RESUMO
The association cotrimoxazole-tricyclic antidepressants seems to involve a rapid relapse of the depressive states continuously treated with the latter drugs. Five cases are reported. Mechanisms of this unknown drug interaction are discussed. The hypothesis of an enzymatic induction is not the most probable. A central inhibition of the tricyclic antidepressants seems to be possible but needs to be supported by further evidence.
Assuntos
Anti-Infecciosos/metabolismo , Antidepressivos/metabolismo , Sulfametoxazol/metabolismo , Trimetoprima/metabolismo , Transtorno Depressivo/tratamento farmacológico , Transtorno Depressivo/metabolismo , Combinação de Medicamentos/metabolismo , Interações Medicamentosas , Indução Enzimática , Feminino , Humanos , Fígado/enzimologia , Masculino , Pessoa de Meia-Idade , Recidiva , Combinação Trimetoprima e SulfametoxazolRESUMO
In mass vaccination programmes, the jet-injection of vaccine may have considerable operational advantages over the classical techniques. The technical performance of two models of jet-injector, the Dermo-Jet and the Ped-O-Jet, in BCG vaccination was assessed in a number of studies which are reviewed by the authors. It is shown that the jet-injectors do not administer the full dose for which they are calibrated and that the size of the vaccination lesion varies more than after vaccination by syringe.By increasing the dosage considerably, the results of vaccination by jet-injection may be improved to a certain extent but the risk of unpleasant reactions is also increased.