Time for lessons from the first wave of SARS-CoV-2 epidemic. A case report of a patient with acute psychosis and COVID-19 and later virus reactivation.

A case of a middle-aged male, suffering from acute psychosis while in self-isolation due to COVID-19 (coronavirus disease 2019) is presented. The patient required urgent hospital admission due to psychosis, which was only possible to COVID-19 unit of the Department of Infectious Diseases at the time. After transfer to psychiatric hospital, stool sample, taken as an additional preventive measure, was positive for the novel coronavirus. In addition, the patient experienced spontaneous virus reactivation few weeks later. This case report describes certain dilemmas, based on care for patients with mental illness as Europe stands on the brink of COVID-19 second wave.

Association of SOD2, GPX1, CAT, and TNF genetic polymorphisms with oxidative stress, neurochemistry, psychopathology, and extrapyramidal symptoms in schizophrenia.

There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluated the polymorphisms of manganese superoxide dismutase SOD2Val16Ala, glutathione peroxidase GPX1Pro200Leu, catalase CAT-262C>T and CATc.66+78C>T, and tumour necrosis factor-alpha TNF-308G>A by assessing their association with biomarkers of oxidative stress, neurochemistry, psychopathology of schizophrenia and extrapyramidal symptoms in Caucasian schizophrenia patients treated with haloperidol depot. TNF-308G>A was associated with the increased risk of parkinsonism. No major role of polymorphism of SOD2Val16Ala, CAT-262C>T nor GPX1Pro200Leu in psychopathology of schizophrenia or extrapyramidal symptoms was observed. SOD2Val16Ala polymorphism was associated with dopamine plasma concentration and blood concentration ratio between reduced and oxidised form of glutathione, while GPX1Pro200Leu was related with concentration of reduced glutathione. CATc.66+78C>T was associated with noradrenaline plasma concentration and PANSS negative score. PANSS positive and general scores, were associated with the increased risk of tardive dyskinesia. PANSS positive, negative, and general scores, and GAF score were all associated with the increased risk of akathisia.