Ten simple rules for socially responsible science.

Guidelines concerning the potentially harmful effects of scientific studies have historically focused on ethical considerations for minimizing risk for participants. However, studies can also indirectly inflict harm on individuals and social groups through how they are designed, reported, and disseminated. As evidenced by recent criticisms and retractions of high-profile studies dealing with a wide variety of social issues, there is a scarcity of resources and guidance on how one can conduct research in a socially responsible manner. As such, even motivated researchers might publish work that has negative social impacts due to a lack of awareness. To address this, we propose 10 simple rules for researchers who wish to conduct socially responsible science. These rules, which cover major considerations throughout the life cycle of a study from inception to dissemination, are not aimed as a prescriptive list or a deterministic code of conduct. Rather, they are meant to help motivated scientists to reflect on their social responsibility as researchers and actively engage with the potential social impact of their research.

Beliefs About the Inevitability of Sexual Attraction Predict Stereotypes About Asexuality.

Similar to other sexual minorities, asexual individuals often face prejudice and stereotyping. However, the source of these attitudes and beliefs is not well understood. We hypothesized that asexual stereotypes stem from the belief that sexual attraction is an inevitable part of human development. This attraction inevitability assumption can lead to the deduction that people who identify as asexual do so because they are going through a transitory stage or excusing socially avoidant tendencies. To test this stereotype deduction account, we examined whether specific asexual stereotypes (immaturity and non-sociality) were associated with adherence to the attraction inevitability assumption. Heterosexual participants (N = 322; 201 women, 114 men; mean age 34.6 yrs.) from the UK and the US read vignettes describing a target character that was either asexual or heterosexual. People who assumed that attraction is inevitable were more likely to evaluate asexual targets (but not heterosexual targets) as immature and non-social. The impact of the sexual inevitability assumption was present even when social dominance orientation, an attitude closely related to negativity toward all sexual minorities, was accounted for. Participants who adhered to the attraction inevitability assumption also showed a reduced inclination to befriend asexual individuals. These findings suggest that generalized negativity toward sexual minorities does not fully explain stereotypes and prejudice against asexual people. Instead, the current study highlights how perceived deviation from the shared understanding of sexuality uniquely contributes to anti-asexual bias.

A brief guide to situating the neuroscience of Black and White civilian arrests in a broader social context.

This commentary provides some guidance to reading and interpreting the results reported in Dang et al. (2022). In light of the recent events of police violence and the public interest such important topics, we believe it is warranted to provide some guidance to interpreting the findings of this article for readers from the broader scientific community and the general public. We focus on the distinction between the reported results and their interpretation, conveying the scientific method's subtleties to the larger audience, and situating the findings in a broader context.

Distinct Neural Suppression and Encoding Effects for Conceptual Novelty and Familiarity.

Like yin and yang, novelty and familiarity are typically described as separate-yet-complementary aspects of an experience, two ends of a single continuum. However, novelty and familiarity are also multifaceted. For instance, novelty can sometimes result in enhanced mnemonic performance, whereas at other times familiarity is better remembered. As previous investigations focused primarily on the experimental aspect of novelty, the mechanisms supporting conceptual novelty (the novel combination of two previously unrelated existing concepts) remain unclear. Importantly, conceptual novelty can be recognized as such only when compared with preexperimental familiar knowledge, regardless of experimental status. Here we applied a combined repetition suppression/subsequent memory fMRI paradigm, focusing on the conceptual aspect of novelty and familiarity as the subject matter. Conceptual novelty was characterized by sustained neural activity; familiarity, on the other hand, exhibited repetition effects in multiple cortical regions, a subset of which was modulated by successful encoding. Subsequent memory of novelty was associated only with activation differences in a distinct set of regions, including the hippocampus and medial cortical regions. These results suggest that conceptual novelty (a) does not (easily) trigger the repetition suppression phenomenon but requires sustained neural recruitment and (b) activates dedicated encoding mechanisms. Conceptual familiarity, in contrast, allows rapid neural processing that depends upon existing neural representations. Overall, these findings challenge the definition of novelty as a unitary concept. Furthermore, they bear important implications for research into the neural bases of knowledge representation and recognition memory.

Motivation and prediction-driven processing of social memoranda.

Social semantic memory guides many aspects of behavior. Individuals rely on acquired and inferred knowledge about personal characteristics and group membership to predict the behavior and character of social targets. These predictions then determine the expectations from, the behavior in, and the interpretations of social interactions. According to predictive processing accounts, mnemonic and attentional mechanisms should enhance the processing of prediction-violating events. However, empirical findings suggest that prediction-consistent social events are often better remembered. This mini-review integrates recent evidence from social and non-social memory research to highlight the role of motivation in explaining these discrepancies. A particular emphasis is given to the continuous nature of prediction-(in)consistency, the epistemic tendency of perceivers to maintain or update their knowledge, and the dynamic influences of motivation on multiple steps in prediction-driven social memory. The suggested framework provides a coherent outlook of existing work and offers promising future directions to better understand the ebb and flow of social memoranda.

Is it better to be happy or right? Examining the relative role of the pragmatic and epistemic imperatives in momentary affective evaluations.

According to research highlighting the importance of predictions, the confirmation of expectations may be a positively-laden experience. A strong test of this principle is the case of the "doomsayer's delight": the possibility that belief confirmation can be rewarding even when negative expectations are realized. In order to investigate this idea, we conducted two high-powered experiments examining people's immediate affective reactions following exposure to expected or unexpected positive and negative stimuli. The results show that people feel significantly worse when their pessimistic expectations are confirmed than when their optimistic expectations are violated. This finding was not moderated by several theoretically relevant individual difference measures or temporal dynamics. Findings from this study contribute to our understanding of the interplay between epistemic and pragmatic motivations in guiding emotional responses. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Lack of source memory as a potential marker of early assimilation of novel items into current knowledge.

In daily life, humans process a plethora of new information that can be either consistent (familiar) or inconsistent (novel) with prior knowledge. Over time, both types of information can integrate into our accumulated knowledge base via distinct pathways. However, the mnemonic processes supporting the integration of information that is inconsistent with prior knowledge remain under-characterized. In the current study, we used functional magnetic resonance imaging (fMRI) to examine the initial assimilation of novel items into the semantic network. Participants saw three repetitions of adjective-noun word pairs that were either consistent or inconsistent with prior knowledge. Twenty-four hours later, they were presented with the same stimuli again while undergoing fMRI scans. Outside the scanner, participants completed a surprise recognition test. We found that when the episodic context associated with initially inconsistent items was irretrievable, the neural signature of these items was indistinguishable from that of consistent items. In contrast, initially inconsistent items with accessible episodic contexts showed neural signatures that differed from those associated with consistent items. We suggest that, at least one day post encoding, items inconsistent with prior knowledge can show early assimilation into the semantic network only when their episodic contexts become inaccessible during retrieval, thus evoking a sense of familiarity.

The Psychological Science Accelerator's COVID-19 rapid-response dataset.

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data.

Does this ring a bell? Music-cued retrieval of semantic knowledge and metamemory judgments.

Failed knowledge recall attempts are sometimes accompanied by a strong feeling of imminent success, giving rise to a "tip-of-the-tongue" (TOT) experience. Similar to successful retrieval (i.e., the Know state, K), a TOT commences with strong cue familiarity but involves only partial retrieval of related information. We sought to characterize the cognitive processes and temporal dynamics of these retrieval states and to extend the applicability of previous findings about TOT to the auditory modality. Participants heard 3-sec initial segments of popular songs and were asked to recall their names. EEG was recorded while participants indicated their retrieval state via button press. Stimulus-locked analyses revealed a significant early left fronto-central difference between TOT and K, at 300-550 msec postcue onset. Post hoc analysis revealed that, in this time window, TOT also differed from DK (Don't Know) responses, which themselves were similar to the K responses. This finding indicates that neural processes, which may reflect strategy selection, ease of semantic processing, familiarity-related processes, or conflict monitoring, are indicative of the fate of our knowledge judgments long before we actually execute them.

The Role of Predictions, Their Confirmation, and Reward in Maintaining the Self-Concept.

