Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 282
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
1.
J Reprod Infant Psychol ; 41(5): 516-527, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-35306947

RESUMO

OBJECTIVE: This qualitative study aimed to explore how pregnant women and new mothers self-report changes to their mood and memory during pregnancy. BACKGROUND: Researchers have investigated the various changes that women report throughout their pregnancy. Despite this evidence base, there is a notable lack of studies that take a qualitative approach to understanding how pregnant women and women in the postpartum period experience memory and mood changes through their pregnancy. METHOD: The present study involved a qualitative content analysis of women's first-hand accounts. Of the 423 participants who responded, 118 participants provided textual responses to questions about their memory and 288 participants provided textual responses to questions about their mood. Data were collected online via a free-text survey and analysed using both deductive inductive open coding. RESULTS: A qualitative content analysis generated four overall categories: two typologies of self-reported memory changes in pregnancy ('short-term memory lapses' and 'chronic memory fog') and two typologies of self-reported mood changes ('mood instability and constant change' and 'low mood and parenting anxiety'). CONCLUSION: These typologies represent unique profiles of the memory and mood changes that women experience during pregnancy and serve to accompany and expand the quantitative literature, which documents the changes women experience during pregnancy.


Assuntos
Mães , Gestantes , Feminino , Gravidez , Humanos , Período Pós-Parto , Ansiedade , Depressão
2.
Eur J Nucl Med Mol Imaging ; 47(10): 2461-2468, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32090280

RESUMO

PURPOSE: To evaluate the sensitivity and specificity of PET/CT findings in PMR and generate a diagnostic algorithm utilizing a minimum number of musculoskeletal sites. METHODS: Steroid-naïve patients with newly diagnosed PMR (2012 EULAR/ACR classification criteria) were prospectively recruited to undergo whole-body 18F-FDG PET/CT. Each PMR case was age- and sex-matched to four PET/CT controls. Control scan indication, diagnosis and medical history were extracted from the clinical record. Qualitative and semi-quantitative scoring (maximum standardized uptake value [SUVmax]) of abnormal 18F-FDG uptake at 21 musculoskeletal sites was undertaken for cases and controls. Results informed the development of a novel PET/CT diagnostic algorithm using a classification and regression trees (CART) method. RESULTS: Thirty-three cases met the inclusion criteria and were matched to 132 controls. Mean age was 68.6 ± 7.4 years for cases compared with 68.2 ± 7.3 for controls, and 54.5% were male. Median CRP was 49 mg/L (32-65) and ESR 41.5 mm/h (24.6-64.4) in the PMR group. The predominant control indication for PET/CT was malignancy (63.6%). Individual musculoskeletal sites proved insufficient for diagnostic purposes. A novel algorithm comprising 18F-FDG uptake ≥ 2 adjacent to the ischial tuberosities in combination with either abnormalities at the peri-articular shoulder or interspinous bursa achieved a sensitivity of 90.9% and specificity of 92.4% for diagnosing PMR. CONCLUSIONS: The presence of abnormal 18F-FDG uptake adjacent to the ischial tuberosities together with findings at the peri-articular shoulder or interspinous bursa on whole-body PET/CT is highly sensitive and specific for a diagnosis of PMR. TRIAL REGISTRATION: Clinical Trial Registration: Australian New Zealand Clinical Trials Registry, http://www.anzctr.org.au , ACTRN1261400696695.


Assuntos
Arterite de Células Gigantes , Polimialgia Reumática , Idoso , Austrália , Feminino , Fluordesoxiglucose F18 , Humanos , Masculino , Pessoa de Meia-Idade , Polimialgia Reumática/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons , Sensibilidade e Especificidade
3.
Rheumatology (Oxford) ; 57(2): 345-353, 2018 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-29121248

RESUMO

Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken. MRI of the pelvis, knee and wrist and hand was performed in three representative patients with anatomical correlation of FDG-avid sites carried out using Medview fusion software. Results: Twenty-two patients with PMR were recruited. Their mean age was 68.3 years (s.d. 6.3) and 13/22 were male. On whole-body PET/CT, 18F-FDG uptake adjacent to the ischial tuberosities was observed in 21 participants (95.4%) and recorded the highest mean SUVmax value [3.6 (s.d. 1.7)]. A high frequency of posteromedial knee (61.9%) and wrist and/or hand involvement (66.7%) was also appreciated. MRI of the pelvis revealed high T2 signal surrounding the proximal hamstring tendon origins of both semimembranosus and the conjoint tendon of the semitendinosus and biceps femoris. At the knee, peritendonitis at the distal insertion of the semimembranosus was observed. PET/MRI fusion at the pelvis and knee confirmed semimembranosus peritendonitis as the anatomical correlate of 18F-FDG uptake adjacent to the ischial tuberosities and of posteromedial knee structures. Conclusion: Hamstring peritendonitis is a common and distinctive manifestation of PMR on whole-body PET/CT. Trial registration: Australian New Zealand Clinical Trials Registry, http://www.anzctr.org.au, ACTRN1261400696695.


Assuntos
Fluordesoxiglucose F18 , Imageamento por Ressonância Magnética/métodos , Imagem Multimodal/métodos , Polimialgia Reumática/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Compostos Radiofarmacêuticos , Tendinopatia/diagnóstico por imagem , Idoso , Feminino , Tendões dos Músculos Isquiotibiais/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Polimialgia Reumática/complicações , Estudos Prospectivos , Tendinopatia/etiologia , Imagem Corporal Total/métodos
5.
Med Vet Entomol ; 30(3): 247-52, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27352139

RESUMO

The impact of deltamethrin-impregnated cloth targets on Stegomyia polynesiensis (= Aedes polynesiensis) (Marks) (Diptera: Culicidae) was assessed under laboratory and semi-field settings in French Polynesia. Stegomyia polynesiensis females were released into small laboratory cages and large field cages containing either a deltamethrin-treated or an untreated navy blue cloth, and mosquito knock-down and mortality were assessed. The 24-h mortality rate in mosquitoes exposed to the insecticide-treated target in small cages was 98.0%. These mosquitoes also demonstrated significantly higher levels of knock-down than those exposed to the untreated target. Mortality in field cages was assessed at 24 and 48 h. The 24-h mortality rate in mosquitoes exposed to the control target was 31.2%, whereas that in those exposed to the deltamethrin-treated target was 54.3%. The 48-h mortality rate was also elevated in mosquitoes exposed to the deltamethrin-treated target, but this result did not differ significantly from that observed in mosquitoes exposed to the control target. The significant suppression of female S. polynesiensis by deltamethrin-treated resting targets in this study indicates that these targets could play a role in the control of an important disease vector in the South Pacific region.


Assuntos
Aedes , Controle de Insetos/normas , Inseticidas , Nitrilas , Piretrinas , Animais , Feminino , Polinésia , Análise de Sobrevida
6.
Memory ; 24(4): 496-512, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25782096

RESUMO

Recent research (e.g., Hutter, Crisp, Humphreys, Waters, & Moffit; Siebler) has confirmed that combining novel social categories involves two stages (e.g., Hampton; Hastie, Schroeder, & Weber). Furthermore, it is also evident that following stage 1 (constituent additivity), the second stage in these models involves cognitively effortful complex reasoning. However, while current theory and research has addressed how category conjunctions are initially represented to some degree, it is not clear precisely where we first combine or bind existing social constituent categories. For example, how and where do we compose and temporarily store a coherent representation of an individual who shares membership of "female" and "blacksmith" categories? In this article, we consider how the revised multi-component model of working memory (Baddeley) can assist in resolving the representational limitations in the extant two-stage theoretical models. This is a new approach to understanding how novel conjunctions form new bound "composite" representations.


