RESUMO
We reviewed the literature concerning primary brain and spinal tumors with first manifestation or acceleration of symptoms during pregnancy or within the first postpartum week and encountered four new cases in our center. The incidence of brain tumors that become symptomatic during pregnancy appears to be decreased compared with that in age-matched women. The relative frequency of the different primary brain tumor types is not changed by pregnancy. The number of meningiomas gradually tends to increase during pregnancy, with gliomas and spinal vascular tumors accumulating in the first and third trimesters, respectively. Postpartum amelioration of symptoms has especially been described for meningiomas and spinal vascular tumors. We conclude that different types of tumors are influenced at different stages of pregnancy. Although progesterone receptors predominate compared with estrogen receptors, no definite causal relationship with progesterone has been established.
Assuntos
Neoplasias Encefálicas/epidemiologia , Complicações Neoplásicas na Gravidez/epidemiologia , Neoplasias da Medula Espinal/epidemiologia , Adulto , Neoplasias Encefálicas/diagnóstico , Feminino , Glioma/epidemiologia , Humanos , Meningioma/epidemiologia , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias da Medula Espinal/diagnósticoRESUMO
A case of concordant oligodendroglioma in monozygotic twins is reported. The twins were also concordant for uterine leiomyoma and one twin partner had fibroadenoma and lipoma of the breast and myelofibrosis. As very few cases of concordant glioma in monozygotic twins have been published and no such cases in dizygotic twins, a genetic influence in the aetiology of glioma can only be suggested.
Assuntos
Neoplasias Encefálicas/genética , Doenças em Gêmeos , Lobo Frontal , Oligodendroglioma/genética , Lobo Parietal , Gêmeos Monozigóticos , Gêmeos , Feminino , Humanos , Leiomioma/genética , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas , Neoplasias Uterinas/genéticaRESUMO
A literature review of pregnancy-related vertebral haemangiomas, pregnancy-related haemangiomas outside the nervous system and its coverings, and pregnancy-related meningiomas was performed. All three conditions tended to occur during the first pregnancy, the second or third trimester, to ameliorate postpartum, and to recur during a subsequent pregnancy. These results suggested a hormonal influence on the clinical expression of haemangiomas and meningiomas. To test whether a hormonal factor is also operative in the (not pregnancy related) symptomatic and asymptomatic counterparts of these conditions we also reviewed the literature concerning the symptomatic and asymptomatic haemangiomas and meningiomas for the following: frequency, sex and age distribution. No arguments were found to suggest that steroid hormones are strong factors in the development of asymptomatic and symptomatic lesions. The pregnancy-related counterparts have to be considered as subsets with their own behaviour.