Detalhe da pesquisa
1.
Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature
; 629(8013): 945-950, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38720069
2.
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Bioorg Med Chem Lett
; 27(11): 2559-2566, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431879
3.
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
J Pharmacol Exp Ther
; 359(1): 194-206, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432892
4.
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Bioorg Med Chem Lett
; 26(9): 2339-43, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017115
5.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett
; 26(23): 5695-5702, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27839686
6.
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
J Neurosci
; 34(21): 7190-7, 2014 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24849353
7.
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
J Pharmacol Exp Ther
; 348(1): 153-64, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24142912
8.
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Bioorg Med Chem Lett
; 23(12): 3640-5, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23652221
9.
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Bioorg Med Chem Lett
; 23(21): 5829-32, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24075732
10.
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorg Med Chem Lett
; 20(18): 5480-3, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709545
11.
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorg Med Chem Lett
; 20(18): 5536-40, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709552
12.
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem Lett
; 20(24): 7479-82, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106456
13.
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorg Med Chem Lett
; 19(18): 5334-8, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683443
14.
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorg Med Chem Lett
; 19(18): 5329-33, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19674896
15.
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
Assay Drug Dev Technol
; 17(7): 310-321, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31634018
16.
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
Mol Pharmacol
; 74(5): 1476-84, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18728100
17.
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorg Med Chem Lett
; 18(5): 1696-701, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18243692
18.
3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Bioorg Med Chem Lett
; 18(6): 1963-6, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289851
19.
Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.
Diabetes
; 55(4): 1034-42, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16567526
20.
Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
J Pain
; 8(4): 315-24, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17175203