Assuntos
Memória de Longo Prazo/fisiologia , Memória de Curto Prazo/fisiologia , Humanos , Modelos Psicológicos , Pensamento
7.
J Med Entomol ; 52(3): 375-85, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-26334811

RESUMO

The presence of Aedes albopictus (Skuse) in the Torres Strait of northern Australia increases the potential for colonization and establishment on the mainland. However, there is a possibility that native species that occupy the same habitats may influence the population performance of Ae. albopictus, potentially affecting the establishment of this species in Australia. Cohabitation experiments were performed with the endemic Aedes notoscriptus (Skuse), which has been found occupying the same larval habitats as Ae. albopictus in the Torres Strait and is the most widespread container-inhabiting Aedes species in Australia. The influence of environmental factors and cohabitation between the two species was examined using different climates, food resource levels, food resource types, and species densities. Survivorship proportions and a population performance index (λ') were calculated and compared. The consequences of increased Ae. notoscriptus densities were reduced survivorship and λ' for Ae. albopictus. Despite this, the mean λ' of Ae. albopictus and Ae. notoscriptus was consistently ≥ 1.06, indicating both species could increase under all conditions, potentially due to increasing conspecific densities negatively affecting Ae. notoscriptus. The outcomes from this study suggest that the preexisting presence of Ae. notoscriptus may not prevent the establishment of Ae. albopictus in Australia.


Assuntos
Aedes/fisiologia , Distribuição Animal , Clima , Meio Ambiente , Animais , Comportamento Competitivo , Feminino , Masculino , Densidade Demográfica , Queensland
8.
J Med Entomol ; 51(5): 948-57, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25276922

RESUMO

Aedes albopictus (Skuse) is one of the most invasive mosquito species in the world and has infested islands in the Torres Strait, off the northern coast of Australia since at least 2004. This has led to fears that it may establish on the Australian mainland, including highly populated cities in southern temperate regions. To supplement theoretical projections addressing the range expansion of Ae. albopictus into Australia, laboratory-based trials were conducted to assess the performance of a Torres Strait Ae. albopictus population under a range of Australian conditions. First-instar larvae were placed in individual microcosms and maintained on a natural food resource, under average climatic conditions representing different regions of Australia's east coast. Larvae could not survive winter conditions in southern Australia. As the population performance index was >1.0 for tropical winter and summer conditions, and temperate summer conditions, populations would likely increase during these times. To test whether Ae. albopictus could overwinter during adverse conditions as eggs, we exposed cohorts to four different temperature (7, 17, 27, and 33 degrees C) and relative humidity (35, 55, and 80%) combinations for up to 3 mo. High temperatures and low humidity were most detrimental to egg survival. However, those eggs maintained under cooler climates remained viable after 3 mo, including 17% of eggs kept at 7 degrees C. Overall, this study suggests that a Torres Strait Ae. albopictus strain could proliferate all year round under northern tropical conditions and could overwinter in the egg stage before proliferating in the summer in southern temperate regions.


Assuntos
Aedes/fisiologia , Animais , Austrália , Clima , Demografia
9.
Rheum Dis Clin North Am ; 50(2): 255-267, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38670724

RESUMO

Polymyalgia rheumatica (PMR) immune-related adverse events (ICI-PMRs) represent a novel, distinct entity, despite many clinical, laboratory, and imaging similarities to classical PMR. Important questions remain in differentiating ICI-PMR from classical PMR, as well as other immune-related adverse events and PMR mimics. Despite this, ICI-PMR currently takes treatment cues from classical PMR, albeit with considerations relevant to cancer immunotherapy. Comparisons between ICI-PMR and classical PMR may provide further bidirectional insights, especially given that important questions remain unanswered about both diseases. The cause of classical PMR remains poorly understood, and ICI-PMR may represent a model of induced PMR, with important therapeutic implications.


