What's new in the causes of hemorrhage in acute myelogenous leukemia?

Hemorrhages in AML are still a major problem, although not the most important and different factors are involved in its genesis. The causes that predispose an AML patient to bleed will be reviewed, the hypotheses concerning the coagulation disorder specially found in the FAB M3 type will be discussed and the increasingly recognized role of plasminogen activators and enzymes released from blasts will be emphasized.

[Chronic myeloid leukemia and non Hodgkin lymphoma in the same patient. Clinical case]. / Ocurrencia de leucemia mieloide crónica y linfoma no Hodgkin en un mismo paciente: caso clínico.

Chronic myeloid leukemia is a myeloproliferative disorder caused by a clonal disturbance of the trunk cell and the accumulation of granulocytic series in the marrow, blood and other organs. We report a 63 years old male, carrier of a chronic myeloid leukemia whose clinical condition was complicated by the appearance of a T cell lymphoma. He was subjected to chemotherapy, that reduced the size of adenopathies and improved his general condition. Further studies are required to determine if there is a relationship between these two clinical entities.

[Hodgkin's disease: relapse after 16 years of continuous remission]. / Enfermedad de Hodgkin: recaída tras 16 años de remisión continuada.

We report a boy in whom and advanced Hodgkin's disease, nodular sclerosis variety, was diagnosed at 5 years of age and treated with exclusive chemotherapy. After 16 years of remission, he presented with a relapse of the disease, with a different histological pattern and was subjected to chemotherapy (C-MOPP/AVB) and unilateral axillary irradiation, obtaining a complete remission of the disease. Four months later, the patient is asymptomatic and without evidences of relapse.