Anti-cyclic citrullinated peptide antibodies in ulcerative colitis, and its relation with disease activity.

BACKGROUND: Ulcerative colitis an inflammatory bowel disease (IBD) and chronically idiopathic immune related that associates with extraintestinal manifestations such as arthritis. Despite of the highly specificity of anticyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in IBD remains unclear. There are only a few studies on the prevalence of anti-CCP antibodies in patients with IBD. This study aimed to assess the prevalence of anti- CCP antibodies in ulcerative colitis and to investigate possible associations with their clinical and laboratory characteristics Methods: In this cross-sectional study, 93 consecutive patients with ulcerative colitis referred to gastroenterology clinics in Razi referral hospital of Rasht, Iran, from September 2010 to September 2011. Rheumatologic examination, demographic data and clinical presentation of patients were recorded on specially prepared data sheets. Blood sample was collected for assessment of anti-CCP and other laboratory tests. Data were analyzed by the Chi square test, Fisher Exact test and student t test, using the SPSS 20 software for Windows, and P value less than 0.05 was considered significant. RESULTS: Of 93 patients, anti-CCP antibodies detected in 10.8% of cases (CI 95%: 4.5-17.1%). There were a significant relation between the prevalence of anti CCP positivity and aphthous ulcers and ocular manifestations whereas other parameters were not significantly related. CONCLUSION: Anti CCP may have a possible role in some ulcerative colitis manifestations but there was no association between the presence of these antibodies and activity or extension of inflammatory colitis. We suggest other studies especially molecular studies to investigate other aspects of these antibodies in IBD patients.

Prevalence of regular exercise among Iranian adults: a study in northern Iran.

BACKGROUND: Regular exercise is an important aspect of physical activity for people living in urban areas. We examined prevalence of regular exercise in leisure times and some related factors in middle aged men and women in northern Iran. METHOD: A cross-sectional survey was undertaken on 1425 women and 676 men in 2 main cities in northern Iran. Information on exercise habits was collected using a self-administrated questionnaire. Regular exercise was defined as any kind of recreational or sport physical activity other than walking performed three or more days per week for at least 20 minutes. Questions on perceived barriers on regular exercise and walking habit were also included in the questionnaire. RESULTS: Findings showed that 11.2% of the participants (9% in women and 12.8% in men P < .05) did exercise regularly. Prevalence of doing regular exercise was inversely related to age in women but not in men. Educated women were more likely to do regular exercise. The most common perceived barrier for regular exercise was time insufficiency. CONCLUSION: Only a small proportion of the study men and women had sustainable regular exercise for 1 year. Regular exercise was more common among young and well educated women than older women and the men.