RESUMO
Twenty-three extracranial carotid artery aneurysms were encountered in 19 patients. Arteriosclerosis was evident in 16 aneurysms. Severe arterial hypertension affected all patients with arteriosclerotic lesions. Trauma, penetrating neck injury once, and blunt neck injury three times caused four aneurysms. Three aneurysms resulted from earlier carotid artery operations. All 19 patients were symptomatic. Neurologic symptoms affected 13 individuals. Local symptoms referable to the aneurysmal mass troubled 15 patients. Twenty-one aneurysms were treated operatively. There was no operative mortality. Aneurysmectomy with arterial reconstruction was performed 16 times. Aneurysmorrhaphy was undertaken on four occasions and carotid ligation once. Two strokes and multiple cranial nerve injury accounted for three operative complications. No neurologic complications occurred during follow-up totaling 360 man-months. These lesions may be successfully treated by a carefully performed, properly selected operation.
Assuntos
Artéria Carótida Externa/cirurgia , Adolescente , Adulto , Idoso , Arteriosclerose/complicações , Lesões das Artérias Carótidas , Feminino , Humanos , Masculino , Métodos , Pessoa de Meia-Idade , Complicações Pós-OperatóriasRESUMO
Seventy-two patients (39 females and 33 males), 9 to 84 years in age, exhibited a total of 94 renal artery macroaneurysms. Solitary aneurysms affected 53 patients, and multiple aneurysms occurred in 19 patients. Arteriosclerotic changes, observed in nearly 30% of aneurysms, were considered secondary rather than primary processes in most instances. Renal artery fibrodysplasia was an associated finding among 27 patients. In 57 hypertensive patients, evidence supportive of renal artery aneurysms contributing to elevated blood pressure was meager. Two patients experienced frank aneurysmal rupture. Covert rupture into renal veins occurred twice. Aneurysmectomy was performed on 31 occasions. Nephrectomy, partial as well as total, was performed 17 times. No operative mortality occurred. Potential for rupture and an association with functionally important renal artery stenoses support surgical intervention in selected patients with renal artery macroaneurysms.
Assuntos
Aneurisma/patologia , Artéria Renal/patologia , Adolescente , Adulto , Idoso , Aneurisma/complicações , Aneurisma/cirurgia , Arteriosclerose/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nefrectomia , Artéria Renal/cirurgia , Obstrução da Artéria Renal/patologia , Ruptura EspontâneaRESUMO
Neutrophils and monocytes from patients with necrobiosis lipoidica (NL) and granuloma annulare (GA) were studied in vitro in order to detect functional abnormality. Phagocytosis of latex particles and zymosan-induced release of beta-glucuronidase were similar in patients and controls. Plasma from these patients did not enhance or inhibit phagocytosis or enzyme release from normal cells. Our studies suggest that peripheral blood leucocyte function in patients with GA and NL is normal, but this does not exclude a functional abnormality in the lesions.
Assuntos
Granuloma/sangue , Monócitos/fisiologia , Necrobiose Lipoídica/sangue , Neutrófilos/fisiologia , Adolescente , Adulto , Idoso , Glucuronidase/metabolismo , Humanos , Pessoa de Meia-Idade , FagocitoseRESUMO
In situ saphenous vein bypass, using the new valve incision techniques, has shown great promise in the early clinical trials to date. This procedure allows disruption of the venous valves without removal of the vein from its bed, thus allowing preservation of the vasa vasorum and maintenance of the endothelial integrity of the veins. This has allowed an overall improvement in the patency rates of the lower extremity bypasses, particularly in the bypasses to the infrapopliteal position. Also, and perhaps most important, it has permitted the use of smaller veins, with a minimum diameter of 2 mm. This greatly increases the number of patients who can benefit from such a vein bypass since reversed vein bypasses previously have required veins to have a minimum diameter of 3.5 to 4 mm. Long-term follow-up of in situ bypasses is not yet available. However, if the encouraging preliminary results of these bypasses are substantiated on long-term follow-up, in situ saphenous vein bypass may well become recognized as the procedure of choice for lower extremity bypass.
Assuntos
Arteriopatias Oclusivas/cirurgia , Perna (Membro)/irrigação sanguínea , Amputação Cirúrgica , Arteriopatias Oclusivas/mortalidade , Derivação Arteriovenosa Cirúrgica , Artéria Femoral/cirurgia , Humanos , Artéria Poplítea/cirurgia , Veia Safena/cirurgiaRESUMO
Preparations of glomerular basement membrane from diabetic and young and aged normal subjects have been isolated and purified and the component carbohydrates and amino acids quantitatively determined. Diabetic membrane preparations, compared with membranes from young normal subjects, show significant increases in total hexoses, mannose, and galactose and decreases in sialic acid and glucose; the component amino acids show increases in hydroxylysine, proline, and glycine and decreases in lysine, histidine, and leucine. Basement membrane preparations from aged normals show changes in component carbohydrates and amino acids similar to, but not as great as, those seen in the diabetics.