Assuntos
Inibidores de Checkpoint Imunológico , Polimialgia Reumática , Polimialgia Reumática/induzido quimicamente , Polimialgia Reumática/tratamento farmacológico , Humanos , Inibidores de Checkpoint Imunológico/efeitos adversos
10.
Rheumatol Adv Pract ; 8(1): rkae003, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38375531

RESUMO

The impact of modern imaging in uncovering the underlying pathology of PMR cannot be understated. Long dismissed as an inflammatory syndrome with links to the large vessel vasculitis giant cell arteritis (GCA), a pathognomonic pattern of musculotendinous inflammation is now attributed to PMR and may be used to confirm its diagnosis. Among the available modalities, 18F-fluorodeoxyglucose (18F-FDG) PET/CT is increasingly recognized for its high sensitivity and specificity, as well as added ability to detect concomitant large vessel GCA and exclude other relevant differentials like infection and malignancy. This atlas provides a contemporary depiction of PMR's pathology and outlines how this knowledge translates into a pattern of findings on whole body 18F-FDG PET/CT that can reliably confirm its diagnosis.

11.
Med Vet Entomol ; 27(3): 332-8, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23336712

RESUMO

Aedes polynesiensis Marks (Diptera: Culicidae) is the primary vector of lymphatic filariasis (LF) in the island countries and territories of the South Pacific. In the development of a novel control tool, the response of Ae. polynesiensis to six different colours (three solid fabrics, two patterned fabrics and a plastic tarp) was measured using a digital photographic system. Adult mosquitoes were placed into an environmental chamber and allowed to choose between a white target and one of six experimental targets. Mosquito landing frequency and landing duration were calculated. Adult female Ae. polynesiensis preferred all of the experimental targets to the white control target. Mosquito landing frequency was highest for the solid targets (black, navy blue and red) followed in turn by the two colour pattern targets and the polyethylene target. Mosquito landing duration was greater for experimental targets when compared with white control targets. Mosquito landing frequencies did not change over time during the course of the assay. The response of male Ae. polynesiensis was also measured when exposed to a 100% cotton black target. Male mosquitoes preferred the black target to the white control target, although at levels lower than that observed in female mosquitoes. The results suggest that future investigations evaluating the visual responses of Ae. polynesiensis mosquitoes are warranted, with a special emphasis on semi-field and field-based experiments.


Assuntos
Aedes/fisiologia , Voo Animal , Insetos Vetores/fisiologia , Controle de Mosquitos/métodos , Animais , Cor , Feminino , Masculino , Estimulação Luminosa , Fotografação , Caracteres Sexuais , Percepção Visual
12.
Br J Soc Psychol ; 62(2): 692-707, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36250955

RESUMO

The Stereotype Content Model proposes that social stereotypes broadly exist along two dimensions: warmth and competence. This framework has been used to investigate the contents of stereotypes of gendered groups in a range of contexts. However, it has not been extensively applied to perceptions of pregnant women. This is important, given how pregnant women are typically framed by society to have 'baby brain' or reduced competence. Therefore, we investigated the contents of social stereotypes of pregnant women. In Study 1, participants (N = 590) rated a target group (pregnant women) and thirteen other comparison groups on perceptions of warmth (compassion, empathy and comfort) and competence (mathematics ability, logic and memory). Pregnant women were generally stereotyped to have low competence and high warmth, relative to other groups. Study 2 (N = 54) then descriptively investigated the wider contents of stereotypes related to pregnant women, new mothers, men and women using a trait generation task. Generated traits were coded within the dimensions of warmth and competence. This showed, again, that pregnant women were assigned traits related to warmth and poor competence. Taken together, these studies confirmed that perceptions of low competence and 'baby brain' in pregnancy is broadly held by a non-pregnant sample.


