Long-term effects of bone marrow transplantation on dental status in children with leukaemia.

Minimal data about oral and dental health in long-term survivors after BMT are available. We studied the dental status of 27 children (19 males, eight females) with leukaemia, followed up with a routine oral examination, panoramic tomogram and, when necessary, an endoral radiograph at a median of 2 years (range 1-10) after BMT. Community periodontal index treatment necessity (CPITN), dental caries, missing or filled permanent teeth (DMFT) and dento-facial alterations according to WHO criteria were registered and evaluated. Median age of the patients at BMT was 9 years (range 1.1-17.9). The mean DMFT score ranged from 1.6 to 12.4 according to age at examination and was slightly higher than that which we previously reported in children who received chemotherapy alone. CPITN showed the presence of soft deposits in 77.7%, serious gingivitis in 59.2% and parodontal involvement in 3.7% of cases. Dento-facial abnormalities were found in 55.5% of patients, while 62.9% of the patients had tooth abnormalities or agenesis. Nine out of 27 patients (33%) had root hypoplasia. A negative impact on DMFT index due to multiple post-BMT factors was found. Age is the crucial factor in determining a developmental defect of enamel and root. The follow-up of long-term survivors after BMT should include regular dental examination.

Miokamycin penetration into oral cavity tissues and crevicular fluid.

Diffusion of miokamycin into gum, maxillary-mandibular bone and crevicular fluid was studied in human beings. The antibiotic concentrations were determined in specimens at different times after oral administration of 600 mg in a single dose of miokamycin. Peak serum levels (2.32 +/- 0.67 mcg/ml) were found at the first hour after dosage. In healthy gum tissue the highest antibiotic levels (1.44 +/- 0.34 mcg/gr) were observed at the second hour, while in the inflamed gum miokamycin penetrates more rapidly, being, as in serum at the highest levels detectable during the first hour. In the bone of the maxilla or mandible the highest levels of miokamycin (0.88 +/- 0.13 mcg/gr) were detected at the second hour after treatment. In the crevicular fluid miokamycin showed a similar profile as that in serum, since the peak levels were reached at the first hour (2.4 +/- 0.88 mcg/ml, but the decrease of the antibiotic occurred more slowly than in serum. Miokamycin rapidly penetrates into tissues and fluids of oral cavity. A single oral dose of 600 mg guarantees antibacterial levels against susceptible bacteria over six hours.

[Osteomas of the jaws. A clinical and rehabilitative problem]. / Osteomi dei mascellari. Un problema clinico e riabilitativo.

The authors study, based on three cases of maxillary osteoma brought to their attention, evaluates the most suitable type of operation to perform, and the method with which to attention which to approach the problem of postoperative functional rehabilitation. This pathological condition is characterized by slow developments and the late appearance of symptoms deriving from the invasion of surrounding tissues. The chosen technique is surgery, involving the removal of the neoplasm. The benign nature of the neoplasm makes conservative surgery possible, including the partial removal of the neoplasm, in order to preserve the bone tissue indispensable for prosthetic rehabilitation. In cases in which the neoplasm spreads to surrounding tissues, in which more destructive surgery is required with an attendant loss of considerable portions of bone, we have used osteo-muscular pedicle flaps in combination with implantation techniques to obtain adequate functional and prosthetic rehabilitation.

[Implant-prosthetic rehabilitation in posttraumatic maxillomandibular tissue losses]. / Riabilitazione implanto-protesica nelle perdite di sostanza maxillo-mandibolari post-traumatiche.

Trauma in the maxillary-facial region can causes loss of mucous, dental and bone tissues, particularly in cases of ballistic trauma in which the explosive force disperses the affected tissues to some distance. This circumstance greatly complicates functional rehabilitation, a process requiring not only the construction of prostheses to replace the lost dental structures, but also the reconstruction of the mucous and bone tissues that will support the prostheses. Using methods involving the formation of pedicle bone grafts and the use of implantation techniques, it has been possible to guarantee a satisfactory functional rehabilitation, and in addition good results from the point of view of appearance have been obtained.

Probing the order-to-chaos region in superdeformed 151Tb and 196Pb nuclei with continuum gamma transitions.

