Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma.

PURPOSE: To evaluate the influence of fraction size, overall time, total dose, and other prognostic factors on local control of T1 and T2 glottic carcinomas. METHODS AND MATERIALS: Between 1956 and 1995, 398 consecutive patients with early glottic carcinoma (315 T1 and 83 T2) were treated with once-a-day definitive radiotherapy at the University of California, San Francisco, and associated institutions. Treatment was delivered 5 days per week. Minimum tumor dose ranged from 46.6 to 77.6 Gy (median: 63 Gy). The fraction size was < 1.8 Gy in 146; 1.8-1.99 Gy in 128; 2.0-2.24 Gy in 62, and > or = 2.25 Gy in 62 patients. Overall time ranged from 34 to 75 days (median: 50 days). The majority of patients treated with a fraction size of 2.25 Gy completed therapy within 43 days. Median follow-up of all alive patients was 116 months (range 3-436 months). RESULTS: Five-year local control was 85% for T1 and 70% for T2 glottic carcinomas (p = 0.0004). For T1 lesions, within the dose and time range evaluated, there was no apparent relationship between fraction size, overall time, total dose, and local control on multivariate analysis. Treatment era was the only significant prognostic factor (p = 0.02), and anterior commissure (AC) involvement was of borderline significance (p = 0.056). Five-year local control was 77% for patients treated between 1956-1970, 89% for between 1971-1980, and 91% for between 1981-1995; 80% for patients with AC involvement and 88% for those without. For T2 lesions, prognostic factors for local control on multivariate analysis were: overall time (p = 0.003), fraction size (p = 0.003), total dose (p = 0.01), impaired vocal cord mobility (p = 0.02), and subglottic extension (p = 0.04). Five-year local control was 100% for T2 lesions treated with overall time < or = 43 days vs. 84% for overall time > 43 days; 100% for fraction size > or = 2.25 Gy vs. 44% for fraction size < 1.8 Gy; 78% for total dose > 65 Gy vs. 60% for total dose < or = 65 Gy; 79% for normal cord mobility vs. 45% for impaired cord mobility, and 58% for lesions with subglottic extension vs. 77% for those without. The severe complication rate for the entire group was low: 1.8%. CONCLUSIONS: Total dose, fraction size, and overall time were significant factors for local control of T2 but not T1 glottic carcinomas. Anterior commissure involvement was associated with decreased local control for T1 but not T2 lesions. For T1 lesions, local control improved over the treatment era. For T2 lesions, local control decreased with impaired cord mobility and subglottic extension.

Bilateral arcs using "averaged beam's eye views": a simplified technique for delivering 3-D based conformal radiotherapy.

The purpose of this study is to describe a conformal radiotherapy technique for treating only the prostate with bilateral 120 degrees arcs using "averaged beams-eye-views" (A-BEV). For this study a CT scan from a patient with a large prostate but with a low risk for seminal vesicle involvement was chosen for comparing several different treatment techniques. Dose volume histograms (DVHs) of the prostate, femoral heads, bladder, and rectum were compared for plans using "standard" bilateral 120 degree unblocked arcs (8 x 8 and 9 x 9 cm), similar sized arcs with "generic" (small corner) blocks applied, arcs using hand drawn "semi-conformal" blocks added, and arcs using the A-BEV. The A-BEV was generated by averaging the shapes of fixed lateral and oblique BEVs from a six-field plan. These arc techniques were compared to four-field conformal (4-FC) and six-field conformal (6-FC) techniques. The addition of generic corner blocks to a 9 x 9 field resulted in a more favorable dose distribution than using open unblocked 9 x 9 arcs. The technique employing the A-BEV resulted in an improvement in the DVHs compared to other arc techniques and to 4-FC techniques. The dose volume histograms associated with using this technique approached those associated with using a 6-FC technique. Treating only the prostate with blocked arcs generated using an A-BEV results in an improved dose distribution compared to unblocked arcs and 4-FC techniques. This blocked arc technique also results in a DVH that is comparable to using a more complex 6-FC technique. Blocks that are drawn on manually reduce the dose to the surrounding normal tissues but are associated with a greater risk of underdosing the target volume. This problem is diminished when computer generated conformal blocks are used.

Total skin electron beam therapy in mycosis fungoides.

Thirty-nine patients with mycosis fungoides were treated with total skin electron beam irradiation from 1971 to 1976, and all received minimum follow-up of 12 months. Details of treatment technique and dosimetry are given. Sixteen patients cleared completely. Seven patients are in long-term remission (1 1/2 to 4 1/2 years). Eleven patients died. Those who failed are now being treated with topical therapy with varying degrees of control. Some have been retreated with local irradiation. Most of the patients had extensive disease; for this group, total skin electron beam therapy was especially useful, as many of those who failed developed only minimal disease that was well controlled by topical measures.

137Cs afterloading intrauterine packing for stage I and stage II adenocarcinoma of the endometrium.

Eleven patients with Stage I or Stage II adenocarcinoma of the endometrium were treated with 137Cs afterloading intrauterine packing. Treatment results and complications were similar to those obtained with radium afterloading tandems and colpostats (20 patients) and Heyman packing (2 patients). 137Cs is preferable in patients with roomy or irregular intrauterine cavities and also offers reduced radiation exposure to personnel.