RESUMO
Comparative analysis of PSA values measured by MEIA and ELSA techniques in a group of 70 unselected patients. A good correlation was observed between PSA levels determined by ELSA-PSA immunoradiometric techniques and those obtained by MEIA-PSA (r = 0.93, p < 0.00001). However, ELSA-PSA values have been 1.73 +/- 0.1 times higher than those by MEIA-PSA. A mean-paired comparison indicates that PSA mean levels (0.48 +/- 0.07 and 0.29 +/- 0.05 for ELSA and MEIA, respectively) are significantly different and define two groups of nonhomogeneous values (p < 0.0001). The same results are obtained when patients with PSA values higher and lower than 4 ng/ml are analyzed separately. For patients with PSA lower than 1 ng/ml, the difference between mean ELSA-PSA and MEIA-PSA values disappears; 0.74 +/- 0.08 vs 0.62 +/- 0.05, respectively (p > 0.1). In this group, the results from both assays are statistically consistent. When considering the group of patients with PSA < 1 ng/ml, no difference between both techniques becomes apparent, which seems to indicate the absence of differences in sensitivity between both techniques when considering low levels of serum PSA. Nevertheless, it is clear that the results from these techniques can not overlap and are not comparable and so, to all practical effects, it is recommended that follow-up of any particular patient is made always with the same technique and even at the same laboratory.
Assuntos
Ensaio de Imunoadsorção Enzimática/métodos , Técnicas Imunoenzimáticas , Antígeno Prostático Específico/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Ensaio de Imunoadsorção Enzimática/estatística & dados numéricos , Estudos de Avaliação como Assunto , Humanos , Técnicas Imunoenzimáticas/estatística & dados numéricos , Modelos Lineares , Masculino , Microesferas , Pessoa de Meia-Idade , Estudos Prospectivos , Doenças Prostáticas/diagnóstico , Sensibilidade e EspecificidadeAssuntos
Radioisótopos do Iodo , Compostos Radiofarmacêuticos , Pertecnetato Tc 99m de Sódio , Doenças da Glândula Tireoide/diagnóstico por imagem , Glândula Tireoide/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Radioisótopos do Iodo/administração & dosagem , Cintilografia , Compostos Radiofarmacêuticos/administração & dosagem , Pertecnetato Tc 99m de Sódio/administração & dosagemAssuntos
Ventrículos do Coração/diagnóstico por imagem , Adulto , Arritmias Cardíacas/diagnóstico por imagem , Criança , Eritrócitos , Ventrículos do Coração/fisiopatologia , Humanos , Contração Miocárdica , Cintilografia , Volume Sistólico , Tecnécio/administração & dosagem , Agregado de Albumina Marcado com Tecnécio Tc 99m/administração & dosagemAssuntos
Radioisótopos do Iodo/farmacocinética , Compostos Radiofarmacêuticos/farmacocinética , Glândula Tireoide/metabolismo , Administração Oral , Fatores de Confusão Epidemiológicos , Controle de Formulários e Registros , Humanos , Radioisótopos do Iodo/administração & dosagem , Radioisótopos do Iodo/uso terapêutico , Anamnese , Radiometria/instrumentação , Compostos Radiofarmacêuticos/administração & dosagem , Compostos Radiofarmacêuticos/uso terapêutico , Doenças da Glândula Tireoide/diagnóstico , Doenças da Glândula Tireoide/radioterapia , Testes de Função Tireóidea/métodos , Tireotropina , Tri-Iodotironina/metabolismoAssuntos
Consentimento Livre e Esclarecido , Medicina Nuclear , França , Declaração de Helsinki , História do Século XX , Humanos , Consentimento Livre e Esclarecido/história , Consentimento Livre e Esclarecido/legislação & jurisprudência , Defesa do Paciente/história , Defesa do Paciente/legislação & jurisprudência , Fatores de Risco , Espanha , Estados UnidosRESUMO
BACKGROUND AND AIM: In recent years, smoking has been shown to increase insulin resistance. However, other studies have failed to demonstrate this association after correcting for confounding factors such as age, gender, body mass index (BMI) or waist to hip ratio (WHR). This study was conducted to elucidate the relative contributions of smoking, obesity and body fat distribution on insulin resistance and other cardiovascular risk factors. PATIENTS AND METHODS: Cases and controls matched for age, gender and degree of obesity. Evaluations included anthropometrical and biochemical assessments with body mass index (BMI), waist to hip ratio (WHR), lipid profiles and insulin resistance determined by HOMA (Homeostasis Model Assessment). RESULTS AND CONCLUSION: A total of 126 patients (52 smokers and 74 non-smokers) participated in the study. Of all the patients, 22 (17.5%) were lean, 49 (38.9%) overweight and 55 (43.7%) obese. Multivariate stepwise linear regression showed an association of WHR (beta = 0.414, p < 0.001), BMI (beta = 0.211, p = 0.012), the number of smoked cigarettes per day (beta = 0.200, p = 0.011) and serum triglycerides levels (beta = 0.241, p = 0.007) on insulin resistance (R = 0.628, F = 13.841, p < 0.001). An independent effect of smoking on triglycerides levels was also shown. Therefore, smoking, obesity and body fat distribution are independently associated with insulin resistance and lipid profile.