Assuntos
Gestantes , Percepção Social , Gravidez , Masculino , Humanos , Feminino , Estereotipagem , Empatia , Encéfalo
13.
Clin Rheumatol ; 42(12): 3421-3422, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37861872

RESUMO

Despite being the most common inflammatory rheumatic disease in the elderly (Partington et al., Ann Rheum Dis 77(12):1750-175, 2018), few studies to date have examined the patient experience of polymyalgia rheumatica (PMR). Our study explored patient perspectives in PMR by means of a survey and semi-structured group interviews. The results from this study highlight key aspects of the patient experience in PMR, including delays to diagnosis, complex attitudes toward glucocorticoid therapy, and a desire for alternate treatment strategies. Future trials should look to include physical function as a measured outcome. Finally, our results call attention to the chronicity of PMR symptoms, challenging the paradigm of PMR as a self-limiting condition.


Assuntos
Arterite de Células Gigantes , Polimialgia Reumática , Humanos , Idoso , Polimialgia Reumática/diagnóstico , Polimialgia Reumática/tratamento farmacológico , Arterite de Células Gigantes/diagnóstico , Avaliação de Resultados da Assistência ao Paciente , Glucocorticoides/uso terapêutico
14.
Rheumatol Adv Pract ; 7(Suppl 1): i12-i18, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36968633

RESUMO

Objective: Diagnosing septic arthritis can be challenging and frequently involves clinical assessment, laboratory investigations and synovial fluid analysis. We sought to determine the utility of synovial aspiration and intra-operative synovial fluid and tissue culture for the accurate diagnosis of septic arthritis. Methods: We carried out a retrospective review of the records of patients referred to a tertiary orthopaedic unit with possible septic arthritis between 2015 and 2019 inclusive, including clinical and laboratory data for this cohort study. Performance characteristics were determined for synovial aspiration, intra-operative synovial fluid and tissue culture in diagnosing expert review-determined true septic arthritis. Concordance between discharge diagnosis, antibiotic prescribing and true septic arthritis was determined. Results: Of 268 patients identified with suspected septic arthritis, 143 underwent both synovial fluid aspiration and intra-operative synovial fluid and tissue biopsy culture. True septic arthritis was not differentiated significantly by laboratory parameters including serum white cell count (WCC), CRP or synovial WCC. Considering only patients with negative pre-operative synovial aspirate cultures, intra-operative samples led to diagnosis of true septic arthritis in 6 of 63 patients [number needed to treat (NNT) 10.5]. For all patients sampled in theatre, positive synovial tissue biopsy was the only evidence of true septic arthritis in six (NNT 23.9). Despite insufficient microbiological evidence, 27 of the 59 patients who did not have septic arthritis received a discharge diagnosis of septic arthritis, 26 of whom were discharged with antibiotics. Conclusion: Intra-operative sample collection, particularly tissue biopsy, increases the likelihood of a true septic arthritis diagnosis. Such measures might help to reduce diagnostic ambiguity in clinical practice and might therefore reduce overtreatment.

