Detalhe da pesquisa
1.
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J Org Chem
; 81(6): 2261-79, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26940174
2.
Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo.
Chembiochem
; 16(6): 903-8, 2015 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25786782
3.
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
J Am Chem Soc
; 136(49): 16958-61, 2014 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25434769
4.
Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.
RNA
; 18(3): 557-68, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22294662
5.
Prevalence, severity and risk factors of psychiatric disorders amongst sexual and gender diverse young people during the COVID-19 pandemic: A systematic review.
Clin Child Psychol Psychiatry
; : 13591045241229751, 2024 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290723
6.
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
J Med Chem
; 66(4): 2506-2523, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757090
7.
Discovery of a novel deaminated metabolite of a single-stranded oligonucleotide in vivo by mass spectrometry.
Bioanalysis
; 11(21): 1955-1965, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829055