The gamma decay associated with the warm rotation of the superdeformed nuclei 151Tb and 196Pb has been measured with the EUROBALL IV array. Several independent quantities provide a stringent test of the population and decay dynamics in the superdeformed well. A Monte Carlo simulation of the gamma decay based on microscopic calculations gives remarkable agreement with the data only assuming a large enhancement of the B(E1) strength for 1-2 MeV gamma rays, which may be related to the evidence for octupole vibrations in both mass regions.

[Periodontal conditions in growth age patients treated for leukemia with chemotherapy and radiation therapy protocols]. / Condizioni parodontali di soggetti trattati per leucemia nell'eta evolutiva con protocolli di terapie chemioterapiche radianti.

Patients affected by acute leukemia under radiotherapy and chemotherapy, less them 12 years ols were investigated about periodontal health. Patients were in total remission. Clinical and radiological X-Ray exams investigated soft deposits, calculus, intensive gingivitis, periodontal lesions and CPITN index. The Authors concluded that indices of these patients are better than in normal subjects.

[Agenesis of the upper lateral incisor: orthodontic therapy and replacement]. / L'agenesia dell'incisivo laterale superiore: terapia ortodontica e di sostituzione.

In this paper the Authors outline an uneven prevalence of superior lateral incisors agenesis. The treatment of this situation can be accomplished by various methods. It is possible to obtain the complete closure of dental spaces or maintain the physiological space. The Authors present four cases of young patients in which they decided to maintain orthodontically the space and to put them adhesive bridges.

[Use of fibrin glue in oral surgery]. / L'impiego della colla di fibrina in chirurgia orale.

Patients with progressive thromboembolic diseases usually are administered a daily therapy with anticoagulants-antiaggregants drugs: oral surgical procedures may be performed in these conditions without reduction of the systemic therapy, using topically fibrin glue.

[Drugs with contraceptive actions and periodontal status. Epidemiological survey]. / Farmaci ad azone contraccetiva e condizioni parodontali. Indagine epidemiologica.

PIP: Many Authors agree about a relationship between higher estroprogestinic levels and periodontal inflammation. This study tries to define the relationship between oral contraceptives (OC) and specific gingival signs, like bleeding and plaque. 51 women (15 to 19 years) were studied while using OC, and 36 of the same age group were studied as controls. Only women who had no past medical history of hormone imbalance, diabetes mellitus or dentures were selected. The patients were examined at the beginning of the study and were assigned scores related to the amount of plaque, inflammation and pockets (Loe and Silness gingival index). Use of alcoholic beverages, medications, tobacco, and caffeine were also noted. The only significant difference between the control group and the women taking OC was cigarette smoking: 52.9% versus 41.6% respectively. The average time of treatment was 11.5+5 months. No changes were observed in the buccal and lingual mucosa in both populations. The plaque indexes were very close. The bleeding was significantly higher in the group using OC; same for the gingival index. Pockets deeper than 2 mm were present in 33.3% of the treated women, versus 13.8% of the controls. The results point out a significant direct relationship between OC and gingival inflammation after several months of use. It possible that by prolonging the length of the study the gingival lesions would become even more significant.^ieng

[DMFT index values in patients treated for leukemia during growth]. / Valori dell'indice DMFT in soggetti trattati per leucemia nell'eta evolutiva.

Patients affected by acute leukemia under radiotherapy and chemotherapy, less than 12 years old were investigated about DMFT index. Patients were in total remission. All erupted permanent teeth, with attention to an eventual oligodontia of non erupted teeth also, excluding third molars, were investigated by clinical and X-Ray examination. Authors concluded that there is no difference between these patients and normal subjects for this index.

Compound and rotational damping in warm deformed rare-earth nuclei.

The gamma decay in the quasicontinuum from selected configurations of the rotational nucleus 163Er has been measured with the EUROBALL array. A new analysis technique has allowed for the first time to directly measure the compound and rotational damping widths Gamma (micro) and Gamma (rot). Values of Gamma (micro) approximately 20 keV and Gamma (rot) approximately 200 keV are obtained in the spin region I approximately 30-40 variant Planck's over 2pi, in good agreement with microscopic cranked shell model calculations. A dependence of Gamma (micro) and Gamma (rot) on the K-quantum number of the nuclear states is also presented.