15.
Semin Arthritis Rheum ; 55: 152017, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35537222

RESUMO

OBJECTIVES: To determine the prevalence and predictors of subclinical giant cell arteritis (GCA) in patients with newly diagnosed polymyalgia rheumatica (PMR). METHODS: PubMed, Embase, and Web of Science Core Collection were systematically searched (date of last search July 14, 2021) for any published information on any consecutively recruited cohort reporting the prevalence of GCA in steroid-naïve patients with PMR without cranial or ischemic symptoms. We combined prevalences across populations in a random-effect meta-analysis. Potential predictors of subclinical GCA were identified by mixed-effect logistic regression using individual patient data (IPD) from cohorts screened with PET/(CT). RESULTS: We included 13 cohorts with 566 patients from studies published between 1965 to 2020. Subclinical GCA was diagnosed by temporal artery biopsy in three studies, ultrasound in three studies, and PET/(CT) in seven studies. The pooled prevalence of subclinical GCA across all studies was 23% (95% CI 14%-36%, I2=84%) for any screening method and 29% in the studies using PET/(CT) (95% CI 13%-53%, I2=85%) (n=266 patients). For seven cohorts we obtained IPD for 243 patients screened with PET/(CT). Inflammatory back pain (OR 2.73, 1.32-5.64), absence of lower limb pain (OR 2.35, 1.05-5.26), female sex (OR 2.31, 1.17-4.58), temperature >37° (OR 1.83, 0.90-3.71), weight loss (OR 1.83, 0.96-3.51), thrombocyte count (OR 1.51, 1.05-2.18), and haemoglobin level (OR 0.80, 0.64-1.00) were most strongly associated with subclinical GCA in the univariable analysis but not C-reactive protein (OR 1.00, 1.00-1.01) or erythrocyte sedimentation rate (OR 1.01, 1.00-1.02). A prediction model calculated from these variables had an area under the curve of 0.66 (95% CI 0.55-0.75). CONCLUSION: More than a quarter of patients with PMR may have subclinical GCA. The prediction model from the most extensive IPD set has only modest diagnostic accuracy. Hence, a paradigm shift in the assessment of PMR patients in favour of implementing imaging studies should be discussed.


Assuntos
Arterite de Células Gigantes , Polimialgia Reumática , Biópsia , Feminino , Arterite de Células Gigantes/complicações , Arterite de Células Gigantes/diagnóstico por imagem , Arterite de Células Gigantes/epidemiologia , Humanos , Polimialgia Reumática/complicações , Polimialgia Reumática/diagnóstico por imagem , Polimialgia Reumática/epidemiologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Prevalência
16.
Int J Rheum Dis ; 24(1): 56-62, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33043616

RESUMO

AIM: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) correlate with disease activity in several rheumatic diseases; however, their utility in polymyalgia rheumatica (PMR) remains unclear. This study evaluated their relationship with disease activity and glucocorticoid resistance in PMR. METHOD: Data for disease activity (PMR-AS) and full blood examination was obtained from a prospective observational cohort comprising newly diagnosed, steroid-naïve PMR patients treated with low-dose glucocorticoid therapy. Glucocorticoid resistance was defined as non-response to prednisolone 15 mg/d or initial response followed by flare (PMR-AS ≥ 9.35 or ∆ ≥6.6) upon weaning to 5 mg/d. Univariable Bayesian linear regression analysis of the relationship between PMR-AS (baseline and mean) and NLR and PLR was performed. Predictors of glucocorticoid resistance were identified using a multivariable outcome model, with variables derived from Bayesian model selection. RESULTS: Of the 32 included patients, 16 (50%) fulfilled the primary outcome measure of glucocorticoid resistance. These participants were older, typically female, and had higher baseline C-reactive protein than their glucocorticoid-responsive counterparts. A statistically significant relationship was identified between PMR-AS and both NLR (odds ratio [OR] 28.1; 95% CI 1.6-54.7) and PLR (OR 40.6; 95% CI 10.1-71.4) at baseline, with PLR also found to correlate with disease activity during follow-up (OR 15.6; 95% CI 2.7-28.2). Baseline NLR proved a statistically significant predictor of glucocorticoid-resistant PMR (OR 14.01; 95% CI 1.49-278.06). CONCLUSION: Baseline NLR can predict glucocorticoid resistance in newly diagnosed PMR patients. Both NLR and PLR may be reliable biomarkers of disease activity in PMR.