Assuntos
Diabetes Mellitus/metabolismo , Glomérulos Renais/metabolismo , Adolescente , Adulto , Idoso , Envelhecimento , Aminoácidos/análise , Membrana Basal/metabolismo , Carboidratos/análise , Pré-Escolar , DNA/análise , Feminino , Hexosaminas/análise , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Doença das Coronárias/metabolismo , Adenosina Trifosfatases/metabolismo , Animais , Circulação Coronária , Doença das Coronárias/enzimologia , Modelos Animais de Doenças , Cães , Eletrocardiografia , Complexo IV da Cadeia de Transporte de Elétrons/metabolismo , Histocitoquímica , Isocitrato Desidrogenase/metabolismo , L-Lactato Desidrogenase/metabolismo , Radioisótopos , Rubídio/metabolismo , Succinato Desidrogenase/metabolismo , Sais de Tetrazólio , Fatores de TempoAssuntos
Álcoois Graxos/uso terapêutico , Fluocinolona Acetonida/uso terapêutico , Propilenoglicóis/uso terapêutico , Dermatopatias/tratamento farmacológico , Betametasona/administração & dosagem , Betametasona/uso terapêutico , Ensaios Clínicos como Assunto , Combinação de Medicamentos , Escherichia coli/efeitos dos fármacos , Escherichia coli/isolamento & purificação , Fluocinolona Acetonida/administração & dosagem , Humanos , Neomicina/administração & dosagem , Neomicina/uso terapêutico , Pomadas , Veículos Farmacêuticos , Dermatopatias/microbiologia , Staphylococcus/efeitos dos fármacos , Staphylococcus/isolamento & purificação , Esteroides Clorados/administração & dosagem , Esteroides Clorados/uso terapêutico , Valeratos/uso terapêuticoAssuntos
Aneurisma/cirurgia , Artéria Renal , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nefrectomia , Artéria Renal/cirurgiaAssuntos
Complicações do Diabetes , Dermatopatias/etiologia , Vesícula/etiologia , Carbúnculo/etiologia , Angiopatias Diabéticas/complicações , Furunculose/etiologia , Gangrena/etiologia , Granuloma/etiologia , Humanos , Insulina/efeitos adversos , Lipodistrofia/induzido quimicamente , Micoses/etiologia , Necrobiose Lipoídica/etiologia , Prurido/etiologia , Dermatopatias/epidemiologia , Úlcera Cutânea/etiologia , Xantomatose/etiologiaRESUMO
Pooled serum from insulin dependent or non-insulin dependent diabetics stimulated the proliferation of endothelial cells in culture. This potentiating effect was observed only during the growth phase, but not when confluency was reached. Both diabetic and control endothelial cells proliferated normally in control serum.
Assuntos
Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 2/sangue , Veias Umbilicais/citologia , Proteínas Sanguíneas/farmacologia , Divisão Celular , Células Cultivadas , Diabetes Mellitus Tipo 1/patologia , Diabetes Mellitus Tipo 2/patologia , Endotélio/citologia , Substâncias de Crescimento/farmacologia , HumanosRESUMO
Chlorpromazine is well recognized as a cause of delayed photosensitive eczema. A patient illustrated typical features of the phenomenon. Urticarial lesions were also elicited on photopatch testing.
Assuntos
Clorpromazina/efeitos adversos , Transtornos de Fotossensibilidade/induzido quimicamente , Urticária/induzido quimicamente , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The application of Ultralanum ointment to adult skin cases has produced levels of hexachlorophane in the plasma comparable with those found in infants who have undergone whole-body washing with hexachlorophane solutions. Clinical evidence of toxicity was not observed, but it is felt that the value of hexachlorophane in topical steroid preparations should be re-appraised, particularly for long-term treatment of large eczematous areas.
Assuntos
Hexaclorofeno/efeitos adversos , Hexaclorofeno/metabolismo , Absorção Cutânea , Administração Tópica , Idoso , Cromatografia Gasosa , Ensaios Clínicos como Assunto , Feminino , Hexaclorofeno/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Pomadas , Fatores de TempoRESUMO
A linear deposition of IgG was seen by immunofluorescence on the glomerular basement membrane of a diabetic kidney. However, when the remaining kidney was subjected to elution with acidic buffer the eluate had no affinity for glomerular basement membrane. The leucocytes from normal and diabetic subjects were also tested for an in vitro cell-mediated response to diabetic and normal basement membrane. No difference was found between the reaction of leucocytes from diabetics and those from normal age- and sex-matched controls.
Assuntos
Autoanticorpos/análise , Membrana Basal/imunologia , Diabetes Mellitus/imunologia , Glomérulos Renais/imunologia , Adulto , Antígenos , Inibição de Migração Celular , Clorpropamida/uso terapêutico , Diabetes Mellitus/tratamento farmacológico , Imunofluorescência , Humanos , Imunidade Celular , Imunoglobulina G/análise , Insulina/uso terapêutico , Leucócitos/imunologia , Masculino , Pessoa de Meia-IdadeRESUMO
In the mixed leukocyte migration test, white cells from Mantoux positive and Mantoux negative individuals and from patients with sarcoidosis responded similarly to tuberculin, there being no significant difference in the migration index of the three groups. The cells from patients with sarcoidosis, however, showed a depressed response to phytohaemagglutinin. Transfer factor prepared from an individual with a very positive Mantoux reaction did not have any significant effect on the migration index when added to the white cells from sarcoid patients either in the presence or absence of tuberculin.