemic myocardium by glucose-insulin-potassium infusion assessed by ventricular function and electron microscopy.

The protective effect of GIK infusion on the ischaemic myocardium was assessed by isovolumic function tests and electron microscopy. There were two control groups, group 1 hearts underwent 2 hours of continous normothermic cross-perfusion and group 2 hearts endured 2 hours of ischaemia. Group 3 hearts were administered GIK solution prior to ischaemic arrest. The group 3 hearts showed less loss of contractile force and contractile velocity from the ischaemic period compared to group 2 hearts, but no benfit was shown in terms of compliance. Electron microscopic examination showed slightly less damage in the group 3 hearts compared to group 2 hearts. Group 1 hearts maintained better function than either of the other two groups. Ultrastructure was not examined in group 1 hearts. A slight protective effect of GIK on the ischaemic myocardium was thus confirmed.