RESUMO
We evaluated the protective effect of ademetionine, cytoflavin, and dihydroquercetin on activity of serum enzymes in rats treated with high doses of sodium valproate for 28 days. Ademetionine and cytoflavin produced the greatest protective effect, the effect of dihydroquercetin was less pronounced. In rats treated with ademetionine, AST activity decreased as soon as on day 7 and remained at this level until the end of the experiment; ALT, alkaline phosphatase, and γ-glutamyl transferase activities decreased on days 21 and 28 of the study. Cytoflavin produced similar effects, the effect of dihydroquercetin was observed on days 21 and 28 for AST, ALT, alkaline phosphatase and on day 28 for γ-glutamyl transferase. These results substantiate the use of hepatoprotective drugs in case of long-term treatment with anticonvulsants in patients with epilepsy.
Assuntos
Anticonvulsivantes/farmacologia , Eritrócitos/efeitos dos fármacos , Mononucleotídeo de Flavina/farmacologia , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Quercetina/análogos & derivados , S-Adenosilmetionina/farmacologia , Succinatos/farmacologia , Ácido Valproico/farmacologia , Fosfatase Alcalina/metabolismo , Animais , Anticonvulsivantes/efeitos adversos , Combinação de Medicamentos , Epilepsia/tratamento farmacológico , Fígado/efeitos dos fármacos , Masculino , Quercetina/farmacologia , Ratos , Fatores de Tempo , Ácido Valproico/efeitos adversos , gama-Glutamiltransferase/metabolismoRESUMO
It is shown that glycine derivatives decrease considerably activation of lipid peroxidation in stress, reduce the duration of the alarm stage of the stress reaction, and limit the stress damage to the heart. The idea of the organism's glycinergic stress limiting system is suggested.
Assuntos
Cardiomiopatias/prevenção & controle , Glicina/análogos & derivados , Peroxidação de Lipídeos/efeitos dos fármacos , Pirrolidinonas/farmacologia , Estresse Psicológico/prevenção & controle , Animais , Cardiomiopatias/etiologia , Cardiomiopatias/metabolismo , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Jejum/fisiologia , Glicina/farmacologia , Glicina/uso terapêutico , Coração/efeitos dos fármacos , Masculino , Miocárdio/metabolismo , Pirrolidinonas/uso terapêutico , Ratos , Restrição Física , Estresse Psicológico/complicações , Estresse Psicológico/metabolismo , Fatores de TempoRESUMO
The paper gives clinical findings of 5 cases of syringomyelia surgical treatment using neurotransplantation of embryonal spinal marrow nerve tissue into the intramedullary cavity. It also discusses problems of sampling, culture and transplantation of embryonal spinal marrow nerve tissues, as well as the results and prospects of this method application.
Assuntos
Transplante de Tecido Fetal/métodos , Medula Espinal/transplante , Siringomielia/cirurgia , Adulto , Técnicas de Cultura/métodos , Estudos de Avaliação como Assunto , Feminino , Seguimentos , Humanos , Imunoglobulinas/análise , Masculino , Pessoa de Meia-Idade , Medula Espinal/embriologia , Siringomielia/imunologiaRESUMO
The paper provides the authors' experience in using neurosonography in the diagnosis of osteoneural abnormalities of the vertebral canal and craniovertebral passage in 22 patients operated on for syringomyelia and Type 1 Arnold-Chiari malformation. Comparison of computed tomographic and X-ray findings and intraoperative verification indicate that neurosonography is of high informative value and they provide evidence for its use in a diagnostic set of follow-ups of patients operated on.