The predictive processing framework posits that people continuously use predictive principles when interacting with, learning from, and interpreting their surroundings. Here, we suggest that the same framework may help explain how people process self-relevant knowledge and maintain a stable and positive self-concept. Specifically, we recast two prominent self-relevant motivations, self-verification and self-enhancement, in predictive processing (PP) terms. We suggest that these self-relevant motivations interact with the self-concept (i.e., priors) to create strong predictions. These predictions, in turn, influence how people interpret information about themselves. In particular, we argue that these strong self-relevant predictions dictate how prediction error, the deviation from the original prediction, is processed. In contrast to many implementations of the PP framework, we suggest that predictions and priors emanating from stable constructs (such as the self-concept) cultivate belief-maintaining, rather than belief-updating, dynamics. Based on recent findings, we also postulate that evidence supporting a predicted model of the self (or interpreted as such) triggers subjective reward responses, potentially reinforcing existing beliefs. Characterizing the role of rewards in self-belief maintenance and reframing self-relevant motivations and rewards in predictive processing terms offers novel insights into how the self is maintained in neurotypical adults, as well as in pathological populations, potentially pointing to therapeutic implications.

A multi-lab test of the facial feedback hypothesis by the Many Smiles Collaboration.

Following theories of emotional embodiment, the facial feedback hypothesis suggests that individuals' subjective experiences of emotion are influenced by their facial expressions. However, evidence for this hypothesis has been mixed. We thus formed a global adversarial collaboration and carried out a preregistered, multicentre study designed to specify and test the conditions that should most reliably produce facial feedback effects. Data from n = 3,878 participants spanning 19 countries indicated that a facial mimicry and voluntary facial action task could both amplify and initiate feelings of happiness. However, evidence of facial feedback effects was less conclusive when facial feedback was manipulated unobtrusively via a pen-in-mouth task.

Cooperation between the hippocampus and the striatum during episodic encoding.

The hippocampus and the striatum are thought to play distinct roles in learning and memory, each supporting an independent memory system. A fundamental question is whether, and how, these systems interact to jointly contribute to learning and memory. In particular, it remains unknown whether the striatum contributes selectively to implicit, habitual learning, or whether the striatum may also contribute to long-term episodic memory. Here, we show with functional magnetic resonance imaging (fMRI) that the hippocampus and the striatum interact cooperatively to support episodic memory formation. Participants were scanned during a memory encoding paradigm and, subsequently, were tested for memory of encoded items. fMRI data revealed that successful memory was associated with greater activity in both the hippocampus and the striatum (putamen) during encoding. Furthermore, activity in the hippocampus and the striatum was correlated within subjects for items that were later remembered, but not for items that were forgotten. Finally, across subjects, the strength of the correlation between the hippocampus and the striatum predicted memory success. These findings provide novel evidence for contributions of both the striatum and the hippocampus to successful episodic encoding and for a cooperative interaction between them.

Confirmation of interpersonal expectations is intrinsically rewarding.

People want to interact successfully with other individuals, and they invest significant efforts in attempting to do so. Decades of research have demonstrated that to simplify the dauntingly complex task of interpersonal communication, perceivers predict the responses of individuals in their environment using stereotypes and other sources of prior knowledge. Here, we show that these top-down expectations can also shape the subjective value of expectation-consistent and expectation-violating targets. Specifically, in two neuroimaging experiments (n = 58), we observed increased activation in brain regions associated with reward processing-including the nucleus accumbens-when perceivers observed information consistent with their social expectations. In two additional behavioral experiments (n = 704), we observed that perceivers were willing to forgo money to encounter an expectation-consistent target and avoid an expectation-violating target. Together, these findings suggest that perceivers value having their social expectations confirmed, much like food or monetary rewards.

Examining the transition of novel information toward familiarity.

Throughout their lives, humans encounter multiple instances of new information that can be inconsistent with prior knowledge (novel). Over time, the once-novel information becomes integrated into their established knowledge base, shifting from novelty to familiarity. In this study, we investigated the processes by which the first steps of this transition take place. We hypothesized that the neural representations of initially novel items gradually change over the course of repeated presentations, expressing a shift toward familiarity. We further assumed that this shift could be traced by examining neural patterns using fMRI. In two experiments, while being scanned, participants read noun-adjective word pairs that were either consistent or inconsistent with their prior knowledge. Stimuli were repeated 3-6 times within the scans. Employing mass univariate and multivariate similarity analyses, we showed that the neural representations associated with the initial presentation of familiar versus novel objects differed in lateral frontal and temporal regions, the medial prefrontal cortex, and the medial temporal lobe. Importantly, the neural representations of novel stimuli gradually changed throughout repetitions until they became indistinguishable from their respective familiar items. We interpret these findings as indicating that an early phase of familiarization can be completed within a few repetitions. This initial familiarization can then serve as the prerequisite to the integration of novel items into existing knowledge. Future empirical and theoretical works can build on the current findings to develop a comprehensive model of the transition from novelty to familiarity.

