Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 84
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
4.
N Engl J Med ; 390(5): 471-475, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38197811
5.
N Engl J Med ; 388(9): e25, 2023 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-36856627
6.
N Engl J Med ; 388(7): e16, 2023 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-36791158
7.
Angew Chem Int Ed Engl ; 60(6): 2939-2942, 2021 02 08.
Artigo em Inglês | MEDLINE | ID: mdl-33103334

RESUMO

A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all-cis-fused, containing six contiguous stereocenters, four of which are quaternary. These structural features were efficiently installed by means of a diastereoselective radical cyclization, followed by an intramolecular Pauson-Khand reaction, a diastereoselective α-alkylation, and a diastereoselective 1,4-addition reaction. Enantioselectivity was introduced at an early stage, by an asymmetric palladium catalyzed decarboxylative allylation reaction on gram scale.

9.
N Engl J Med ; 386(17): 1663-1667, 2022 04 28.
Artigo em Inglês | MEDLINE | ID: mdl-35417632
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA