1.
Molecules
; 29(1)2024 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38202823
RESUMO
Quercetin is a flavonoid with significant biological and pharmacological activity. In this paper, quercetin was modified at the 3-OH position. Rutin was used as a raw material. We used methyl protection, Williamson etherification reactions, and then substitution reactions to prepare 15 novel quercetin derivatives containing a quinoline moiety. All these complexes were characterized by 1H NMR, 13C NMR, IR and HRMS. Of these, compound 3e (IC50 = 6.722 µmol·L-1) had a better inhibitory effect on human liver cancer (HepG-2) than DDP (Cisplatin) (IC50 = 26.981 µmol·L-1). The mechanism of the action experiment showed that compound 3e could induce cell apoptosis.