RESUMO
We present an endometrial Müllerian adenosarcoma in which the sarcomatous component showed prominent nests of foamy cells that accounted for 50% of the neoplastic mesenchyma. Such foamy cells showed occasional cytological atypias and immunohistochemical features of histiocytic (macrophagic differentiation in the absence of changes that could substantiate the presence of an inflammatory infiltration of foamy histiocytes. These facts suggest histiocytic differentiation from neoplastic mesenchymal cells. Such differentiation has been reported in association with malignant mixed mesodermal tumor, but not in Müllerian adenosarcoma.
Assuntos
Neoplasias do Endométrio/patologia , Neoplasias Embrionárias de Células Germinativas/patologia , Tumor de Wilms/patologia , Biomarcadores Tumorais , Feminino , Células Espumosas/ultraestrutura , Histiócitos/ultraestrutura , Humanos , Histerectomia , Pessoa de Meia-Idade , Ovariectomia , Salpingostomia , Resultado do TratamentoRESUMO
Morphologic studies were performed on 25 uteri obtained at different times during the menstrual cycle, ranging from 2 to 140 hours following the onset of menstruation. The amount of endometrium desquamated varied; usually only the more superficial parts--the compacta layer and small areas of the spongiosa--were shed, but in some instances desquamation extended almost to the muscularis. The remaining spongiosa, depleted and shrunken, is misleading in its appearance, resembling a basalis layer. Actually, such a layer appears morphologically distinct only during the initial parts of the cycle and undergoes secretory changes at the same rate as the rest of the endometrium. Desquamation and regeneration coexist, desquamation appearing almost complete by 60 hours, whereas regenerating epithelium is seen as early as 36 hours. Complete regeneration takes place by 140 hours after the initiation of menstruation.
Assuntos
Endométrio/fisiologia , Menstruação , Endométrio/anatomia & histologia , Epitélio/anatomia & histologia , Feminino , Humanos , Regeneração , Fatores de TempoRESUMO
The pathology of 1436 cases of female genital tuberculosis (FGTB) observed from 1946 to 1977 is reviewed. The frequency of FGTB was highest in 1956, when it represented 5.5% of all gynecologic pathology specimens. The incidence declined in 1964 as a result of a nationwide antituberculosis campaign, falling to 0.27% in 1977. Sixty-six percent of the patients were 25-35 years of age, and 11% were postmenopausal. All patients presented with either primary (94%) or secondary (6%) infertility. The percentages of involvement of the different parts of the genital tract were: fallopian tubes 100%, endometrium 79%, cervix 24%, vulva and vagina 0.07%, and ovaries 11%. The clinicopathologic and diagnostic criteria of FGTB in the different regions are described, and special attention is paid to the effects of specific treatment on the tuberculous lesion.