RESUMO
During an outbreak of influenza specimens were obtained from 21 patients with influenza-like illnesses and from 29 healthy subjects in close contact with the patients. Throat washings from 12 of the patients were positive for influenza virus but virus was not detected from the blood specimens. One healthy contact became ill 12 hours after the specimens were obtained, and the virus was isolated from his blood and throat washings. The remaining contacts showed no clinical illness; but the virus was isolated from the throat washings of four of them, with no viral isolation from the blood specimens.
Assuntos
Sangue/microbiologia , Portador Sadio/microbiologia , Influenza Humana/microbiologia , Orthomyxoviridae/isolamento & purificação , Testes de Inibição da Hemaglutinação , Testes de Hemaglutinação , Humanos , Influenza Humana/diagnóstico , Faringe/microbiologiaRESUMO
Co-trimoxazole, a mixture of one part trimethoprim (TMP) and five parts of sulphamethoxazole (SMX) in fixed ratio was given to 48 children aged between one and 48 months twice daily for up to seven days. Twenty were relatively healthy and 28 were very ill. Dosage was based on age. Plasma concentrations of both drugs were measured just before a dose was due and some three hours later. They were in the efective but not toxic range and serve to justify the simple regimen which generated them.
Assuntos
Sulfametoxazol/administração & dosagem , Trimetoprima/administração & dosagem , Pré-Escolar , Combinação de Medicamentos , Humanos , Lactente , Sulfametoxazol/sangue , Suspensões , Trimetoprima/sangueRESUMO
A comparison of tetracycline, chloramphenicol, and trimethoprim/sulphamethoxazole showed that all hasten the eradication of Vibrio cholerae from the stools of patients with cholera.A four-day period of tetracycline or trimethoprim/ sulphamethoxazole was adequate for eradicating V. cholerae from the stools of all patients, but three days, as suggested by the W.H.O. Expert Committee, was not. Four days of chloramphenicol therapy was sufficient for most patients, but a minority required up to seven days' therapy.Purging produced reappearance of V. cholerae in the stools of one-eighth of the patients who had had three successive daily negative stool cultures; such patients are a potential danger to the population.