Assuntos
Resistência a Medicamentos , Glucocorticoides/uso terapêutico , Linfócitos , Neutrófilos , Polimialgia Reumática/tratamento farmacológico , Prednisolona/uso terapêutico , Idoso , Feminino , Humanos , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Polimialgia Reumática/sangue , Polimialgia Reumática/diagnóstico , Polimialgia Reumática/imunologia , Valor Preditivo dos Testes , Estudo de Prova de Conceito , Estudos Prospectivos , Medição de Risco , Fatores de Risco
17.
J Med Entomol ; 46(6): 1387-91, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19960685

RESUMO

Kunzea ambigua (Smith) Druce (Myrtaceae) is an Australian native plant, commonly known as tick bush. The essential oil of the plant has been proposed as a potential mosquito repellent. Commercial K. ambigua oil was analyzed by gas chromatography-mass spectrometry (GC-MS) and its composition compared with that of oils from two individual K. ambigua plants and citronella oil. K. ambigua oils were studied for their repellency against Aedes aegypti L. Formulations of three different K. ambigua essential oils (30% vol:vol) were tested for repellency to mosquitoes using human volunteers. One oil was compared with citronella and N,N'-diethyl-3-methylbenzamide (deet) for repellency. Oil formulations were also tested for repellency with and without the addition of 5% vanillin. The formulation containing commercially produced K. ambigua oil had a mean complete protection time (CPT) of 49 +/- 24 (SD) min. All the K. ambigua formulations had comparable repellency to 40% citronella. However, the 60% citronella formulation showed higher repellency than the 40% K. ambigua formulation. The addition of 5% vanillin did not increase the repellency of K. ambigua oil. Both K. ambigua oil and citronella were significantly less repellent than deet. The K. ambigua essential oil formulations should not be advocated for use as repellents in regions prone to mosquito-borne disease.


Assuntos
Aedes/efeitos dos fármacos , Repelentes de Insetos/farmacologia , Kunzea/química , Óleos Voláteis/farmacologia , Extratos Vegetais/farmacologia , Compostos Orgânicos Voláteis/farmacologia , Animais , Austrália , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Repelentes de Insetos/química , Repelentes de Insetos/isolamento & purificação , Óleos Voláteis/química , Óleos Voláteis/isolamento & purificação , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Compostos Orgânicos Voláteis/isolamento & purificação
18.
Med Vet Entomol ; 23(4): 295-302, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19941595

RESUMO

We report on the first field evaluation of the public acceptability and performance of two types of lethal ovitrap (LO) in three separate trials in Cairns, Australia. Health workers were able to set standard lethal ovitraps (SLOs) in 75 and 71% of premise yards in the wet and dry season, respectively, and biodegradable lethal ovitraps (BLOs) in 93% of yards. Public acceptance, measured as retention of traps by residents, was high for both trap types, with <9% of traps missing after 4 weeks. Traps retaining water after 4 weeks were 78 and 34% for the two SLO trials and 58% for the BLOs. The 'failure rate' in the 535 BLOs set in the field for 4 weeks was 47%, of which 19% were lost, 51% had holes from probable insect chewing, 23% were knocked over, 7% had dried by evaporation and 1% were split. There was no significant difference in the failure rate of BLOs set on porous (grass, soil and mulch) versus solid (tiles, concrete, wood and stone) substrates. The SLOs and the BLOs were readily acceptable to ovipositing Aedes aegypti L. (Diptera: Culicidae); the mean number of eggs/trap was 6 and 15, for the dry season and wet season SLO trial, respectively, and 15 for the BLO wet season trial. Indeed, 84-94% of premise yards had egg positive SLOs or BLOs. A high percentage of both wet and dry season SLOs (29 and 70%, respectively) and BLOs (62%) that were dry after 4 weeks were egg positive, indicating the traps had functioned. Lethal strips from SLOs and BLOs that had been exposed for 4 weeks killed 83 and 74%, respectively, of gravid Ae. aegypti in laboratory assays. These results indicate that mass trapping schemes using SLOs and BLOs are not rejected by the public and effectively target gravid Ae. aegypti. The impact of the interventions on mosquito populations is described in a companion paper.