Identifying Resilience Factors of Distress and Paranoia During the COVID-19 Outbreak in Five Countries.

The ongoing COVID-19 pandemic outbreak has affected all countries with more than 100 million confirmed cases and over 2.1 million casualties by the end of January 2021 worldwide. A prolonged pandemic can harm global levels of optimism, regularity, and sense of meaning and belonging, yielding adverse effects on individuals' mental health as represented by worry, paranoia, and distress. Here we studied resilience, a successful adaptation despite risk and adversity, in five countries: Brazil, Colombia, Germany, Israel, and Norway. In April 2020, over 2,500 participants were recruited for an observational study measuring protective and obstructive factors for distress and paranoia. More than 800 of these participants also completed a follow-up study in July. We found that thriving, keeping a regular schedule, engaging in physical exercise and less procrastination served as factors protecting against distress and paranoia. Risk factors were financial worries and a negative mindset, e.g., feeling a lack of control. Longitudinally, we found no increase in distress or paranoia despite an increase in expectation of how long the outbreak and the restrictions will last, suggesting respondents engaged in healthy coping and adapting their lives to the new circumstances. Altogether, our data suggest that humans adapt even to prolonged stressful events. Our data further highlight several protective factors that policymakers should leverage when considering stress-reducing policies.

Moral dilemmas and trust in leaders during a global health crisis.

Trust in leaders is central to citizen compliance with public policies. One potential determinant of trust is how leaders resolve conflicts between utilitarian and non-utilitarian ethical principles in moral dilemmas. Past research suggests that utilitarian responses to dilemmas can both erode and enhance trust in leaders: sacrificing some people to save many others ('instrumental harm') reduces trust, while maximizing the welfare of everyone equally ('impartial beneficence') may increase trust. In a multi-site experiment spanning 22 countries on six continents, participants (N = 23,929) completed self-report (N = 17,591) and behavioural (N = 12,638) measures of trust in leaders who endorsed utilitarian or non-utilitarian principles in dilemmas concerning the COVID-19 pandemic. Across both the self-report and behavioural measures, endorsement of instrumental harm decreased trust, while endorsement of impartial beneficence increased trust. These results show how support for different ethical principles can impact trust in leaders, and inform effective public communication during times of global crisis. PROTOCOL REGISTRATION STATEMENT: The Stage 1 protocol for this Registered Report was accepted in principle on 13 November 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.13247315.v1 .

Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus.

An adaptive memory system rarely learns information tabula rasa, but rather builds on prior knowledge to facilitate learning. How prior knowledge influences the neural representation of novel associations remains unknown. Here, participants associated pairs of faces in two conditions: a famous, highly familiar face with a novel face or two novel faces while undergoing fMRI. We examine multivoxel activity patterns corresponding to individual faces before and after learning. The activity patterns representing members of famous-novel pairs becomes separated in the hippocampus, that is, more distinct from one another through learning, in striking contrast to paired novel faces that become similar. In the left inferior frontal gyrus, however, prior knowledge leads to integration, and in a specific direction: the representation of the novel face becomes similar to that of the famous face after learning, suggesting assimilation of new into old memories. We propose that hippocampal separation might resolve interference between existing and newly learned information, allowing cortical assimilation. Thus, associative learning with versus without prior knowledge relies on radically different computations.

Human Face-Selective Cortex Does Not Distinguish between Members of a Racial Outgroup.

People often fail to individuate members of social outgroups, a phenomenon known as the outgroup homogeneity effect. Here, we used functional magnetic resonance imaging (fMRI) repetition suppression to investigate the neural representation underlying this effect. In a preregistered study, White human perceivers (N = 29) responded to pairs of faces depicting White or Black targets. In each pair, the second face depicted either the same target as the first face, a different target from the same race, or a scrambled face outline. We localized face-selective neural regions via an independent task, and demonstrated that neural activity in the fusiform face area (FFA) distinguished different faces only when targets belonged to the perceivers' racial ingroup (White). By contrast, face-selective cortex did not discriminate between other-race individuals. Moreover, across two studies (total N = 67) perceivers were slower to discriminate between different outgroup members and remembered them to a lesser extent. Together, these results suggest that the outgroup homogeneity effect arises when early-to-mid-level visual processing results in an erroneous overlap of representations of outgroup members.