4-[(Dieth-oxy-phosphino-yl)meth-yl]benzoic acid.

In the title compound, C(12)H(17)N(2)O(5)P, the phospho-nate group is almost orthogonal to both the ethyl groups, with a dihedral angle of 83.75 (11)°. In the crystal, mol-ecules are linked into centrosymmetric dimers via pairs of O-H⋯O hydrogen bonds with an R(2) (2)(20) graph-set motif. The crystal structure is further consolidated by weak C-H⋯π inter-actions.

Diethyl [(3-cyano-1-phenyl-sulfonyl-1H-indol-2-yl)meth-yl]phospho-nate.

In the title compound, C(20)H(21)N(2)O(5)PS, the indole ring is essentially planar, with a maximum deviation of -0.0083 (18) Å. The methyl C atom of the methyl-phospho-nate group and the S atom lie 0.104 (2) and -0.2158 (6) Å, respectively, from the indole mean plane. The sulfonyl-bound phenyl ring is almost perpendicular to the indole ring system, with a dihedral angle of 82.30 (8)°. The ethyl side chains are disordered over two sets of sites, with occupancy factors of 0.737 (5)/0.263 (5) and 0.529 (11)/0.471 (11). In the crystal, mol-ecules are linked into centrosymmetric dimers via C-H⋯O hydrogen bonds, resulting in an R(2) (2)(18) graph-set motif. The crystal structure is further stabilized by C-H⋯π inter-actions.

Synthetic studies on indolocarbazoles: total synthesis of staurosporine aglycon.

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

Lewis acid-mediated Michaelis-Arbuzov reaction at room temperature: a facile preparation of arylmethyl/heteroarylmethyl phosphonates.

A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis-Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.