Assuntos
Aedes/virologia , Vírus da Dengue/crescimento & desenvolvimento , Dengue/prevenção & controle , Insetos Vetores/virologia , Controle de Mosquitos/métodos , Animais , Dengue/transmissão , Dengue/virologia , Feminino , Humanos , Controle de Mosquitos/normas , Oviposição , Saúde Pública , Queensland , Estações do Ano
19.
Med Vet Entomol ; 23(4): 303-16, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19941596

RESUMO

In Cairns, Australia, the impacts on Aedes aegypti L. (Diptera: Culicidae) populations of two types of 'lure & kill' (L&K) lethal ovitraps (LOs), the standard lethal ovitrap (SLO) and the biodegradable lethal ovitrap (BLO) were measured during three mass-trapping interventions. To assess the efficacy of the SLO, two interventions (one dry season and one wet season) were conducted in three discrete areas, each lasting 4 weeks, with the following treatments: (i) SLOs (>200 traps, approximately 4/premise), BG-sentinel traps (BGSs; approximately 15, 1/premise) and larval control (container reduction and methoprene treatment) and (ii) larval control alone, and (iii) untreated control. Female Ae. aegypti populations were monitored for 4 weeks pre- and post-treatment in all three areas using BGSs and sticky ovitraps (SOs) or non-lethal regular ovitraps (ROs). In the dry season, 206 SLOs and 15 BGSs set at 54 and 15 houses, respectively, caught and killed an estimated 419 and 73 female Ae. aegypti, respectively. No significant decrease in collection size of female Ae. aegypti could be attributed to the treatments. In the wet season, 243 SLOs and 15 BGSs killed approximately 993 and 119 female Ae. aegypti, respectively. The mean number of female Ae. aegypti collected after 4 weeks with SOs and BGSs was significantly less than the control (LSD post-hoc test). The third mass-trapping intervention was conducted using the BLO during the wet season in Cairns. For this trial, three treatment areas were each provided with BLOs (>500, approximately 4/premise) plus larval control, and an untreated control area was designated. Adult female Ae. aegypti were collected for 4 weeks pre- and post-treatment using 15 BGSs and 20 SOs. During this period, 53.2% of BLOs contained a total of 6654 Ae. aegypti eggs. Over the intervention period, collections of Ae. aegypti in the treatment areas were significantly less than in the control area for BGSs but not SOs. An influx of relatively large numbers of young females may have confounded the measurement of changes in populations of older females in these studies. This is an important issue, with implications for assessing delayed action control measures, such as LOs and parasites/pathogens that aim to change mosquito age structure. Finally, the high public acceptability of SLOs and BLOs, coupled with significant impacts on female Ae. aegypti populations in two of the three interventions reported here, suggest that mass trapping with SLOs and BLOs can be an effective component of a dengue control strategy.


Assuntos
Aedes/virologia , Vírus da Dengue/crescimento & desenvolvimento , Dengue/prevenção & controle , Insetos Vetores/virologia , Controle de Mosquitos/métodos , Animais , Dengue/transmissão , Dengue/virologia , Feminino , Oviposição , Queensland , Estações do Ano
20.
Br J Psychol ; 100(Pt 1): 133-49, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18547460

RESUMO

In two experiments we tested the hypothesis that repeated exposure to out-group-relevant attitude objects would lead to less liking following a threat to identity. In Experiment 1 exposure to abstract artwork ostensibly created by a member of an out-group university led to more liking under baseline conditions, but not following a manipulation of threat. In Experiment 2 we observed a negative relationship between exposure and liking following threat: liking reversed the typical mere exposure effect. Reported emotion mediated the interactive effect of threat and exposure on liking. These findings illustrate how social identity threat can be experienced incrementally as a function of exposure. We discuss the findings in the context of an integration of research on exposure, identity, attitudes, and contact.


Assuntos
Afeto , Atitude , Processos Grupais , Desejabilidade Social , Feminino , Humanos , Projetos Piloto , Identificação Social , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA